2. Epigenetics
  3. Histone Methyltransferase
  4. WIZ degrader 1

WIZ degrader 1 (Compound 141) is a degrader for widely interspaced zinc finger motifs (WIZ) with an AC50 of 2 nM. WIZ degrader 1 induces the expression of fetal hemoglobin (HbF) with an EC50 of 6 mM. WIZ degrader 1 is used in research of inherited blood disorders.

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WIZ degrader 1 Chemical Structure

WIZ degrader 1 Chemical Structure

CAS No. : 2839552-68-8

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WIZ degrader 1 Related Antibodies

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EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

WIZ degrader 1 (Compound 141) is a degrader for widely interspaced zinc finger motifs (WIZ) with an AC50 of 2 nM. WIZ degrader 1 induces the expression of fetal hemoglobin (HbF) with an EC50 of 6 mM. WIZ degrader 1 is used in research of inherited blood disorders[1].

Molecular Weight

473.56

Formula

C25H33F2N5O2
CAS No.
SMILES

FC1(F)CCC(CN2CC[C@@H](CC3=CC4=C(N5CCC(NC5=O)=O)C=NN4C=C3)C[C@@H]2C)CC1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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WIZ degrader 1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WIZ degrader 12839552-68-8WIZ degrader1WIZ degrader-1Histone Methyltransferasehemoglobinopathiessickle cell diseasebeta-thalassemiaHEK293TInhibitorinhibitorinhibit

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