2. Anti-infection
  3. Flavivirus
  4. DB772 hydrate

DB772 hydrate is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 also has anti-prion activity.

For research use only. We do not sell to patients.

DB772 hydrate Chemical Structure

DB772 hydrate Chemical Structure

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5 mg USD 350 In-stock
10 mg USD 600 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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DB772 hydrate Related Antibodies

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Description

DB772 hydrate is a bovine viral diarrhoea virus (BVDV) inhibitor. DB772 also has anti-prion activity[1].

In Vitro

DB772 hydrate (0-100 μM, 96 hours) can inhibit replication of the viruses BVDV2 and BDV at concentrations greater than 0.2 μM, Bungowannah virus replication at concentrations greater than 0.01 μM, and HoBi virus replication greater than 1.65 μM[2].
? DB772 hydrate has antiprion activity with CC50 (50% cytotoxic concentration) value of 3.8 μM, TC-EC50 (50% tissue culture effective concentration) value of 0. 8 μM and inhibits PrPSc accumulation in sheep microglia[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DB772 hydrate Related Antibodies

Cell Viability Assay[3]

Cell Line: PrPSc-positive and -negative cell lines of human telomerase-immortalized (hTERT) ovine microglia
Concentration: 1 μM
Incubation Time: 4 days
Result: Showed no significant effect on cell viability with 96.4% cell viability.
Significantly reduced PrPSc-positive spots by 65.8% and completely inhibited PrPSc accumulation in scrapie-infected primary ovine microglia at 4 μM.
Molecular Weight

502.54

Formula

C20H19ClN4O2
Appearance

Solid

Color

Light yellow to yellow

SMILES

[H]Cl.C1(C2=CC=C(C3=CC=C(C4=NCCN4)C=C3)O2)=NC5=CC=CC=C5N1.[2.8].[4].O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 4 mg/mL (7.96 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9899 mL 9.9495 mL 19.8989 mL
5 mM 0.3980 mL 1.9899 mL 3.9798 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Purity & Documentation

Purity: 99.89%

Data Sheet (276 KB) SDS (252 KB)

COA (253 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9899 mL 9.9495 mL 19.8989 mL 49.7473 mL
5 mM 0.3980 mL 1.9899 mL 3.9798 mL 9.9495 mL
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DB772 hydrate Related Classifications

Keywords:

DB772DB 772DB-772FlavivirusbovineviraldiarrheavirusInhibitorinhibitorinhibit

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DB772 hydrate
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SAFETY DATA SHEET (SDS)

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