2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. TRPV4-IN-5

TRPV4-IN-5 (Compound 1f) is a potent TRPV4 inhibitor (IC50 = 0.46 μM). TRPV4-IN-5 significantly alleviates the symptoms of acute lung injury induced by lipopolysaccharide (HY-D1056) in mice.

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TRPV4-IN-5 Chemical Structure

TRPV4-IN-5 Chemical Structure

CAS No. : 3046390-54-6

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Description

TRPV4-IN-5 (Compound 1f) is a potent TRPV4 inhibitor (IC50 = 0.46 μM). TRPV4-IN-5 significantly alleviates the symptoms of acute lung injury induced by lipopolysaccharide (HY-D1056) in mice[1].

IC50 & Target

TRPV4

0.46 μM (IC50)

Molecular Weight

490.83

Formula

C20H22Cl3N3O3S
CAS No.
SMILES

O=C(NC1=CC=C(S(=O)(N2CCN(C(C)C)CC2)=O)C=C1)C3=C(Cl)C=C(Cl)C=C3Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TRPV4-IN-5 Related Classifications

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Keywords:

TRPV4-IN-53046390-54-6TRP ChannelTransient receptor potential channelsLipopolysaccharideacute lung injuryInhibitorinhibitorinhibit

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HY-162765
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