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Isoforms Recommended:	TRPV

Results for "

TRPV4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (1) Endogenous Metabolite (2) Potassium Channel (1) Small Interfering RNA (siRNA) (1) TRP Channel (27)
By Research Areas:	Cancer (4) Cardiovascular Disease (7) Inflammation/Immunology (9) Metabolic Disease (5) Neurological Disease (8)
Oligonucleotides:	Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Peptides

Natural
Products

Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-114400

TRPV4 agonist-1 free base	TRP Channel	Inflammation/Immunology
TRPV4 agonist-1 free base is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC₅₀ of 60 nM in the hTRPV4 Ca ²⁺ assay .

HY-160603

PF-05214030	TRP Channel	Others
PF-05214030 is a *TRPV4* antagonist (IC₅₀: 4 and 27nM for hTRPV4 and rTRPV4 respectively). PF-05214030 reverses the reduction in bladder capacity caused by intravesical infusion of a TRPV4 agonist .

HY-160900

RN-1665	TRP Channel	Others
RN-1665 is an orally active *TRPV4* antagonist that exhibits excellent selectivity for related TRP receptors such as TRPV1, TRPV3 and TRPM8. RN-1665 is a TRPV4 probe for focus screens, with IC50s of 0.26 μM and 0.39 μM for hTRPV4 and rTRPV4 from human and rat, respectively .

HY-149823

TRPV4 antagonist 4	TRP Channel	Neurological Disease
TRPV4 antagonist 4 is a potent *TRPV4* antagonist with an IC₅₀ value of 22.65 nM. TRPV4 antagonist 4 inhibits TRPV4 current. TRPV4 antagonist 4 shows protective effects on acute lung injury .

HY-114400A

TRPV4 agonist-1	TRP Channel	Inflammation/Immunology
TRPV4 agonist-1 is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay[1].

HY-142620

TRPV4 antagonist 3	TRP Channel	Cardiovascular Disease
TRPV4 antagonist 3 is a *TRPV4* antagonist (pIC₅₀ = 8.4).

HY-RS15124

TRPV4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TRPV4 Human Pre-designed siRNA Set A contains three designed siRNAs for TRPV4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TRPV4 Human Pre-designed siRNA Set A TRPV4 Human Pre-designed siRNA Set A

HY-162765

TRPV4-IN-5	TRP Channel	Inflammation/Immunology
TRPV4-IN-5 (Compound 1f) is a potent *TRPV4* inhibitor (IC₅₀ = 0.46 μM). TRPV4-IN-5 significantly alleviates the symptoms of acute lung injury induced by lipopolysaccharide (HY-D1056) in mice .

HY-W721480

HC-067047 hydrochloride	TRP Channel	Neurological Disease
HC-067047 hydrochloride is a potent and selective *TRPV4* antagonist and reversibly inhibits currents through the human, rat, and mouse *TRPV4* orthologs with IC₅₀ values of 48 nM, 133 nM, and 17 nM, respectively .

HY-110270A

RN-9893 hydrochloride	TRP Channel	Inflammation/Immunology
RN-9893 Hydrochloride is an orally active antagonist of transient receptor potential vanilloid 4 (TRPV4), with IC₅₀ values of 0.42 and 0.66 μM, for humans and rats, respectively .

HY-120691A

GSK205 4 Publications Verification	TRP Channel	Metabolic Disease Inflammation/Immunology
GSK205 is a potent, selective *TRPV4* antagonist with an IC₅₀ of 4.19 μM for inhibiting *TRPV4*-mediated Ca ²⁺ influx .

HY-116291

4α-Phorbol 12,13-didecanoate 4αPDD	TRP Channel	Neurological Disease Inflammation/Immunology
4α-Phorbol 12,13-didecanoate (4αPDD) is a TRPV4 agonist with antidipsogenic effects. 4α-Phorbol 12,13-didecanoate promotes Ca ²⁺ influx .

HY-100208

HC-067047 Maximum Cited Publications 23 Publications Verification	TRP Channel	Cancer
HC-067047 is a potent and selective *TRPV4* antagonist and reversibly inhibits currents through the human, rat, and mouse *TRPV4* orthologs with IC₅₀ values of 48 nM, 133 nM, and 17 nM, respectively .

HY-120514

JNc-440	TRP Channel Potassium Channel	Cardiovascular Disease
JNc-440 is a potent antihypertensive agent. JNc-440 can enhance the interaction of *TRPV4* and Ca ²⁺-activated potassium channel 3 (KCa2.3) in endothelial cells. JNc-440 can also enhance vasodilation, and exerted antihypertensive effects in mice .

HY-100720

GSK2193874 10+ Cited Publications	TRP Channel	Cardiovascular Disease
GSK2193874 is an orally active, potent, and selective *TRPV4* antagonist with IC₅₀s of 2 nM and 40 nM for *rTRPV4* and *hTRPV4* .

HY-112202

GSK3395879	TRP Channel	Cardiovascular Disease
GSK3395879 is a selective and orally bioavailable transient receptor potential vanilloid-4 (TRPV4) antagonist with an IC₅₀ of 1 nM for hTRPV4 .

HY-110270

RN-9893	TRP Channel	Inflammation/Immunology
RN-9893 is a potent and selective TRPV4 receptor antagonist with IC₅₀ values of 320, 420 and 660 nM for mouse, human and rat channels, respectively .

HY-120962

N-Arachidonoyl Taurine	TRP Channel	Metabolic Disease
N-Arachidonoyl Taurine is an activator of the transient receptor potential vanilloid *TRPV1* and *TRPV4, with EC₅₀*s value of 28 μM and 21 μM, respectively .

HY-N2940

Bisandrographolide A BAA	TRP Channel	Inflammation/Immunology
Bisandrographolide A (BAA) activates TRPV4 channel with an EC₅₀ of 790-950 nM. Bisandrographolide A can bind to CD81 and suppress its function. Bisandrographolide A is an anti-inflammatory, immunostimulant, and antihypertensive compound .

HY-19608

GSK1016790A 20+ Cited Publications	TRP Channel Calcium Channel	Cardiovascular Disease Metabolic Disease
GSK1016790A is a potent and selective transient receptor potential vanilloid 4 (TRPV4) channel agonist. GSK1016790A can elicit Ca ²⁺ influx and elevate intracellular Ca ²⁺ in HEK cells .

HY-19975

RN-1734 5+ Cited Publications	TRP Channel	Neurological Disease
RN-1734 is selective antagonist of the TRPV4 channel, completely antagonizes 4αPDD-mediated activation of TRPV4 with comparable, low micromolar IC₅₀s for all three species (hTRPV4: 2.3 μM, mTRPV4: 5.9 μM, rTRPV4: 3.2 μM) . RN-1734 clearly decreases the production of tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β) without altering the number of olig2-positive cells .

HY-19765

GSK2798745 5 Publications Verification	TRP Channel	Cardiovascular Disease
GSK2798745 is a potent, selective, and orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker with IC₅₀s of 1.8 and 1.6 nM for hTRPV4 and rTRPV4, respectively. GSK2798745 can be used in cardiac and respiratory diseases research .

HY-18662

RQ-00203078 3 Publications Verification	TRP Channel	Neurological Disease Cancer
RQ-00203078 is a highly selective, potent and orally active TRPM8 antagonist with IC₅₀s of 5.3 nM and 8.3 nM for rat and human TRPM8 channels, respectively. RQ-00203078 shows little inhibitory action against TRPV1, TRPA1, TRPV4, or TRPM2 channels .

HY-19976

RN-1747 2 Publications Verification	TRP Channel	Cardiovascular Disease
RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 (TRPV4) agonist, with EC₅₀ values are 0.77 μM, 4.0 μM and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively. RN-1747 also antagonizes TRPM8, with an IC₅₀ of 4 μM .

HY-N8264

Moringin 1 Publications Verification	TRP Channel	Neurological Disease Inflammation/Immunology Cancer
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC₅₀ of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities .

HY-101507

Pico145 5+ Cited Publications HC-608	TRP Channel	Cancer
Pico145 (HC-608) is a remarkable inhibitor of *TRPC1/4/5* channels, inhibits (−)-englerin A-activated TRPC4/TRPC5 channels, with IC₅₀s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8 .

HY-157131

TRPV2-selective blocker 1	TRP Channel	Neurological Disease
TRPV2-selective blocker 1 (compound IV2-1) is a selective TRPV2 channel blocker with an IC₅₀ of 6.3 μM. TRPV2-selective blocker 1 does not affect TRPV1, TRPV3 or TRPV4 channels. TRPV2-selective blocker 1 also inhibits TRPV2-mediated Ca ²⁺ influx in macrophages, and inhibits macrophage phagocytosis .

HY-120963

N-Oleoyl Taurine	Endogenous Metabolite	Metabolic Disease
Several different arachidonoyl amino acids, including N-arachidonoyl dopamine and N-arachidonoyl serine, have been isolated and characterized from bovine brain.1 During mass spectral lipidomics analysis of rat brain, a series of fatty acyl amides of a third amino acid, taurine, were discovered.2 This novel class of compounds is present in kidney and activates members of the transient receptor potential (TRP) family of calcium channels.3 N-Oleoyl taurine is an amino-acyl endocannabinoid isolated from rat brain that may activate TRPV1 and TRPV4.

HY-126720

N-Lignoceroyl Taurine	Endogenous Metabolite	Metabolic Disease
N-Lignoceroyl Taurine is an arachidonoyl amino acid and taurine conjugate with a fatty acid that can be isolated from bovine brain. N-Lignoceroyl Taurine is one of several novel taurine-conjugated fatty acids discovered during mass spectrometry lipidomic analysis of the brain and spinal cord of wild-type and fatty acid amide hydrolase (FAAH) knockout mice. N-Lignoceroyl Taurine levels were 23-26-fold higher in FAAH ^-/- mice compared to wild-type mice, suggesting that FAAH utilizes N-Lignoceroyl Taurine as a substrate. However, in vitro experiments with purified FAAH showed that N-Lignoceroyl Taurine was hydrolyzed 2,000-fold slower in FAAH compared to oleoylethanolamide. N-Acyl Taurines with polyunsaturated acyl chains can activate members of the transient receptor potential (TRP) calcium channel family, including TRPV1 and TRPV4.

HY-124001

N-Docosanoyl taurine	TRP Channel	Neurological Disease
N-Docosanoyl taurine is a lipoamino acid. N-Docosanoyl taurine is a discriminatory metabolity that drive the classification of brain regions .

Cat. No.	Product Name	Target	Research Area

HY-P5315

eNOS pT495 decoy peptide	Peptides	Others
eNOS pT495 decoy peptide is a specific decoy peptide to prevent T495 phosphorylation reduced eNOS uncoupling and mitochondrial redistribution. eNOS pT495 decoy peptide is used in ventilator-induced lung injury research .

Moringin 1 Publications Verification	Structural Classification Natural Products Neurological Disease Classification of Application Fields Moringa oleifera Lam. Source classification Moringaceae Plants Inflammation/Immunology Disease Research Fields	TRP Channel
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC₅₀ of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities .

Bisandrographolide A BAA	Structural Classification Andrographis paniculata (Burm. F.) Nees Acanthaceae Terpenoids Source classification Diterpenoids Plants	TRP Channel
Bisandrographolide A (BAA) activates TRPV4 channel with an EC₅₀ of 790-950 nM. Bisandrographolide A can bind to CD81 and suppress its function. Bisandrographolide A is an anti-inflammatory, immunostimulant, and antihypertensive compound .

N-Docosanoyl taurine	Structural Classification Natural Products Source classification Endogenous metabolite	TRP Channel
N-Docosanoyl taurine is a lipoamino acid. N-Docosanoyl taurine is a discriminatory metabolity that drive the classification of brain regions .

Cat. No.	Compare	Product Name	Species	Source

HY-P703350

	TRPV4 Protein, Human (HEK293, His, MBP, Flag) VRL2; VROAC	Human	HEK293
	TRPV4 Protein, Human (HEK293, His, MBP, Flag) is the recombinant human-derived TRPV4, expressed by HEK293 , with His, MBP, Flag labeled tag. ,

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TRPV4 Human Pre-designed siRNA Set A		siRNAs Pre-designed siRNA Sets
TRPV4 Human Pre-designed siRNA Set A contains three designed siRNAs for TRPV4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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