2. Metabolic Enzyme/Protease
  3. Tyrosinase
  4. Tyrosinase-IN-11

Tyrosinase-IN-11 is a potent tyrosinase inhibitor with IC50s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research.

For research use only. We do not sell to patients.

Tyrosinase-IN-11 Chemical Structure

Tyrosinase-IN-11 Chemical Structure

CAS No. : 240797-64-2

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10 mg USD 132 In-stock
25 mg USD 225 In-stock
50 mg USD 295 In-stock
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Based on 1 publication(s) in Google Scholar

Tyrosinase-IN-11 Related Antibodies

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Description

Tyrosinase-IN-11 is a potent tyrosinase inhibitor with IC50s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research[1].

In Vitro

Tyrosinase-IN-11 (compound 11c; 0.1-2 μM; 72 小时) decreases the protein levels of both TYR and MiTF in a dose-dependent manner[1].
Tyrosinase-IN-11 (50 μM) is slightly cytotoxic in the human malignant melanoma cells A375 and B16F10 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tyrosinase-IN-11 Related Antibodies

Western Blot Analysis[1]

Cell Line: B16F10 cells
Concentration: 0.1, 0.5, 1, 2 μM
Incubation Time: 72 hours
Result: Decreased the protein levels of both TYR and MiTF in a dose-dependent manner.
In Vivo

Tyrosinase-IN-11 (compound 11c; 0.5, 1 mM; topical administration before UV radiation every day for 2 weeks or after exposure to UV lamp for 5 days/week for two consecutive weeks) exhibits powerful antimelanogenesis ability in a guinea pig model in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female guinea pigs (10 weeks old, 350-500 g) received ultraviolet exposure from a UV lamp[1]
Dosage: 0.5, 1 mM
Administration: Topical administration before UV radiation every day for 2 weeks or after exposure to UV lamp for 5 days/week for two consecutive weeks
Result: Inhibited the production of melanin in a dose-dependent manner.
Molecular Weight

274.27

Formula

C15H14O5
CAS No.
Appearance

Solid

Color

Pink to orange

SMILES

O=C(C1=C(C=C(C=C1)O)O)CCC2=CC=C(C=C2O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (455.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6460 mL 18.2302 mL 36.4604 mL
5 mM 0.7292 mL 3.6460 mL 7.2921 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6460 mL 18.2302 mL 36.4604 mL 91.1511 mL
5 mM 0.7292 mL 3.6460 mL 7.2921 mL 18.2302 mL
10 mM 0.3646 mL 1.8230 mL 3.6460 mL 9.1151 mL
15 mM 0.2431 mL 1.2153 mL 2.4307 mL 6.0767 mL
20 mM 0.1823 mL 0.9115 mL 1.8230 mL 4.5576 mL
25 mM 0.1458 mL 0.7292 mL 1.4584 mL 3.6460 mL
30 mM 0.1215 mL 0.6077 mL 1.2153 mL 3.0384 mL
40 mM 0.0912 mL 0.4558 mL 0.9115 mL 2.2788 mL
50 mM 0.0729 mL 0.3646 mL 0.7292 mL 1.8230 mL
60 mM 0.0608 mL 0.3038 mL 0.6077 mL 1.5192 mL
80 mM 0.0456 mL 0.2279 mL 0.4558 mL 1.1394 mL
100 mM 0.0365 mL 0.1823 mL 0.3646 mL 0.9115 mL
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Tyrosinase-IN-11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tyrosinase-IN-11240797-64-2TyrosinaseL-tyrosinaseL-dopaantioxidantskin hyperpigmentationA375B16F10Inhibitorinhibitorinhibit

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