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  4. SS-RJW100

SS-RJW100 is a enantiomer of RJW100, which is a racemic agonist of nuclear receptor liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1). SS-RJW100 promotes recruitment of coregulator protein fragments in vitro, recruits the transcriptional intermediary factor 2 (Tif2) coactivator to LRH-1. SS-RJW100 diminishes LRH-1 allosteric activation networks, shows poor thermal stability.

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SS-RJW100 Chemical Structure

SS-RJW100 Chemical Structure

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1 mg USD 300 In-stock
5 mg USD 750 In-stock
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Based on 1 publication(s) in Google Scholar

SS-RJW100 Related Antibodies

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Description

SS-RJW100 is a enantiomer of RJW100, which is a racemic agonist of nuclear receptor liver receptor homolog 1 (LRH-1) and steroidogenic factor 1 (SF-1). SS-RJW100 promotes recruitment of coregulator protein fragments in vitro, recruits the transcriptional intermediary factor 2 (Tif2) coactivator to LRH-1. SS-RJW100 diminishes LRH-1 allosteric activation networks, shows poor thermal stability[1][2].

IC50 & Target

Ki: 1.2 μM (LRH-1), 30 μM (SF-1)[1]
In Vitro

Liver receptor homolog-1 (LRH-1) and steroidogenic factor-1 (SF-1) are closely related nuclear hormone receptors (NR) that play key roles as regulators of metabolism, inflammation, and proliferation[1].
SS-RJW100 (1 nM-1 mM; ) binds LRH-1 and SF-1, with binding affinity Ki values of 1.2 μM (LRH-1), 30 μM (SF-1), respectively[1].
SS-RJW100 (30 μM; 24 h) increases LRH-1 transcriptional activity in both wild-type and mutant LRH-1 overexpressed Hela cells, without being affected by mutations[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SS-RJW100 Related Antibodies

RT-PCR[1]

Cell Line: Wild-type (WT) and mutant LRH-1 overexpressed Hela cells (T352V, H390A, A349F)
Concentration: 30 μM
Incubation Time: 24 hours; for pre-treatment
Result: Increased increases LRH-1 transcriptional activity.
Showed activation effect on LRH-1 expressing cells without being affected by T352V LRH-1 mutant or H390A LRH-1 mutant.
Molecular Weight

386.57

Formula

C28H34O
Appearance

Liquid (Density: 1.064±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

O[C@H]1CC[C@]2(C(C3=CC=CC=C3)=C)C(C4=CC=CC=C4)=C(CCCCCC)C[C@]12[H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (258.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5869 mL 12.9343 mL 25.8685 mL
5 mM 0.5174 mL 2.5869 mL 5.1737 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5869 mL 12.9343 mL 25.8685 mL 64.6713 mL
5 mM 0.5174 mL 2.5869 mL 5.1737 mL 12.9343 mL
10 mM 0.2587 mL 1.2934 mL 2.5869 mL 6.4671 mL
15 mM 0.1725 mL 0.8623 mL 1.7246 mL 4.3114 mL
20 mM 0.1293 mL 0.6467 mL 1.2934 mL 3.2336 mL
25 mM 0.1035 mL 0.5174 mL 1.0347 mL 2.5869 mL
30 mM 0.0862 mL 0.4311 mL 0.8623 mL 2.1557 mL
40 mM 0.0647 mL 0.3234 mL 0.6467 mL 1.6168 mL
50 mM 0.0517 mL 0.2587 mL 0.5174 mL 1.2934 mL
60 mM 0.0431 mL 0.2156 mL 0.4311 mL 1.0779 mL
80 mM 0.0323 mL 0.1617 mL 0.3234 mL 0.8084 mL
100 mM 0.0259 mL 0.1293 mL 0.2587 mL 0.6467 mL
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SS-RJW100 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SS-RJW100OthersracemicLRH-1SF-1RJW100enantiomerRR-RJW100metabolic homeostasisdiabetesmetabolisminflammationproliferationInhibitorinhibitorinhibit

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