Search Result
Results for "
allergic asthma
" in MedChemExpress (MCE) Product Catalog:
3
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-B1619
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Cromoglicic acid
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Others
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Inflammation/Immunology
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Cromolyn is a mast cell stabilizer. Cromolyn has the potential for the research of bronchial asthma, allergic rhinitis, and certain allergic eye conditions such as vernal conjunctivitis, keratitis, and keratoconjunctivitis .
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- HY-B0462
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- HY-111269
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- HY-N2913
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- HY-148074
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RPT193
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CCR
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Inflammation/Immunology
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Zelnecirnon (RPT193) is an orally active inhibitor of CCR4, blocks the recruitment of Th2 inflammatory immune cells into inflamed tissues. Zelnecirnon can be used for allergic inflammation in atopic dermatitis, asthma, and other diseases research .
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- HY-P4971
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Complement System
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Inflammation/Immunology
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C5a Anaphylatoxin (human) is a pro-inflammatory peptide and a leukocyte chemoattractant. C5a Anaphylatoxin (human) can be used to study inflammation and immunity, such as allergic asthma .
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- HY-B0462A
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- HY-N9977
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Others
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Inflammation/Immunology
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Dihydrocatalpol can be isolated from Rehmannia glutinosa. Dihydrocatalpol can be used for research on Asthma, chronic obstructive pneumonia, allergic rhinitis .
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- HY-B0462R
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Histamine Receptor
SARS-CoV
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Infection
Metabolic Disease
Inflammation/Immunology
Endocrinology
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Azelastine (hydrochloride) (Standard) is the analytical standard of Azelastine (hydrochloride). This product is intended for research and analytical applications. Azelastine hydrochloridem, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine hydrochloride can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2 .
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- HY-105999
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Ser/Thr Protease
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Inflammation/Immunology
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APC 366 is a selective inhibitor of mast cell tryptase (Ki=7.1 μM). APC 366 inhibits antigen-induced early asthmatic response (EAR), late asthmatic response (LAR), and bronchial hyperresponsiveness (BHR) in a sheep model of allergic asthma .
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- HY-103071
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CRAC Channel
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Inflammation/Immunology
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GSK-5503A is a calcium-release activated calcium (CRAC) channel blocker. GSK-5503A effectively inhibits stromal interaction molecule 1 (STIM1) mediated Orai1 and Orai3 currents in vitro. GSK-5503A can be used for the research of asthma and allergic disorders .
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- HY-134772
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STAT
Cytochrome P450
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Inflammation/Immunology
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AS1810722 is an orally active and potent STAT6 inhibitor with an IC50 of 1.9 nM. AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722, a derivative of fused bicyclic pyrimidine, has the potential for allergic diseases such as asthma and atopic diseases research .
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- HY-134771
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AS1617612
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STAT
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Inflammation/Immunology
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YM-341619 (AS1617612) is a potent and orally active STAT6 inhibitor with an IC50 of 0.70 nM. YM-341619 inhibits Th2 differentiation in mouse spleen T cells induced by IL-4 (IC50=0.28 nM) without affecting Th1 cell differentiation . YM-341619 is a promising compound for the the research of allergic diseases, such as allergic asthma .
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- HY-119995
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Apoptosis
Histamine Receptor
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Cardiovascular Disease
Cancer
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Chloropyramine is competitive reversible H1 receptor antagonist. Chloropyramine also has anti-tumour activity in breast cancer. Chloropyramine can be used for the research of allergic conditions, such as conjunctivitis and bronchial asthma .
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- HY-147336
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Drug Metabolite
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Infection
Cardiovascular Disease
Metabolic Disease
Inflammation/Immunology
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Desmethylazelastine is a main active metabolite of Azelastine that is oxidatively metabolized by the cytochrome P450 enzyme system with a protein binding rate of 97% and an elimination half-life of 54 hours. Azelastine is an orally active, selective and high-affinity histamine H1-receptor antagonist. Azelastine can be used in studies of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2 .
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- HY-P1111
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Src
Interleukin Related
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Inflammation/Immunology
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Lyn peptide inhibitor is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor blocks Lyn activation and inhibits the binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors. Lyn peptide inhibitor can be used for study of asthma, allergic, and other eosinophilic disorders .
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- HY-P1111A
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Src
Interleukin Related
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Inflammation/Immunology
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Lyn peptide inhibitor TFA is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor TFA blocks Lyn activation and inhibits the binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors. Lyn peptide inhibitor TFA can be used for study of asthma, allergic, and other eosinophilic disorders .
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- HY-115877
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TRP Channel
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Others
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GDC-0334 is a selective TRPA1 antagonist. GDC-0334 inhibits TRPA1 function on airway smooth muscle and sensory neurons by decreasing cough and allergic airway inflammation in rats and guinea pigs. GDC-0334 can be used for TRPA1-mediated diseases research, such as pain or asthma .
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- HY-106200A
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Lipoxygenase
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Cardiovascular Disease
Inflammation/Immunology
Cancer
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CJ-13,610 (hydrochloride) is an orally active and potent nonredox-type 5-lipoxygenase inhibitor with an IC50 value of 0.07 μM. CJ-13,610 (hydrochloride) competes with activating LOOH at a regulatory LOOH-binding site with high affinity, thereby preventing 5-lipoxygenase catalysis. CJ-13,610 (hydrochloride) is promising for research of diseases related to elevated levels of 5-lipoxygenase such as inflammatory reactions, allergic asthma, various types of cancer and atherosclerosis .
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- HY-U00409
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- HY-P99496
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RPC 4046; ABT 308; CC-93538
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Interleukin Related
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Inflammation/Immunology
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Cendakimab (RPC4046; ABT 308; CC-93538) is a selective, humanized, recombinant monoclonal antibody against the IL-13 molecule. Cendakimab has a high affinity and potency for both human wild-type and variant IL-13 and blocks binding of IL-13 to both IL-13Rα1 and IL-13Rα2 with IC50s of 352 pM and 631 pM by ELISA, respectively. Cendakimab recognizes both wild-type human IL-13 and the common polymorphic variant R110Q, with binding affinities of 52 and 50 pM, respectively. Cendakimab has the potential for IL-13-related allergic/inflammatory diseases (e.g., asthma and eosinophilic esophagitis) .
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- HY-18706
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- HY-14270
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- HY-B1619S
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Cromoglicic acid-d5
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Isotope-Labeled Compounds
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Inflammation/Immunology
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Cromoglicic acid-d5 is the deuterium labeled Cromolyn[1]. Cromolyn is a mast cell stabilizer. Cromolyn has the potential for the research of bronchial asthma, allergic rhinitis, and certain allergic eye conditions such as vernal conjunctivitis, keratitis, and keratoconjunctivitis[2].
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- HY-N7292
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Others
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Inflammation/Immunology
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Bakkenolide B is isolated from petasites japonicas leaves and has anti-allergic and anti-inflammatory effects. Bakkenolide B can be used for the study of asthma .
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- HY-11067
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WHI-P97
2 Publications Verification
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JAK
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Inflammation/Immunology
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WHI-P97 is a potent and selective JAK-3 inhibitor. WHI-P97 is effective in preventing the development allergic asthma in vivo .
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- HY-106358A
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CR 2039; Dizolast
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Phosphodiesterase (PDE)
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Inflammation/Immunology
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Andolast (CR 2039) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC50 value of 50 μM. Andolast can be used for the research of asthma .
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- HY-109544
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MY-5116
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Histamine Receptor
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Inflammation/Immunology
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Repirinast (MY-5116) is an orally active anti-allergic agent. Repirinast inhibits histamine release. Repirinast can be used in the research of bronchial asthma .
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- HY-106358
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CR 2039 free base; Dizolast free base
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Phosphodiesterase (PDE)
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Inflammation/Immunology
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Andolast (CR 2039) (free base) is an anti-allergic agent. Andolast can inhibit cAMP-phosphodiesterase with an IC50 value of 50 μM. Andolast can be used for the research of asthma .
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- HY-113556
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NF-κB
Keap1-Nrf2
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Inflammation/Immunology
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Sappanone A is a homoisoflavanone which exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB. Sappanone can attenuate allergic airway inflammation in Ovalbumin-induced asthma .
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- HY-108243
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- HY-101945
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Lipoxygenase
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Inflammation/Immunology
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A-69412 is a reversible, specific inhibitor of the 5-lipoxygenase (5-LO). A-69412 has the potential to treat asthma and ulcerative colitis, and possibly other inflammatory and allergic conditions.
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- HY-14270R
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Histamine Receptor
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Inflammation/Immunology
Endocrinology
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Lodoxamide (Standard) is the analytical standard of Lodoxamide. This product is intended for research and analytical applications. Lodoxamide (U-42585E free acid) is an antiallergic compound acting as a mast-cell stabilizer for the treatment of asthma and allergic conjunctivitis.
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- HY-N12127
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Others
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Others
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Gymnoside I (compound 1) is a glycosidoxybenzyl 2-isobutylmalic acid. Gymnoside I shows antiallergic activity in passive cutaneous allergic reaction (PCA) in mice. Gymnoside I can be used in research to treat asthma, neurasthenia and chronic hepatitis .
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- HY-13693
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Sch32088
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Glucocorticoid Receptor
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Inflammation/Immunology
Endocrinology
Cancer
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Mometasone furoate (Sch32088) is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic activity. Mometasone furoate acts as a corticosteroid agent and used for topical applications in chronic skin eczema and airway inflammation management of asthma in vivo
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- HY-112549
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5-KETE
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Others
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Cardiovascular Disease
Inflammation/Immunology
Cancer
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5-oxo-ETE is a potent chemoattractant for eosinophils. 5-oxo-ETE inhibits selenium-induced apoptosis in prostate cancer cells. 5-oxo-ETE can be used in research into asthma, allergic diseases, cancer and cardiovascular disease .
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- HY-B0462AS
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- HY-B0539
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Desloratadine
Maximum Cited Publications
8 Publications Verification
Sch34117
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Histamine Receptor
TNF Receptor
Leukotriene Receptor
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Inflammation/Immunology
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Desloratadine (Sch34117) is an orally active and selective H1 receptor antagonist (Ki=0.9 nM) with anti-inflammatory and anti-allergic activities. Desloratadine inhibits the release of histamine and LTC4 from human basophils and targets the regulatory signals of IL-4 and IL-13 production in basophils. Desloratadine significantly alleviates SAR symptoms in patients with concurrent asthma and can be used in the study of seasonal allergic rhinitis and chronic idiopathic urticaria .
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- HY-13693R
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Sch32088 (Standard)
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Glucocorticoid Receptor
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Inflammation/Immunology
Endocrinology
Cancer
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Mometasone furoate (Standard) is the analytical standard of Mometasone furoate. This product is intended for research and analytical applications. Mometasone furoate (Sch32088) is a?glucocorticoid receptor?agonist with anti-inflammatory and anti-allergic activity. Mometasone furoate acts as a corticosteroid agent and used for topical applications in chronic skin eczema and airway inflammation management of asthma in vivo
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- HY-B0462S
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- HY-15770
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Integrin
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Inflammation/Immunology
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TR-14035 is a orally active dual α4β7/α4β1 integrin antagonist, with IC50 s of 7 nM and 87 nM for α4β7 and α4β1, respectively. TR-14035 can be used for the research of inflammation and autoimmune diseases .
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- HY-B0154R
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- HY-B0154
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- HY-103158
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Lipoxygenase
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Others
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BW B70C is a potent, selective and orally activearachidonic acid 5-lipoxygenase inhibitor. BW B70C inhibits both acute and allergic bronchoconstriction and late-phase eosinophil accumulation subsequent to allergen inhalation in guinea-pigs. BW B70C prevents leukotriene C4 synthesis and reduces leucocyte migration to the airways lumen as well as albumin microvascular leakage. BW B70C has the potential for the research of anti-asthma agent .
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- HY-148093
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STAT
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Inflammation/Immunology
Cancer
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PM-81I is a potent STAT6 inhibitor (targeting the SH2 structural domain) that effectively reduces STAT6 phosphorylation levels. PM-81I can be used in studies of allergic lung disease, allergic rhinitis, chronic obstructive pulmonary disease or cancer [1] sup>.
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- HY-116522
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- HY-N1193
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NF-κB
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Inflammation/Immunology
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Sulfuretin inhibits the inflammatory response by suppressing the NF-κB pathway. Sulfuretin can be used for the research of allergic airway inflammation. Sulfuretin reduces oxidative stress, platelet aggregation, and mutagenesis . Sulfuretin is a competitive and potent inhibitor of monophenolase and diphenolase activities with the IC50 of 13.64 μM .
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Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P4971
-
|
Complement System
|
Inflammation/Immunology
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C5a Anaphylatoxin (human) is a pro-inflammatory peptide and a leukocyte chemoattractant. C5a Anaphylatoxin (human) can be used to study inflammation and immunity, such as allergic asthma .
|
-
- HY-P1111A
-
|
Src
Interleukin Related
|
Inflammation/Immunology
|
Lyn peptide inhibitor TFA is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor TFA blocks Lyn activation and inhibits the binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors. Lyn peptide inhibitor TFA can be used for study of asthma, allergic, and other eosinophilic disorders .
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Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P9950
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Olizumab; rhuMab-E25
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Inhibitory Antibodies
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Inflammation/Immunology
Cancer
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Omalizumab is a recombinant, humanized, monoclonal antibody against human immunoglobulin E (IgE) with a KD of 0.393 nM. Omalizumab binds to the human FcγRIIb receptors with a KD of 6.37 uM. Omalizumab has the potential for persistent allergic asthma research .
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- HY-P99496
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RPC 4046; ABT 308; CC-93538
|
Interleukin Related
|
Inflammation/Immunology
|
Cendakimab (RPC4046; ABT 308; CC-93538) is a selective, humanized, recombinant monoclonal antibody against the IL-13 molecule. Cendakimab has a high affinity and potency for both human wild-type and variant IL-13 and blocks binding of IL-13 to both IL-13Rα1 and IL-13Rα2 with IC50s of 352 pM and 631 pM by ELISA, respectively. Cendakimab recognizes both wild-type human IL-13 and the common polymorphic variant R110Q, with binding affinities of 52 and 50 pM, respectively. Cendakimab has the potential for IL-13-related allergic/inflammatory diseases (e.g., asthma and eosinophilic esophagitis) .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-B1619S
-
|
Cromoglicic acid-d5 is the deuterium labeled Cromolyn[1]. Cromolyn is a mast cell stabilizer. Cromolyn has the potential for the research of bronchial asthma, allergic rhinitis, and certain allergic eye conditions such as vernal conjunctivitis, keratitis, and keratoconjunctivitis[2].
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- HY-B0462AS
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Azelastine- 13C,d3 is deuterium labeled Azelastine. Azelastine, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2[1][2][3][4].
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- HY-B0462S
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Azelastine- 13C,d3 (hydrochloride) is the 13C- and deuterium labeled Azelastine hydrochloride. Azelastine- 13C,d3 (hydrochloride), an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine- 13C,d3 (hydrochloride) can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2[1][2][3][4].
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