2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation Apoptosis
  3. Histamine Receptor TNF Receptor Leukotriene Receptor
  4. Desloratadine

Desloratadine  (Synonyms: Sch34117)

Cat. No.: HY-B0539 Purity: 99.83%
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Desloratadine (Sch34117) is an orally active and selective H1 receptor antagonist (Ki=0.9 nM) with anti-inflammatory and anti-allergic activities. Desloratadine inhibits the release of histamine and LTC4 from human basophils and targets the regulatory signals of IL-4 and IL-13 production in basophils. Desloratadine significantly alleviates SAR symptoms in patients with concurrent asthma and can be used in the study of seasonal allergic rhinitis and chronic idiopathic urticaria.

For research use only. We do not sell to patients.

Desloratadine Chemical Structure

Desloratadine Chemical Structure

CAS No. : 100643-71-8

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 45 In-stock
Solution
10 mM * 1 mL in DMSO USD 45 In-stock
Solid
25 mg USD 25 In-stock
50 mg USD 41 In-stock
100 mg USD 70 In-stock
250 mg USD 145 In-stock
500 mg USD 247 In-stock
1 g USD 420 In-stock
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Customer Review

Based on 10 publication(s) in Google Scholar

Other Forms of Desloratadine:

Desloratadine Related Antibodies

Top Publications Citing Use of Products

    Desloratadine purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 Nov 10;13(1):6796.  [Abstract]

    10 µM Amoxapine (Amo), Desloratadine (Desl) and Maprotiline (Map) are incubated with HEK293T cells for 24 h and significantly inhibits PERK phosphorylation and expression of ATF4 and CHOP .

    View All Histamine Receptor Isoform Specific Products:

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    H1 Receptor H2 Receptor H3 Receptor H4 Receptor Histamine Receptor

    View All TNF Receptor Isoform Specific Products:

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    TNFRSF1A/CD120a TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

    View All Leukotriene Receptor Isoform Specific Products:

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    LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Desloratadine (Sch34117) is an orally active and selective H1 receptor antagonist (Ki=0.9 nM) with anti-inflammatory and anti-allergic activities. Desloratadine inhibits the release of histamine and LTC4 from human basophils and targets the regulatory signals of IL-4 and IL-13 production in basophils. Desloratadine significantly alleviates SAR symptoms in patients with concurrent asthma and can be used in the study of seasonal allergic rhinitis and chronic idiopathic urticaria[1][2][3][4][5][6].

    IC50 & Target[1]

    H1 Receptor

     

    Human Endogenous Metabolite

     

    In Vitro

    Desloratadine (300 nmol/L-100 µmol/L) inhibits the release or production of multiple inflammatory mediators in cells with high affinity receptors for IgE[1].
    Desloratadine (1-10 μM, 15 min) has an inhibitory effect on IGE-induced IL-4 and IL-13 secretion that is nearly 6-7 times greater than its inhibitory effect on histamine and LTC4 release[2].
    Desloratadine (0.1-10 μmol/L, 1 h) dose-dependently inhibits platelet-activating factor (PAF)-induced eosinophil chemotaxis and TNF-α-induced eosinophil adhesion to human umbilical vein endothelial cells[5].
    Desloratadine (1, 10 and 50 μM, 30 min) inhibits the activation of eosinophils and mast cells in polyp tissues of patients with chronic sinusitis[6].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Desloratadine Related Antibodies
    In Vivo

    Desloratadine inhibits histamine-induced paw edema in a mouse inflammatory model in a dose-dependent manner (ED50=0.15 mg/kg; p.o.) and dose-dependently reduces the number of coughs after ovalbumin (HY-W250978) sensitization and antigen challenge in sensitized guinea pigs (the minimum effective antitussive dose is 0.3 mg/kg)[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    310.82

    Formula

    C19H19ClN2
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    ClC1=CC=C2C(CCC3=CC=CN=C3/C2=C4CCNCC/4)=C1
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 2 years
    -20°C 1 year
    Solvent & Solubility
    In Vitro: 

    DMSO : 25 mg/mL (80.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.2173 mL 16.0865 mL 32.1730 mL
    5 mM 0.6435 mL 3.2173 mL 6.4346 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    • Molarity Calculator

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    Volume (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.5 mg/mL (8.04 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.5 mg/mL (8.04 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
    Tween-80 +
    %
    Saline
    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.83%

    COA (254 KB) LCMS (99 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.2173 mL 16.0865 mL 32.1730 mL 80.4324 mL
    5 mM 0.6435 mL 3.2173 mL 6.4346 mL 16.0865 mL
    10 mM 0.3217 mL 1.6086 mL 3.2173 mL 8.0432 mL
    15 mM 0.2145 mL 1.0724 mL 2.1449 mL 5.3622 mL
    20 mM 0.1609 mL 0.8043 mL 1.6086 mL 4.0216 mL
    25 mM 0.1287 mL 0.6435 mL 1.2869 mL 3.2173 mL
    30 mM 0.1072 mL 0.5362 mL 1.0724 mL 2.6811 mL
    40 mM 0.0804 mL 0.4022 mL 0.8043 mL 2.0108 mL
    50 mM 0.0643 mL 0.3217 mL 0.6435 mL 1.6086 mL
    60 mM 0.0536 mL 0.2681 mL 0.5362 mL 1.3405 mL
    80 mM 0.0402 mL 0.2011 mL 0.4022 mL 1.0054 mL
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    Desloratadine Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Desloratadine100643-71-8Sch34117Sch 34117Sch-34117Histamine ReceptorTNF ReceptorLeukotriene ReceptorTumor Necrosis Factor ReceptorTNFRInhibitorinhibitorinhibit

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