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Wrinkles,skin hyperpigmentation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Biochemical Assay Reagents (1) Melanocortin Receptor (2) Tyrosinase (7)
By Research Areas:	Cancer (2) Inflammation/Immunology (2) Metabolic Disease (3) Neurological Disease (1)

11

Inhibitors & Agonists

1

Biochemical Assay Reagents

3

Peptides

1

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

4-Isopropylcatechol 4-IPC	Others	Inflammation/Immunology
4-Isopropylcatechol is a potent and irreversible cutaneous depigmenting agent. 4-Isopropylcatechol significantly inhibits protein biosynthesis in mouse melanoma cells containing high levels of tyrosinase. 4-Isopropylcatechol can be use to study hyperpigmentation of skins .

Tyrosinase-IN-11	Tyrosinase	Metabolic Disease
Tyrosinase-IN-11 is a potent tyrosinase inhibitor with IC₅₀s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research .

α-Arbutin 4-Hydroxyphenyl α-D-glucopyranoside	Tyrosinase	Neurological Disease Metabolic Disease Cancer
α-Arbutin (4-Hydroxyphenyl α-D-glucopyranoside) is a tyrosinase inhibitor, which is used as an effective skin whiteners. α-Arbutin is promising for research of various diseases such as hyperpigmentation disorders, types of cancers, central nervous system disorders, osteoporosis, diabetes .

Tetrapeptide-30	Tyrosinase	Inflammation/Immunology
Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 can act as a tyrosinase inhibitor, lightening hyperpigmentation and evening out skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation .

hTYR/AbTYR-IN-1	Tyrosinase	Cancer
hTYR/AbTYR-IN-1 (Compound 7) is a hTYR/AbTYR dual inhibitor, with IC₅₀s of 5.4 μM and 3.52 μM for hTYR and AbTYR respectively .

4-(1-Phenylethyl)resorcinol	Biochemical Assay Reagents	Others
4-(1-Phenylethyl)resorcinol is a skin lightening agent used in cosmetics. It works by inhibiting the production of melanin, the pigment that gives skin its color. This helps reduce the appearance of dark spots, hyperpigmentation and uneven skin tone. 4-(1-Phenylethyl)resorcinol is considered safe for cosmetic use and is approved for use in several countries.

IIIM-8	Melanocortin Receptor	Others
IIIM-8 is a melanogenesis inhibitor. IIIM-8 inhibits pigment production both in vitro and in vivo without incurring any cytotoxicity in Human Adult Epidermal Melanocytes (HAEM). IIIM-8 can be used for hyperpigmentation disorders research .

Mycosporine 2 glycine	Tyrosinase	Others
Mycosporine 2 glycine is an inhibitor for tyrosinase-related protein 1 (TYRP1), that binds TYRP1 with good affinity and stability. Mycosporine 2 glycine stimulates mild to moderate skin and ocular irritancy. Mycosporine 2 glycine is utilized in sunscreen products to cure hyperpigmentation-related diseases .

Tyrosinase-IN-29	Tyrosinase	Metabolic Disease
Tyrosinase-IN-29 (compound 5c) is a potent inhibitor of tyrosinase abTYR (IC₅₀: 6.11 μM). Tyrosinase-IN-29 can be used to further study the inhibition of skin hyperpigmentation .

Undecylenoyl phenylalanine	Melanocortin Receptor Adrenergic Receptor	Others
Undecylenoyl phenylalanine is an antagonist for α-melanocyte-stimulating hormone (MSH) and β-adrenergic receptor (β-ADR) to reduce the melanogenesis in melanocytes, reduces hyperpigmentation and thus ameliorates melasma lesions and solar lentigines .

Tyrosinase-IN-28	Tyrosinase	Others
Tyrosinase-IN-28 (Compound 4l) is an inhibitor for tyrosinase with IC₅₀ of 72.55 μM, by affecting both substrate binding and enzyme catalysis .

Cat. No.	Product Name	Type

4-(1-Phenylethyl)resorcinol	Thickeners
4-(1-Phenylethyl)resorcinol is a skin lightening agent used in cosmetics. It works by inhibiting the production of melanin, the pigment that gives skin its color. This helps reduce the appearance of dark spots, hyperpigmentation and uneven skin tone. 4-(1-Phenylethyl)resorcinol is considered safe for cosmetic use and is approved for use in several countries.

Cat. No.	Product Name	Target	Research Area

Tetrapeptide-21	Peptides	Others
Tetrapeptide-21 is a bioactive peptide with anti-wrinkle and and reducing skin hyperpigmentation effect, and has been reported used as a cosmetic ingredient .

Tetrapeptide-30	Tyrosinase	Inflammation/Immunology
Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 can act as a tyrosinase inhibitor, lightening hyperpigmentation and evening out skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation .

Manganese tripeptide-1	Peptides	Others
Manganese tripeptide-1 is a bioactive peptide with anti-wrinkle and reducing skin hyperpigmentation effect, and has been reported used as a cosmetic ingredient .

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