2. Epigenetics
  3. TET Protein
  4. TETi76

TETi76 is an orally active TET family inhibitor with IC50 values ??of 1.5, 9.4 and 8.8 μM for TET1, TET2 and TET3, respectively. TETi76 competitively binds to the active site of TET enzymes, reduces cytosine hydroxymethylation and restricts clonal growth of TET2 mutants in vitro and in vivo, but does not affect the growth of normal hematopoietic precursor cells. TETi76 can be used for leukemia research.

For research use only. We do not sell to patients.

TETi76 Chemical Structure

TETi76 Chemical Structure

CAS No. : 1451750-73-4

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Based on 1 publication(s) in Google Scholar

TETi76 Related Antibodies

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TET1 TET2 TET3

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Description

TETi76 is an orally active TET family inhibitor with IC50 values ??of 1.5, 9.4 and 8.8 μM for TET1, TET2 and TET3, respectively. TETi76 competitively binds to the active site of TET enzymes, reduces cytosine hydroxymethylation and restricts clonal growth of TET2 mutants in vitro and in vivo, but does not affect the growth of normal hematopoietic precursor cells. TETi76 can be used for leukemia research[1].

IC50 & Target[1]

TET1

1.5 μM (IC50)

TET2

9.4 μM (IC50)

TET3

8.8 μM (IC50)

Molecular Weight

216.23

Formula

C10H16O5
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(OCC)C(O)CC(C(OCC)=O)=C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation

Purity: 97.49%

COA (243 KB) HNMR (201 KB) LCMS (146 KB)

Handling Instructions (2659 KB)
References
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TETi76 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TETi761451750-73-4TETi 76TETi-76TET ProteinTET enzymeTen-eleven-translocation (TET) proteinTen-eleven translocation (TET) methylcytosine dioxygenaseCompetitive inhibitionactive sitehydroxymethylationleukemiaInhibitorinhibitorinhibit

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