2. Anti-infection
  3. Flavivirus
  4. DB772

DB772 hydrate is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 also has anti-prion activity.

For research use only. We do not sell to patients.

DB772 Chemical Structure

DB772 Chemical Structure

CAS No. : 1451058-50-6

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of DB772:

DB772 Related Antibodies

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Description

DB772 hydrate is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 also has anti-prion activity[1].

In Vitro

DB772 hydrate (0-100 μM, 96 hours) can inhibit replication of the viruses BVDV2 and BDV at concentrations greater than 0.2 μM, Bungowannah virus replication at concentrations greater than 0.01 μM, and HoBi virus replication greater than 1.65 μM[2].
DB772 hydrate has antiprion activity with CC50 (50% cytotoxic concentration) value of 3.8 μM, TC-EC50 (50% tissue culture effective concentration) value of 0. 8 μM and inhibits PrPSc accumulation in sheep microglia[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DB772 Related Antibodies

Cell Viability Assay[3]

Cell Line: PrPSc-positive and -negative cell lines of human telomerase-immortalized (hTERT) ovine microglia
Concentration: 1 μM
Incubation Time: 4 days
Result: Showed no significant effect on cell viability with 96.4% cell viability.
Significantly reduced PrPSc-positive spots by 65.8% and completely inhibited PrPSc accumulation in scrapie-infected primary ovine microglia at 4 μM.
Molecular Weight

401.29

Formula

C20H18Cl2N4O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

[H]Cl.[H]Cl.C1(C2=CC=C(C3=CC=C(C4=NCCN4)C=C3)O2)=NC5=CC=CC=C5N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (24.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4920 mL 12.4598 mL 24.9196 mL
5 mM 0.4984 mL 2.4920 mL 4.9839 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4920 mL 12.4598 mL 24.9196 mL 62.2991 mL
5 mM 0.4984 mL 2.4920 mL 4.9839 mL 12.4598 mL
10 mM 0.2492 mL 1.2460 mL 2.4920 mL 6.2299 mL
15 mM 0.1661 mL 0.8307 mL 1.6613 mL 4.1533 mL
20 mM 0.1246 mL 0.6230 mL 1.2460 mL 3.1150 mL
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DB772 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DB7721451058-50-6DB 772DB-772FlavivirusbovineviraldiarrheavirusInhibitorinhibitorinhibit

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