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Results for "

SK-MEL-28 cell

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

3

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-147855
    ACA-28

    		ERK Apoptosis Cancer
    ACA-28 (compound 2a) is a potent ERK MAPK signaling modulator. ACA-28 selectively inhibits cancer cell growth by inducing apoptosis with ERK hyperactivation ACA-28 inhibits cell growth of melanoma cells (SK-MEL-28) and normal melanocytes (NHEM), with IC50 values of 5.3 and 10.1 μM, respectively .
    ACA-28
  • HY-14454
    TPh A
    2 Publications Verification

    Triphenyl Compound A

    		 Others Cancer
    TPh A (Triphenyl Compound A) is a potent inhibitor of the nuclear protein pirin and binds specifically to pirin with a Ki of 0.6 uM. TPh A disrupts the formation of the bcl3–pirin complex. TPh A can be used as a novel small molecule tool to regulate pirin in cells .
    TPh A
  • HY-B0150
    Nicotinamide
    Maximum Cited Publications
    49 Publications Verification

    Niacinamide; Nicotinic acid amide

    		 Organoid Endogenous Metabolite Sirtuin HBV Cancer
    Nicotinamide is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide also inhibits SIRT1. Nicotinamide increases cellular NAD+, ATP, ROS levels. Nicotinamide inhibits tumor growth and improves survival. Nicotinamide also has anti-HBV activity .
    Nicotinamide
  • HY-N4006
    Isoangustone A

    		Apoptosis Autophagy Inflammation/Immunology Cancer
    Isoangustone A is an anticancer and anti-inflammatory agent. Isoangustone A induces cancer cells apoptosis and autophagic cell death .
    Isoangustone A
  • HY-155315
    Tubulin polymerization-IN-51

    		Others Cancer
    Tubulin polymerization-IN-51(compound 7u) is a tubulin polymerization inhibitor with IC50 value of 2.55 - 17.89μM for SK-Mel-28 cells. Tubulin polymerization-IN-51 can be used for cancer research .
    Tubulin polymerization-IN-51
  • HY-155314
    Tubulin polymerization-IN-50

    		Microtubule/Tubulin Cancer
    Tubulin polymerization-IN-50 (compound 7n) is a inhibitor of tubulin polymerization, with the IC50 of 5.05 μM in SK-Mel-28 cells. Tubulin polymerization-IN-50 induces the cell cycle arrest in the G2/M phase .
    Tubulin polymerization-IN-50
  • HY-162045
    Ru-4T

    		Others Cancer
    Ru-4T is a phototherapy agent. Ru-4T has phototherapeutic efficacy (PI = 114,000) against melanoma cells (SK-MEL-28) under broad-band visible light (400-700 nm) with EC50 values of 740 pM .
    Ru-4T
  • HY-W317408
    (+)-Menthyl acetate

    		Biochemical Assay Reagents Others
    (+)-Menthyl acetate is a compound isolated from natural Cunila angustifolia Benth essential oil. The selectivity of (+)-Menthyl acetate is higher than that of MCF-7 cell line, IC50=34.0 μg?mL -1, and lower than that of SK-Mel-28 cell line, IC50=279.9 μg?mL -1, on A549 cell without fatal .
    (+)-Menthyl acetate
  • HY-B0150A
    Nicotinamide Hydrochloride

    Niacinamide Hydrochloride; Nicotinic acid amide Hydrochloride

    		 Sirtuin Endogenous Metabolite HBV Infection Cancer
    Nicotinamide Hydrochloride is a form of vitamin B3 or niacin. Nicotinamide Hydrochloride inhibits SIRT2 activity (IC50: 2 μM). Nicotinamide Hydrochloride also inhibits SIRT1. Nicotinamide Hydrochloride increases cellular NAD+, ATP, ROS levels. Nicotinamide Hydrochloride inhibits tumor growth and improves survival. Nicotinamide Hydrochloride also has anti-HBV activity .
    Nicotinamide Hydrochloride
  • HY-164400
    SIJ1777

    		MEK ERK Akt Apoptosis Cancer
    SIJ1777 is a GNF-7 (HY-10943) derivative, possesses potent anti-cancer effects on melanoma cells harboring BRAF class I/II/III mutations. SIJ1777 substantially inhibits the activation of MEK, ERK, and AKT. SIJ1777 remarkably induces apoptosis and significantly blocks migration, invasion, and anchorage-independent growth of melanoma cells harboring BRAF class I/II/II mutations .
    SIJ1777

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