l-Atabrine dihydrochloride

Name: l-Atabrine dihydrochloride
Brand: MedChemExpress
SKU: HY-13735C
Rating: 4.5 (1 reviews)

Cat. No.: HY-13735C Purity: 98.35%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

l-Atabrine dihydrochloride is a less active enantiomer of quinacrine which displays antiprion activity.

For research use only. We do not sell to patients.

l-Atabrine dihydrochloride Chemical Structure

CAS No. : 56100-42-6

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 66	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 66	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 38	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of l-Atabrine dihydrochloride:

Quinacrine dihydrochloride In-stock
d-Atabrine dihydrochloride In-stock
Quinacrine Get quote
Quinacrine hydrochloride hydrate Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

l-Atabrine dihydrochloride is a less active enantiomer of quinacrine which displays antiprion activity.

Molecular Weight

472.88

Formula

C₂₃H₃₂Cl₃N₃O

CAS No.

56100-42-6

Appearance

Solid

Color

Light yellow to yellow

SMILES

C[C@@H](NC1=C(C=C(OC)C=C2)C2=NC3=CC(Cl)=CC=C31)CCCN(CC)CC.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 50 mg/mL (105.74 mM; Need ultrasonic)

DMSO : 20 mg/mL (42.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1147 mL	10.5735 mL	21.1470 mL
5 mM	0.4229 mL	2.1147 mL	4.2294 mL
10 mM	0.2115 mL	1.0574 mL	2.1147 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2 mg/mL (4.23 mM); Clear solution

This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2 mg/mL (4.23 mM); Clear solution

This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2 mg/mL (4.23 mM); Clear solution

This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 98.35%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (250 KB) LCMS (97 KB)

Handling Instructions (2659 KB)

References

[1]. Ryou C, et al. Differential inhibition of prion propagation by enantiomers of quinacrine. Lab Invest. 2003 Jun;83(6):837-43. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.1147 mL	10.5735 mL	21.1470 mL	52.8675 mL
	5 mM	0.4229 mL	2.1147 mL	4.2294 mL	10.5735 mL
	10 mM	0.2115 mL	1.0574 mL	2.1147 mL	5.2868 mL
	15 mM	0.1410 mL	0.7049 mL	1.4098 mL	3.5245 mL
	20 mM	0.1057 mL	0.5287 mL	1.0574 mL	2.6434 mL
	25 mM	0.0846 mL	0.4229 mL	0.8459 mL	2.1147 mL
	30 mM	0.0705 mL	0.3525 mL	0.7049 mL	1.7623 mL
	40 mM	0.0529 mL	0.2643 mL	0.5287 mL	1.3217 mL
H₂O	50 mM	0.0423 mL	0.2115 mL	0.4229 mL	1.0574 mL
	60 mM	0.0352 mL	0.1762 mL	0.3525 mL	0.8811 mL
	80 mM	0.0264 mL	0.1322 mL	0.2643 mL	0.6608 mL
	100 mM	0.0211 mL	0.1057 mL	0.2115 mL	0.5287 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.