2. MAPK/ERK Pathway Stem Cell/Wnt PI3K/Akt/mTOR Apoptosis
  3. MEK ERK Akt Apoptosis
  4. SIJ1777

SIJ1777 is a GNF-7 (HY-10943) derivative, possesses potent anti-cancer effects on melanoma cells harboring BRAF class I/II/III mutations. SIJ1777 substantially inhibits the activation of MEK, ERK, and AKT. SIJ1777 remarkably induces apoptosis and significantly blocks migration, invasion, and anchorage-independent growth of melanoma cells harboring BRAF class I/II/II mutations.

For research use only. We do not sell to patients.

SIJ1777 Chemical Structure

SIJ1777 Chemical Structure

CAS No. : 839707-55-0

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

SIJ1777 Related Antibodies

Top Publications Citing Use of Products

View All MEK Isoform Specific Products:

View All Isoforms
MEK1 MEK2 MEK5 MEK

View All ERK Isoform Specific Products:

View All Isoforms
ERK ERK1 ERK2 ERK5 ERK8

View All Akt Isoform Specific Products:

View All Isoforms
Akt Akt1 Akt2 Akt3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

SIJ1777 is a GNF-7 (HY-10943) derivative, possesses potent anti-cancer effects on melanoma cells harboring BRAF class I/II/III mutations. SIJ1777 substantially inhibits the activation of MEK, ERK, and AKT. SIJ1777 remarkably induces apoptosis and significantly blocks migration, invasion, and anchorage-independent growth of melanoma cells harboring BRAF class I/II/II mutations[1].

In Vitro

SIJ1777 possesses 2 to 14-fold enhanced anti-proliferative activities compared with GNF-7 (HY-10943) against melanoma cells (SK-MEL-2, SK-MEL-28, A375, WM3670, WM3629)[1].
SIJ1777 completely suppressed phospho-MEK, -ERK, and -AKT levels at 1 μM concentration, regardless of BRAF mutation status in melanoma cells[1].
SIJ1777 increases cleaved PARP level in a concentration-dependent manner on melanoma cells (SK-MEL-2, SK-MEL-28, C8161, WM3629)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SIJ1777 Related Antibodies
Molecular Weight

536.51

Formula

C26H23F3N8O2
CAS No.
SMILES

O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=NN(C)C=C4)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

SIJ1777 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIJ1777839707-55-0SIJ 1777SIJ-1777MEKERKAktApoptosisMitogen-activated protein kinase kinaseMAPKKMAP2KExtracellular signal regulated kinasesPKBProtein kinase BC8161melanoma cellsSK-MEL-2SK-MEL-28WM3629BRAF mutationInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
SIJ1777
Cat. No.:
HY-164400
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.