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anti-prion activity

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-114621
    DB772

    		Flavivirus Infection
    DB772 hydrate is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 also has anti-prion activity .
    DB772
  • HY-114621A
    DB772 hydrate

    		Flavivirus Infection
    DB772 hydrate is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 also has anti-prion activity .
    DB772 hydrate
  • HY-111022
    Icerguastat

    Sephin1; IFB-088

    		 Phosphatase Infection Inflammation/Immunology
    Icerguastat (Sephin1), a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect .
    Icerguastat
  • HY-150514
    ARN1468

    		Others Infection
    ARN1468 (compound 5) is an orally active and potent serpins inhibitor. ARN1468 can inhibit serpins activity would set the protease free to further reduce prion accumulation. ARN1468 shows anti-prion effect in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC50 values of 8.64, 19.3, 11.2, and 6.27 μM .
    ARN1468
  • HY-13735D
    d-Atabrine dihydrochloride

    		Bacterial Infection
    d-Atabrine dihydrochloride is an active enantiomer of quinacrine which displays antiprion activity.
    d-Atabrine dihydrochloride
  • HY-13735C
    l-Atabrine dihydrochloride

    		Bacterial Infection
    l-Atabrine dihydrochloride is a less active enantiomer of quinacrine which displays antiprion activity.
    l-Atabrine dihydrochloride
  • HY-114621B
    DB772 free base

    		Flavivirus Infection
    DB772 free base is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 free base also has anti-prion activity .
    DB772 free base
  • HY-100857
    PrPSc-IN-1

    		Fluorescent Dye Neurological Disease
    PrPSc-IN-1 is a fluorescent probe, binds to the misfolded protein PrP Sc, inhibits its accumulation, with an IC50 of 1.6 μM. Anti-prion activity .
    PrPSc-IN-1
  • HY-110365
    Icerguastat Carbonate

    Sephin1 Carbonate; IFB-088 Carbonate

    		 Phosphatase Infection
    Icerguastat (Sephin1) Carbonate, a derivative of Guanabenz lacking the α2-adrenergic activity, is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A). Icerguastat Carbonate inhibits eIF2α dephosphorylation, thereby prolonging the protective response. Anti-prion effect .
    Icerguastat Carbonate
  • HY-147702
    BB 0305179

    		Others Infection Neurological Disease
    BB 0305179 (compound 59) is a potent anti-prion agent, with an IC50 of 4.7 μM. BB 0305179 inhibits the toxicity of a specific PrP mutant carrying a deletion in the hydrophobic domain . BB 0305179 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    BB 0305179
  • HY-147371
    Quinoprazine

    		Parasite Infection Neurological Disease
    Quinoprazine is a potent inhibitor of Vaccinia virus DNA synthesis with an IC50 value of 10 μM. Quinoprazine has antimalarial activity against Plasmodium berghei and also displays antiprion potency, significantly decreases PrP S c levels - .
    Quinoprazine
  • HY-134561
    6-Amino-8-trifluoromethylphenanthridine

    6A-8tFP

    		 Others Infection
    6-Amino-8-trifluoromethylphenanthridine (6A-8tFP) is an antiprion agent and a derivative of 6-aminophenanthridine (HY-135189). It inhibits protein folding activity of the ribosome (PFAR) when used at a concentration of 150 μM.2 6A-8tFP directly competes with protein substrates for the ribosomal active site.
    6-Amino-8-trifluoromethylphenanthridine

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