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SRC-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Src (3) Endogenous Metabolite (1) Estrogen Receptor/ERR (1) FXR (1) IGF-1R (1) LXR (1) PPAR (1) PROTACs (1) Raf (1) RET (1) Ribosomal S6 Kinase (RSK) (1) ROR (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (1) Inflammation/Immunology (2) Metabolic Disease (3) Neurological Disease (1)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Targets Recommended: Src SHP2

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-123402

GSK3987 1 Publications Verification	LXR	Metabolic Disease
GSK3987 is a pan LXRα/β agonist with EC₅₀s of 50 nM, 40 nM for LXRα-SRC1 and LXRβ-SRC1, respectively. GSK3987 increases the expression of ABCA1 and SREBP-1c. GSK3987 induces cellular cholesterol efflux and triglyceride accumulation ^[1].

HY-117819

TMP920	ROR	Inflammation/Immunology
TMP920 is a highly potent and selective RORγt antagonist. TMP920 inhibits RORγt binding to the SRC1 peptide with an IC₅₀ of 0.03 μM ^[1].

HY-113960

ERRα antagonist-1	Estrogen Receptor/ERR	Cancer
ERRα antagonist-1 (Compound A) is a selective and high affinity estrogen-related receptor α (ERRα) antagonist. ERRα antagonist-1 inhibits interaction of ERRα with Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) and PGC-1β, the IC₅₀ values are 170 nM and 180 nM, respectively. ERRα antagonist-1 does not inhibit the interaction of either ERRβ or ERRγ with PGC-1α and PGC-1β coactivator, and also does not inhibit interaction of ERα or ERβ with PGC-1α or SRC-1 ^[1].

HY-116028

15-deoxy-Δ12,14-Prostaglandin D2 15-Deoxy-Δ12,14-PGD2	Endogenous Metabolite	Cardiovascular Disease
15-deoxy-Δ12,14-PGD2 is a metabolite of PGD2. It is an agonist of PGD2 receptor 2 (DP2) that binds DP2 (Ki=50 nM for the mouse receptor expressed in HEK293 cell membranes) and induces activation of eosinophils (EC₅₀=8 nM). It also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ) and induces PPARγ-mediated transcription in a reporter assay when used at a concentration of 5 μM.1 15-deoxy-Δ12,14-PGD2 is cytotoxic to L1210 murine leukemia cells (IC₅₀=0.3 μg/mL). It inhibits ADP-induced platelet aggregation (IC₅₀=320 ng/ml) less potently than PGD2.

HY-116699

CP-868388 free base	PPAR	Neurological Disease Metabolic Disease Inflammation/Immunology
CP-868388 free base is a potent, selective and orally active PPARα agonist with a K_i value of 10.8 nM. CP-868388 free base has little or no affinity for PPARβ (K_i of 3.47 μM) and PPARγ. CP-868388 free base has hypolipidemic and anti-inflammatory actions ^[1].

HY-156914

*IGF-1R/SRC-IN-1*	IGF-1R Src	Cancer
IGF-1R/SRC-IN-1 (Compound 3b) is an inhibitor for *IGF-1R* (IC₅₀ is 63 μM) and *SRC* .

HY-P5559

ND1-YL2	PROTACs	Cancer
ND1-YL2 is a PROTAC that selectively degrades *SRC-1* via the N-degron pathway. ND1-YL2 significantly inhibits cancer invasion and migration in vitro and in vivo. ND1-YL2 can be used in cancer research ^[1].

HY-139562

BMS-986318	FXR	Metabolic Disease
BMS-986318 is a potent nonbile acid FXR agonist with EC₅₀s of 53 and 350 nM in the FXR Gal4 and SRC-1 recruitment assays, respectively. BMS-986318 has a suitable ADME profile, and demonstrates efficacy in the mouse bile duct ligation model of liver cholestasis and fibrosis.BMS-986318 can be used for the research of nonalcoholic steatohepatitis ^[1].

HY-18507A

AD57 hydrochloride	RET Src Ribosomal S6 Kinase (RSK) Raf	Cancer
AD57 hydrochloride is an orally active multikinase inhibitor, inhibits RET, BRAF, S6K and *Src* .

HY-P3773

*p60c-src* substrate II**	Src	Cancer
p60c-src substrate II is an efficient pentapeptide substrate for the tyrosine kinase *pp60c-src* .

HY-153833

PDS-0330 KVA-E-23A	Others	Cancer
PDS-0330 is a specific and potent *Claudin-1* inhibitor. PDS-0330 interferes with claudin-1/Src association and inhibits colorectal cancer (CRC) progression and metastasis ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P5464

SRC-1 NR box peptide	Peptides	Others
SRC-1 NR box peptide is a biological active peptide. (This peptide is a 14-amino acid fragment from the steroid receptor cofactor SRC-1 NR II.)

HY-P5458

SRC-1 (686-700)	Peptides	Others
SRC-1 (686-700) is a biological active peptide. (This peptide is amino acids 686 to 700 fragment containing the second LXXLL motif, derived from NR box II of steroid receptor coactivator (SRC1). Coactivator proteins interact with nuclear receptors in a ligand-dependent manner and augment transcription.)

HY-P5559

ND1-YL2	PROTACs	Cancer
ND1-YL2 is a PROTAC that selectively degrades *SRC-1* via the N-degron pathway. ND1-YL2 significantly inhibits cancer invasion and migration in vitro and in vivo. ND1-YL2 can be used in cancer research ^[1].

HY-P3773

*p60c-src* substrate II**	Src	Cancer
p60c-src substrate II is an efficient pentapeptide substrate for the tyrosine kinase *pp60c-src* .

Species:	Human (3) Mouse (1)
Tag:	His (4) GST (2) Flag (1)
Source:	Sf9 insect cells (2) Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P73422

	Src Protein, Human (sf9, His-GST) Proto-oncogene tyrosine-protein kinase SRC; SRC; p60-SRC; SRC1	Human	Sf9 insect cells
	Src is a non-receptor protein tyrosine kinase that centralizes multiple cellular processes triggered by various receptors. It controls gene transcription, immune response, adhesion, cell cycle, apoptosis, migration and transformation. Src Protein, Human (sf9, His-GST) is the recombinant human-derived Src protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of Src Protein, Human (sf9, His-GST) is 536 a.a., with molecular weight of ~81 kDa.

HY-P73423

	Src Protein, Mouse (sf9, His-GST) Proto-oncogene tyrosine-protein kinase SRC; SRC; p60-SRC; SRC1	Mouse	Sf9 insect cells
	Src, a non-receptor protein tyrosine kinase, displays a unique ability to phosphorylate synaptophysin with high affinity.Src Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived Src protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P701321

	SRC Protein, Human (His) Proto-oncogene tyrosine-protein kinase SRC; Proto-oncogene c-SRC; pp60c-SRC (p60-SRC); SRC1	Human	E. coli
	Src is a non-receptor protein tyrosine kinase that centralizes multiple cellular processes triggered by various receptors. It controls gene transcription, immune response, adhesion, cell cycle, apoptosis, migration and transformation. SRC Protein, Human (His) is the recombinant human-derived SRC protein, expressed by E. coli , with N-10*His labeled tag. The total length of SRC Protein, Human (His) is 535 a.a., with molecular weight of 64.2 kDa.

HY-P702724

	Src Protein, Human (sf9, His, Flag) Proto-oncogene tyrosine-protein kinase SRC; SRC; p60-SRC; SRC1	Human	Sf9 insect cells
	Src is a non-receptor protein tyrosine kinase that centralizes multiple cellular processes triggered by various receptors. It controls gene transcription, immune response, adhesion, cell cycle, apoptosis, migration and transformation. Src Protein, Human (sf9, His, Flag) is the recombinant human-derived Src, expressed by Sf9 insect cells , with His, Flag labeled tag. ,

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HY-P80339

	SRC1 Antibody	WB, IHC-P, IP	Human
	SRC1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 157 kDa, targeting to SRC1. It can be used for WB,IHC-P,IP assays with tag free, in the background of Human.

HY-P81990

	KAT13A Antibody (YA1735) bHLHe74; mNRC 1; NCoA 1; RIP160; SRC 1	WB, IHC-P, IP	Human
	KAT13A Antibody (YA1735) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1735), targeting KAT13A, with a predicted molecular weight of 157 kDa (observed band size: 157 kDa). KAT13A Antibody (YA1735) can be used for WB, IHC-P, IP experiment in human background.

HY-P82911

	*Phospho-Src* (Tyr530) Antibody (YA2656)** SRC; SRC1; Proto-oncogene tyrosine-protein kinase SRC; Proto-oncogene c-SRC; pp60c-SRC; p60-SRC	WB, IP	Rat
	Phospho-Src (Tyr530) Antibody (YA2656) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2656), targeting Phospho-Src (Tyr530), with a predicted molecular weight of 60 kDa (observed band size: 60 kDa). Phospho-Src (Tyr530) Antibody (YA2656) can be used for WB, IP experiment in rat background.

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