4-(1-Phenylethyl)resorcinol

Name: 4-(1-Phenylethyl)resorcinol
Brand: MedChemExpress
SKU: HY-125809
Rating: 4.5 (1 reviews)

Cat. No.: HY-125809 Purity: 99.31%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

4-(1-Phenylethyl)resorcinol is a skin lightening agent used in cosmetics. It works by inhibiting the production of melanin, the pigment that gives skin its color. This helps reduce the appearance of dark spots, hyperpigmentation and uneven skin tone. 4-(1-Phenylethyl)resorcinol is considered safe for cosmetic use and is approved for use in several countries.

For research use only. We do not sell to patients.

4-(1-Phenylethyl)resorcinol Chemical Structure

CAS No. : 85-27-8

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
1 g	USD 20	In-stock	Estimated Time of Arrival: December 31
5 g	USD 40	In-stock	Estimated Time of Arrival: December 31
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50 g		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
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Description

In Vitro

Phenylethyl resorcinol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

214.26

Formula

C₁₄H₁₄O₂

CAS No.

85-27-8

Appearance

Solid

Color

Off-white to yellow

SMILES

OC1=CC=C(C(C2=CC=CC=C2)C)C(O)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (466.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6672 mL	23.3361 mL	46.6723 mL
5 mM	0.9334 mL	4.6672 mL	9.3345 mL
10 mM	0.4667 mL	2.3336 mL	4.6672 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (11.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (11.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (11.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.31%

Select Batch:

Data Sheet (245 KB) SDS (392 KB)

COA (247 KB) HNMR (114 KB) RP-HPLC (258 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.6672 mL	23.3361 mL	46.6723 mL	116.6807 mL
	5 mM	0.9334 mL	4.6672 mL	9.3345 mL	23.3361 mL
	10 mM	0.4667 mL	2.3336 mL	4.6672 mL	11.6681 mL
	15 mM	0.3111 mL	1.5557 mL	3.1115 mL	7.7787 mL
	20 mM	0.2334 mL	1.1668 mL	2.3336 mL	5.8340 mL
	25 mM	0.1867 mL	0.9334 mL	1.8669 mL	4.6672 mL
	30 mM	0.1556 mL	0.7779 mL	1.5557 mL	3.8894 mL
	40 mM	0.1167 mL	0.5834 mL	1.1668 mL	2.9170 mL
	50 mM	0.0933 mL	0.4667 mL	0.9334 mL	2.3336 mL
	60 mM	0.0778 mL	0.3889 mL	0.7779 mL	1.9447 mL
	80 mM	0.0583 mL	0.2917 mL	0.5834 mL	1.4585 mL
	100 mM	0.0467 mL	0.2334 mL	0.4667 mL	1.1668 mL