4-Isopropylcatechol (Synonyms: 4-IPC)

Name: 4-Isopropylcatechol
Brand: MedChemExpress
SKU: HY-139430
Rating: 4.5 (1 reviews)

Cat. No.: HY-139430 Purity: 98.03%: Data Sheet
SDS

COA
Handling Instructions Technical Support

Solubility

In Vivo Dissolution Calculator

4-Isopropylcatechol is a potent and irreversible cutaneous depigmenting agent. 4-Isopropylcatechol significantly inhibits protein biosynthesis in mouse melanoma cells containing high levels of tyrosinase. 4-Isopropylcatechol can be use to study hyperpigmentation of skins.

For research use only. We do not sell to patients.

4-Isopropylcatechol Chemical Structure

CAS No. : 2138-43-4

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 314	In-stock	Estimated Time of Arrival: May 15
Solution
10 mM * 1 mL in DMSO	USD 330	In-stock	Estimated Time of Arrival: May 15
Solid
5 mg	USD 300	In-stock	Estimated Time of Arrival: May 15
10 mg	USD 450	In-stock	Estimated Time of Arrival: May 15
25 mg	USD 750	In-stock	Estimated Time of Arrival: May 15
50 mg	USD 1050	In-stock	Estimated Time of Arrival: May 15
100 mg	USD 1450	In-stock	Estimated Time of Arrival: May 15
200 mg		Get quote
500 mg		Get quote

Get it by May 20 for select sizes. Order within 13 hrs 2 mins.

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Based on 1 publication(s) in Google Scholar

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Description

Molecular Weight

152.19

Formula

C₉H₁₂O₂

CAS No.

2138-43-4

Appearance

Solid

Color

Off-white to light yellow

SMILES

OC1=CC=C(C(C)C)C=C1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (328.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.5706 mL	32.8530 mL	65.7060 mL
5 mM	1.3141 mL	6.5706 mL	13.1412 mL
10 mM	0.6571 mL	3.2853 mL	6.5706 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (8.21 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.25 mg/mL (8.21 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1.25 mg/mL (8.21 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Purity & Documentation

Purity: 98.03%

Select Batch:

Data Sheet (271 KB) SDS (252 KB)

COA (247 KB) HNMR (133 KB) RP-HPLC (271 KB)

Handling Instructions (2659 KB)

References

[1]. Sugano H, et al. Tyrosinase-mediated inhibition of in vitro leucine incorporation into mouse melanoma by 4-isopropylcatechol. Cancer Res. 1975 Nov;35(11 Pt 1):3126-30. [Content Brief]

[2]. Bleehen SS. The treatment of hypermelanosis with 4-isopropylcatechol. Br J Dermatol. 1976 Jun;94(6):687-94. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.5706 mL	32.8530 mL	65.7060 mL	164.2651 mL
	5 mM	1.3141 mL	6.5706 mL	13.1412 mL	32.8530 mL
	10 mM	0.6571 mL	3.2853 mL	6.5706 mL	16.4265 mL
	15 mM	0.4380 mL	2.1902 mL	4.3804 mL	10.9510 mL
	20 mM	0.3285 mL	1.6427 mL	3.2853 mL	8.2133 mL
	25 mM	0.2628 mL	1.3141 mL	2.6282 mL	6.5706 mL
	30 mM	0.2190 mL	1.0951 mL	2.1902 mL	5.4755 mL
	40 mM	0.1643 mL	0.8213 mL	1.6427 mL	4.1066 mL
	50 mM	0.1314 mL	0.6571 mL	1.3141 mL	3.2853 mL
	60 mM	0.1095 mL	0.5476 mL	1.0951 mL	2.7378 mL
	80 mM	0.0821 mL	0.4107 mL	0.8213 mL	2.0533 mL
	100 mM	0.0657 mL	0.3285 mL	0.6571 mL	1.6427 mL

4-Isopropylcatechol Related Classifications

Inflammation/Immunology

Keywords:

4-Isopropylcatechol2138-43-44-IPCTyrosinaseirreversiblemelanomatyrosinasehyperpigmentationskinsInhibitorinhibitorinhibit

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4-Isopropylcatechol (Synonyms: 4-IPC)

Customer Review

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Molarity Calculator

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Complete Stock Solution Preparation Table

4-Isopropylcatechol Related Classifications

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