CP-868388 free base

Name: CP-868388 free base
Brand: MedChemExpress
SKU: HY-116699
Rating: 4.5 (1 reviews)

Cat. No.: HY-116699 Purity: 99.84%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

CP-868388 free base is a potent, selective and orally active PPARα agonist with a K_i value of 10.8 nM. CP-868388 free base has little or no affinity for PPARβ (K_i of 3.47 μM) and PPARγ. CP-868388 free base has hypolipidemic and anti-inflammatory actions.

For research use only. We do not sell to patients.

CP-868388 free base Chemical Structure

CAS No. : 702681-67-2

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 165	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 165	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 490	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 790	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1250	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All PPAR Isoform Specific Products:

View All Isoforms

PPARα PPARβ/δ PPARγ PPAR PPARδ

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

hPPARα

10.8 nM (Ki)

hPPARγ

3.47 μM (Ki)

In Vitro

CP-868388 (0-1 mM) displays robust and dose-dependent recruitment of SRC-1 (EC₅₀ of 4.7 nM) and PGC-1α peptide^[1].
CP-868388 demonstrate robust and selective transcriptional activation of PPARα with an EC₅₀ of 18 nM in HepG2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CP-868388 (0-3 mg/kg; oral gavage; once daily; for 2 days; male B6/CBF1J mice) treatment shows a robust and highly significant decrease in circulating plasma triglycerides. Triglyceride lowering is dose-dependent with the greatest efficacy achieved at the 3.0 mg/kg dose, with triglyceride decreases of ~50%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male B6/CBF1J mice^[1]
Dosage:	0 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration:	Oral gavage; once daily; for 2 days
Result:	Demonstrated a robust and highly significant decrease in circulating plasma triglycerides.

Molecular Weight

439.54

Formula

C₂₆H₃₃NO₅

CAS No.

702681-67-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(N1C[C@H](C2=CC=CC(OC(C)(C(O)=O)C)=C2)CCC1)OCC3=CC=C(C(C)C)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (284.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2751 mL	11.3755 mL	22.7511 mL
5 mM	0.4550 mL	2.2751 mL	4.5502 mL
10 mM	0.2275 mL	1.1376 mL	2.2751 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.84%

Select Batch:

Data Sheet (270 KB) SDS (563 KB)

COA (244 KB) HNMR (241 KB) LCMS (259 KB) OR (170 KB)

Handling Instructions (2659 KB)

References

[1]. Christopher D Kane, et al. Molecular characterization of novel and selective peroxisome proliferator-activated receptor alpha agonists with robust hypolipidemic activity in vivo. Mol Pharmacol. 2009 Feb;75(2):296-306. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2751 mL	11.3755 mL	22.7511 mL	56.8776 mL
	5 mM	0.4550 mL	2.2751 mL	4.5502 mL	11.3755 mL
	10 mM	0.2275 mL	1.1376 mL	2.2751 mL	5.6878 mL
	15 mM	0.1517 mL	0.7584 mL	1.5167 mL	3.7918 mL
	20 mM	0.1138 mL	0.5688 mL	1.1376 mL	2.8439 mL
	25 mM	0.0910 mL	0.4550 mL	0.9100 mL	2.2751 mL
	30 mM	0.0758 mL	0.3792 mL	0.7584 mL	1.8959 mL
	40 mM	0.0569 mL	0.2844 mL	0.5688 mL	1.4219 mL
	50 mM	0.0455 mL	0.2275 mL	0.4550 mL	1.1376 mL
	60 mM	0.0379 mL	0.1896 mL	0.3792 mL	0.9480 mL
	80 mM	0.0284 mL	0.1422 mL	0.2844 mL	0.7110 mL
	100 mM	0.0228 mL	0.1138 mL	0.2275 mL	0.5688 mL