Chloropyramine

Cat. No.: HY-119995: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Chloropyramine is competitive reversible H1 receptor antagonist. Chloropyramine also has anti-tumour activity in breast cancer. Chloropyramine can be used for the research of allergic conditions, such as conjunctivitis and bronchial asthma.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Chloropyramine hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Chloropyramine Chemical Structure

CAS No. : 59-32-5

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Chloropyramine:

Chloropyramine hydrochloride

Other Forms of Chloropyramine:

Chloropyramine hydrochloride In-stock

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Histamine Receptor Isoform Specific Products:

View All Isoforms

H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Histamine Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

H₁ Receptor

Cellular Effect

Cell Line	Type	Value	Description	References
MCF-10A	IC₅₀	> 60 μM Compound: 1	Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 35569251]
MDA-MB-157	IC₅₀	43.06 μM Compound: 1	Antiproliferative activity against human MDA-MB-157 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-157 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 35569251]
MDA-MB-231	IC₅₀	49.73 μM Compound: 1	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 35569251]
MDA-MB-453	IC₅₀	> 60 μM Compound: 1	Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay Antiproliferative activity against human MDA-MB-453 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay	[PMID: 35569251]

In Vitro

Chloropyramine (25, 50 μM; 24 h, 48 h) induces SASH1 expression and apoptosis in breast cancer cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	Breast cancer cell lines
Concentration:	25 or 50 μM
Incubation Time:	24 h
Result:	Increased SASH1 expression in breast cancer cell lines.

Apoptosis Analysis^[1]

Cell Line:	T47D, MDA-MB-231 and BT-54 cells
Concentration:	50 μM
Incubation Time:	48 h
Result:	Induced apoptosis in breast cancer cell lines.

In Vivo

Chloropyramine (i.p.; 10 mg/kg) abolishes hypothermia in rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rats^[2]
Dosage:	10 mg/kg
Administration:	Intraperitoneal
Result:	Reduced histamine-induced hypothermia.

Molecular Weight

289.80

Formula

C₁₆H₂₀ClN₃

CAS No.

59-32-5

SMILES

CN(CCN(C1=CC=CC=N1)CC2=CC=C(Cl)C=C2)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Joshua T Burgess, et al. SASH1 mediates sensitivity of breast cancer cells to chloropyramine and is associated with prognosis in breast cancer. Oncotarget. 2016 Nov 8;7(45):72807-72818. [Content Brief]

Chloropyramine Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chloropyramine59-32-5ApoptosisHistamine ReceptorH1 receptoranti-tumourallergic conditionsapoptosisconjunctivitisbronchial asthmaT47D cellsMDA-MB-231 cellsBT-54 cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks