2. MAPK/ERK Pathway Stem Cell/Wnt PI3K/Akt/mTOR Apoptosis
  3. MEK ERK Akt Apoptosis
  4. SIJ1777

SIJ1777 is a GNF-7 (HY-10943) derivative, possesses potent anti-cancer effects on melanoma cells harboring BRAF class I/II/III mutations. SIJ1777 substantially inhibits the activation of MEK, ERK, and AKT. SIJ1777 remarkably induces apoptosis and significantly blocks migration, invasion, and anchorage-independent growth of melanoma cells harboring BRAF class I/II/II mutations.

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SIJ1777 Chemical Structure

SIJ1777 Chemical Structure

CAS No. : 839707-55-0

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SIJ1777 Related Antibodies

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Description

SIJ1777 is a GNF-7 (HY-10943) derivative, possesses potent anti-cancer effects on melanoma cells harboring BRAF class I/II/III mutations. SIJ1777 substantially inhibits the activation of MEK, ERK, and AKT. SIJ1777 remarkably induces apoptosis and significantly blocks migration, invasion, and anchorage-independent growth of melanoma cells harboring BRAF class I/II/II mutations[1].

In Vitro

SIJ1777 possesses 2 to 14-fold enhanced anti-proliferative activities compared with GNF-7 (HY-10943) against melanoma cells (SK-MEL-2, SK-MEL-28, A375, WM3670, WM3629)[1].
SIJ1777 completely suppressed phospho-MEK, -ERK, and -AKT levels at 1 μM concentration, regardless of BRAF mutation status in melanoma cells[1].
SIJ1777 increases cleaved PARP level in a concentration-dependent manner on melanoma cells (SK-MEL-2, SK-MEL-28, C8161, WM3629)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SIJ1777 Related Antibodies
Molecular Weight

536.51

Formula

C26H23F3N8O2
CAS No.
SMILES

O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=NN(C)C=C4)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SIJ1777 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIJ1777839707-55-0SIJ 1777SIJ-1777MEKERKAktApoptosisMitogen-activated protein kinase kinaseMAPKKMAP2KExtracellular signal regulated kinasesPKBProtein kinase BC8161melanoma cellsSK-MEL-2SK-MEL-28WM3629BRAF mutationInhibitorinhibitorinhibit

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