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Results for "

WIZ

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-163820
    WIZ degrader 4

    		Others Others
    WIZ degrader 4 (Example 1) is a WIZ degrader with an AC50 value of 160 nM. WIZ degrader 4 can be used to investigate sickle cell disease (SCD) and thalassemia .
    WIZ degrader 4
  • HY-163824
    WIZ degrader 7

    		Others Others
    WIZ degrader 7 (Example 16) is a WIZ degrader with an IC50 value of < 0.01 μM. WIZ degrader 7 can be used to investigate sickle cell disease (SCD) and thalassemia .
    WIZ degrader 7
  • HY-163819
    WIZ degrader 3

    		Others Cardiovascular Disease
    WIZ degrader 3 (Compound 29) is a degrader for widely interspaced zinc finger motifs (WIZ), with an AC50 of 6.4 nM. WIZ degrader 3 induces the expression of fetal hemoglobin (HbF), with an EC50 of 45 nM. WIZ degrader 3 can be used for the research of blood disorders, such as sickle cell disease and β- thalassemia .
    WIZ degrader 3
  • HY-163822
    WIZ degrader 5

    		Others Others
    WIZ degrader 5 (compound 41) is a WIZ degrader and induces the degradation of WIZ with maximum degradation of 88.6% in 293T cells. WIZ degrader 5 can be used for study of sickle cell disease .
    WIZ degrader 5
  • HY-163823
    WIZ degrader 6

    		Others Others
    WIZ degrader 6 (compound 10) is a WIZ degrader with the EC50 of ＜0.01μM. WIZ degrader 6 can be used for study of sickle cell disease .
    WIZ degrader 6
  • HY-162665
    WIZ degrader 1

    		Others Others
    WIZ degrader 1 (Compound 141) is a degrader for widely interspaced zinc finger motifs (WIZ) with an AC50 of 2 nM. WIZ degrader 1 induces the expression of fetal hemoglobin (HbF) with an EC50 of 6 mM. WIZ degrader 1 is used in research of inherited blood disorders .
    WIZ degrader 1
  • HY-163818
    WIZ degrader 2

    		Others Others
    WIZ degrader 2 (Compound 142) is a degrader for widely interspaced zinc finger motifs with an AC50 of 0.011 μM. WIZ degrader 2 induces the expression of fetal hemoglobin (HbF) with an EC50 of 0.038 μM. WIZ degrader 2 can be used in research about inherited blood disorders .
    WIZ degrader 2
  • HY-RS15821
    WIZ Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    WIZ Human Pre-designed siRNA Set A contains three designed siRNAs for WIZ gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    WIZ Human Pre-designed siRNA Set A
    WIZ Human Pre-designed siRNA Set A
  • HY-159098
    dWIZ-1

    		Others Others
    dWIZ-1 is a potent WIZ molecular glue degrader. dWIZ-1 recruitments WIZ(ZF7) to cereblon (CRBN) induces WIZ degradation. dWIZ-1 has the potential for the research of sickle cell disease (SCD) .
    dWIZ-1
  • HY-159099
    HbF inducer 2

    		Molecular Glues Others
    HbF inducer 3 (Compound dWIZ-2) is an orally active molecular glue, which degrades the WIZ transcription factor (DC50=13 nM in primary human erythroid precursor cell) and induces the expression of fetal hemoglobin (HbF) (EC50=100 nM). HbF inducer 3 exhibits good pharmacokinetic characteristics in cynomolgus monkeys .
    HbF inducer 2

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