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Isoforms Recommended:	TET1

Results for "

TET1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) DNA Methyltransferase (2) Endogenous Metabolite (1) Oct3/4 (1) Potassium Channel (1) Small Interfering RNA (siRNA) (1) STAT (2) TET Protein (8)
By Research Areas:	Cancer (8) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

NSC-311068	TET Protein	Cancer
NSC-311068 is *TET1* inhibitor. NSC-311068 selectively suppress TET1 transcription and 5-hydroxymethylcytosine (5hmC) modification. NSC-311068 represses the level of TET1 expression and the global 5hmC level. NSC-311068 effectively inhibits cell viability in AML cells with high expression of TET1 ^[1].

Bobcat339 Maximum Cited Publications 16 Publications Verification	DNA Methyltransferase TET Protein	Cancer
Bobcat339 is a potent and selective cytosine-based inhibitor of TET enzyme, with IC₅₀s of 33 μM and 73 μM for *TET1* and *TET2*, respectively. Bobcat339 is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription ^[1].

NSC-370284	STAT TET Protein	Cancer
NSC-370284 is a selective inhibitor of ten-eleven translocation 1 (TET1) and 5-hydroxymethylcytosine (5hmC). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5 ^[1].

5-Hydroxymethylcytosine 5hmC	Endogenous Metabolite	Metabolic Disease Cancer
5-Hydroxymethylcytosine (5hmC) is an oxidized forms of 5-methylcytosine (5mC) in mammalian DNA. 5-Hydroxymethylcytosine is produced from 5mC in an enzymatic pathway involving three 5mC oxidases, Ten-eleven translocation (TET)1, TET2, and TET3. The conversion of 5mC into 5hmC can be the first step in a pathway leading towards DNA demethylation. 5-Hydroxymethylcytosine is associated with gene transcription and frequently used as a mark to investigate dynamic DNA methylation conversion during mammalian development ^[1].

Bobcat339 hydrochloride Maximum Cited Publications 16 Publications Verification	DNA Methyltransferase TET Protein	Cancer
Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC₅₀s of 33 μM and 73 μM for *TET1* and *TET2*, respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription ^[1].

UC-514321	STAT Apoptosis TET Protein	Inflammation/Immunology Cancer
UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses *TET1* expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity ^[1].

OAC1 1 Publications Verification	Oct3/4 TET Protein	Cancer
OAC1 is a potent Oct4 activator. OAC1 activates Oct4 and Nanog promoters and enhances induced pluripotent stem cells (iPSC) formation. OAC1 activates OCT4 through upregulation of HOXB4 expression. OAC1 increases transcription of the Oct4-Nanog-Sox2 triad and *TET1*. OAC1 facilitates the reprogramming of cells by enhancing efficiency and shortening the reprogramming time ^[1] .

TETi76	TET Protein	Cancer
TETi76 is an orally active *TET* family inhibitor with IC₅₀ values ??of 1.5, 9.4 and 8.8 μM for *TET1, TET2* and *TET3, respectively. TETi76 competitively binds to the active site of TET* enzymes, reduces cytosine hydroxymethylation and restricts clonal growth of *TET2* mutants in vitro and in vivo, but does not affect the growth of normal hematopoietic precursor cells. TETi76 can be used for leukemia research ^[1].

TET1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TET1 Human Pre-designed siRNA Set A contains three designed siRNAs for TET1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TET1 Human Pre-designed siRNA Set A TET1 Human Pre-designed siRNA Set A

Succinic acid sodium Wormwood acid sodium	Potassium Channel TET Protein	Neurological Disease
Succinic acid sodium is a potent and orally active anxiolytic agent. Succinic acid sodium shows inhibitory effects on colonic epithelial cell proliferation in vivo. Succinic acid sodium can down-regulate the expression of *KCNMB1* (potassium channel subunit β1) and *TET1* (ten?eleven translocation 1). Succinic acid sodium can be used for gestational hypertension research ^[1] .

(S)-TETS-C4-acid	Others	Inflammation/Immunology
(S)-TETS-C4-acid (Compound 2d) is a hapten coupled directly to a carrier protein through a carboxylic acid functionality. (S)-TETS-C4-acid (Compound 2d) can be used to detect tetramethylenedisulfotetramine (TETS) .

Cat. No.	Compare	Product Name	Species	Source

	TET1 Protein, Human (sf9, FLAG) CXXC6; KIAA1676; LCX	Human	Sf9 insect cells
	TET1 Protein, Human (sf9, FLAG) is the recombinant human-derived TET1, expressed by Sf9 insect cells , with N-Flag labeled tag. ,

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TET1 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
TET1 Human Pre-designed siRNA Set A contains three designed siRNAs for TET1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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