2. Apoptosis Neuronal Signaling Immunology/Inflammation GPCR/G Protein
  3. Apoptosis Histamine Receptor
  4. Chloropyramine

Chloropyramine is competitive reversible H1 receptor antagonist. Chloropyramine also has anti-tumour activity in breast cancer. Chloropyramine can be used for the research of allergic conditions, such as conjunctivitis and bronchial asthma.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Chloropyramine hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Chloropyramine Chemical Structure

Chloropyramine Chemical Structure

CAS No. : 59-32-5

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Chloropyramine Related Antibodies

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Description

Chloropyramine is competitive reversible H1 receptor antagonist. Chloropyramine also has anti-tumour activity in breast cancer. Chloropyramine can be used for the research of allergic conditions, such as conjunctivitis and bronchial asthma[1][2].

IC50 & Target[1]

H1 Receptor

 

In Vitro

Chloropyramine (25, 50 μM; 24 h, 48 h) induces SASH1 expression and apoptosis in breast cancer cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chloropyramine Related Antibodies

Western Blot Analysis[1]

Cell Line: Breast cancer cell lines
Concentration: 25 or 50 μM
Incubation Time: 24 h
Result: Increased SASH1 expression in breast cancer cell lines.

Apoptosis Analysis[1]

Cell Line: T47D, MDA-MB-231 and BT-54 cells
Concentration: 50 μM
Incubation Time: 48 h
Result: Induced apoptosis in breast cancer cell lines.
In Vivo

Chloropyramine (i.p.; 10 mg/kg) abolishes hypothermia in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats[2]
Dosage: 10 mg/kg
Administration: Intraperitoneal
Result: Reduced histamine-induced hypothermia.
Molecular Weight

289.80

Formula

C16H20ClN3
CAS No.
SMILES

CN(CCN(C1=CC=CC=N1)CC2=CC=C(Cl)C=C2)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Chloropyramine Related Classifications

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chloropyramine59-32-5ApoptosisHistamine ReceptorH1 receptoranti-tumourallergic conditionsapoptosisconjunctivitisbronchial asthmaT47D cellsMDA-MB-231 cellsBT-54 cellsInhibitorinhibitorinhibit

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