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  4. HbF inducer 2

HbF inducer 3 (Compound dWIZ-2) is an orally active molecular glue, which degrades the WIZ transcription factor (DC50=13 nM in primary human erythroid precursor cell) and induces the expression of fetal hemoglobin (HbF) (EC50=100 nM). HbF inducer 3 exhibits good pharmacokinetic characteristics in cynomolgus monkeys.

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HbF inducer 2 Chemical Structure

HbF inducer 2 Chemical Structure

CAS No. : 2654011-51-3

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Description

HbF inducer 3 (Compound dWIZ-2) is an orally active molecular glue, which degrades the WIZ transcription factor (DC50=13 nM in primary human erythroid precursor cell) and induces the expression of fetal hemoglobin (HbF) (EC50=100 nM). HbF inducer 3 exhibits good pharmacokinetic characteristics in cynomolgus monkeys[1].

Molecular Weight

385.46

Formula

C21H27N3O4
CAS No.
SMILES

O=C(C(N(CC1=C2C=CC(OC[C@@H]3N(CC)CCCC3)=C1)C2=O)CC4)NC4=O
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HbF inducer 2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HbF inducer 22654011-51-3HbF inducer2HbF inducer-2Molecular Gluesorally activemacaquesickle cell diseaseSCDcynomolgus monkeyInhibitorinhibitorinhibit

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