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carboxylesterases

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Carboxylesterase (21) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (2) Apoptosis (2) Autophagy (4) Bacterial (2) Biochemical Assay Reagents (1) Cholinesterase (ChE) (1) DNA/RNA Synthesis (1) Drug Metabolite (1) Fluorescent Dye (3) HDAC (1) Isotope-Labeled Compounds (1) Opioid Receptor (2) p38 MAPK (2) Reactive Oxygen Species (1) UGT (2) Wnt (3)
By Research Areas:	Cancer (13) Cardiovascular Disease (4) Infection (5) Inflammation/Immunology (5) Metabolic Disease (12) Neurological Disease (5)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Carboxylesterase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-142688

Carboxylesterase-IN-2	Carboxylesterase Wnt	Cancer
Carboxylesterase-IN-2 (compound 4u) is a potent inhibitor of Carboxylesterase Notum with an IC₅₀ less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-2 has the potential for the research of cancer disease .

HY-142689

Carboxylesterase-IN-3	Carboxylesterase Wnt	Cancer
Carboxylesterase-IN-3 (compound 4y) is a potent inhibitor of Carboxylesterase Notum with an IC₅₀ less than or equal to 10 nM. Notum is a negative regulator of Wnt signaling acting through the hydrolysis of a palmitoleoylate ester, which is required for Wnt activity. Carboxylesterase-IN-3 has the potential for the research of cancer disease .

HY-N10686

Tanshinone IIA anhydride	Carboxylesterase	Cancer
Tanshinone IIA anhydride is a potent and irreversible human carboxylesterase (CE) inhibitor with K_i values of 1.9 nM and 1.4 nM for human CE1 and the human intestinal CE (hiCE), respectively .

HY-144809

*Pancreatic lipase/Carboxylesterase* 1-IN-1**	Carboxylesterase	Metabolic Disease
Pancreatic lipase/Carboxylesterase 1-IN-1 (Compound 39) is a potent dual inhibitor of pancreatic lipase (PL) and *human carboxylesterase* 1A (hCES1A) with IC₅₀** values of 2.13 µM and 0.055 µM against PL and hCES1A .

HY-N3413

Kushenol X	Carboxylesterase	Metabolic Disease
Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent β-glucuronidase and *human carboxylesterase* 2 (hCE2) inhibitor with IC₅₀**s of 2.07 μM and 3.05 μM, respectively .

HY-N3921

Gancaonin I	Carboxylesterase	Cancer
Gancaonin I, an Isoflavone, exhibits moderate inhibition on *human carboxylesterase* 2 (hCES2A**) with IC₅₀ of 1.72 μM. Gancaonin I inhibits hCES2A-mediated fluorescein diacetate (FD) hydrolysis .

HY-W354821

4-Methylumbelliferyl Decanoate 4-MUD	Fluorescent Dye	Metabolic Disease
4-Methyl-2-oxo-2H-1-benzopyran-7-yl decanoate is a fluorogenic substrate used to follow the hydrolytic activity of carboxylesterases .

HY-147331

Oseltamivir acid methyl ester	Antibiotic Carboxylesterase	Neurological Disease
Oseltamivir acid methyl ester is a precursor form of the neuraminidase inhibitor and antiviral oseltamivir acid. Oseltamivir acid methyl ester is converted to oseltamivir acid by carboxylesterase 1 (CES1) .

HY-147331A

Oseltamivir acid methyl ester hydrochloride	Antibiotic Carboxylesterase	Neurological Disease
Oseltamivir acid methyl ester hydrochloride is a precursor form of the neuraminidase inhibitor and antiviral oseltamivir acid. Oseltamivir acid methyl ester hydrochloride is converted to oseltamivir acid by carboxylesterase 1 (CES1) .

HY-147915

Benz-AP	Carboxylesterase Reactive Oxygen Species	Cancer
Benz-AP is a potent photosensitizer. Benz-AP produces singlet oxygen, with a negative correlation with hCES2 (Human carboxylesterase 2) activity. Benz-AP displays a higher photocytotoxicity potency in cancer cells under low hCES2 environments. Upon TPE (Two-photon excitation), Benz-AP produces ROS and kills cancer cells and tumor spheroids .

HY-141834

Carboxylesterase-IN-1	Carboxylesterase	Others
Carboxylesterase-IN-1, a novel pesticide, exhibits inhibitory action on carboxylesterase at 50 μg/mL similar to the known inhibitor triphenyl phosphate.

HY-106409

Tefinostat 1 Publications Verification CHR-2845	HDAC Apoptosis	Cancer
Tefinostat (CHR-2845) is a monocyte/macrophage targeted histone deacetylase (HDAC) inhibitor. Tefinostat can be cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat can be used for the research of leukaemias .

HY-W341421

3-Indoxyl butyrate	Biochemical Assay Reagents	Others
3-Indoxyl butyrate is a chromogenic substrate for CES (carboxylesterase), producing a blue precipitate upon cleavage.

HY-162502

WZU-13	Carboxylesterase Wnt	Cancer
WZU-13 is an inhibitor for Carboxylesterase (CES). WZU-13 inhibits 77% CES activity at a dose of 100 μM .

HY-N3474

Isolicoflavonol	Carboxylesterase	Others
Isolicoflavonol potently inhibits *hCES2A (Human carboxylesterase* 2)**-mediated fluorescein diacetate hydrolysis in a reversible and mixed inhibition manner, with Ki values less than 1.0 μM .

HY-120602

WWL229	Carboxylesterase	Metabolic Disease
WWL229 is a selective inhibitor of carboxylesterase 3 (Ces3) with an IC₅₀ of 1.94 µM. WWL229 promotes lipid storage in cultured adipocytes and prevents basal lipolysis .

HY-131922

Iso-OMPA Tetraisopropyl pyrophosphoramide	Cholinesterase (ChE)	Neurological Disease
Iso-OMPA (Tetraisopropyl pyrophosphoramide) is a selective inhibitor of the irreversible butyrylcholinesterase (BuChE). Iso-OMPA enhances soman toxicity in rats associated with the inhibition of plasma carboxylesterase (CarbE) .

HY-B0418A

Loperamide hydrochloride 5 Publications Verification R-18553 hydrochloride	Opioid Receptor Autophagy	Neurological Disease Metabolic Disease Cancer
Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an opioid receptor agonist . Loperamide hydrochloride is a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor. Loperamide hydrochloride has anti-diarrheal effect .

HY-169068

Antifeedant agent 1	Carboxylesterase	Infection
Antifeedant agent 1 is a *carboxylesterase* inhibitor that exerts insecticidal activity by inhibiting insect feeding, with an EC₅₀ value of 0.038 mg/mL. Antifeedant agent 1 can be used in research related to pest control .

HY-124104

Aldicarb sulfoxide	Drug Metabolite	Cardiovascular Disease Metabolic Disease
Aldicarb sulfoxide is a metabolite of Aldicarb. Aldicarb sulfoxide affects the glutathione-linked enzymes in CHO-K1 cells. Aldicarb sulfoxide inhibits cholinesterase (ChE) and carboxylesterase (CaE) with IC₅₀ of 10 μM for both in zebrafish .

HY-N1377

Nevadensin	Carboxylesterase Bacterial	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1 (hCE1) with an IC₅₀ of 2.64 μM. Nevadensin has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and anti-hypertensive .

HY-B0418AR

Loperamide hydrochloride (Standard) 5 Publications Verification R-18553 hydrochloride (Standard)	Opioid Receptor Autophagy	Neurological Disease Metabolic Disease Cancer
Loperamide (hydrochloride) (Standard) is the analytical standard of Loperamide (hydrochloride). This product is intended for research and analytical applications. Loperamide (hydrochloride) (R-18553 (hydrochloride)) is an opioid receptor agonist . Loperamide hydrochloride is a selective and competitive human intestinal carboxylesterases (hiCE) inhibitor. Loperamide hydrochloride has anti-diarrheal effect .

HY-155228

LK-44	Others	Inflammation/Immunology
hCES2A-IN-2 (Compound 44) is an orally active human carboxylesterase 2 (hCES2A) inhibitor (IC₅₀: 5.02 μM). hCES2A-IN-2 improves Irinotecan (HY-16562)-induced delayed diarrhea .

HY-114879

DDAO 1 Publications Verification	Fluorescent Dye Carboxylesterase	Cancer
DDAO is a promising near-infrared (NIR) red fluorescent probewith tunable excitation wavelength (600-650nm) and longemission wavelength(λem=656nm). DDAO can de desiged for detection of the activities of different enzymes such asβ-galactosidase,sulfatase, proteinphosphatase2A,carboxylesterase 2, humanalbumin andesterases .

HY-D1739

DDAO phosphate diammonium	Fluorescent Dye Carboxylesterase	Others
DDAO phosphate diammonium is a fluorescent phosphatase substrate. DDAO phosphate diammonium has tunable excitation wavelength (600-650nm) and long emission wavelength (λem=656nm). DDAO phosphate diammonium can be used to detect the activity of different enzymes such as β-galactosidase, sulfatase, protein phosphatase 2A, carboxylesterase 2, human albumin and esterase.

HY-N1377R

Nevadensin (Standard)	Carboxylesterase Bacterial	Infection Metabolic Disease Inflammation/Immunology
Nevadensin (Standard) is the analytical standard of Nevadensin. This product is intended for research and analytical applications. Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1 (hCE1) with an IC₅₀ of 2.64 μM. Nevadensin has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and anti-hypertensive .

HY-124104S

Aldicarb sulfoxide-d3	Isotope-Labeled Compounds	Metabolic Disease
Aldicarb sulfoxide-d₃ is the deuterium labled Aldicarb sulfoxide (HY-124104). Aldicarb sulfoxide is a metabolite of Aldicarb. Aldicarb sulfoxide affects the glutathione-linked enzymes in CHO-K1 cells. Aldicarb sulfoxide inhibits cholinesterase (ChE) and carboxylesterase (CaE) with IC₅₀ of 10 μM for both in zebrafish .

HY-23148

1-Methylisatin N-Methylisatin	Carboxylesterase	Others
1-Methylisatin is a potent and selective CE (carboxylesterases) inhibitor, with K_is of 38.2 and 5.38 μM for hiCE and hCE1, respectively. 1-Methylisatin interacts with Hb (human adult hemoglobin) by hydrophobic binding and electrostatic attraction. 1-Methylisatin can be used in the study of regulation of agent metabolism in vivo .

HY-155070

SRE-II	DNA/RNA Synthesis Apoptosis	Cancer
SRE-II, an amide derivative, is an activatable photosensitizer for photodynamic cancer research with decreased fluorescence and photosensitizing capabilities. SRE-II can be further converted into the active photosensitizer SDU Red via carboxylesterase-catalyzed amide bond cleavage. SRE-II induces DNA damage and cell apoptosis in the presence of light. SRE-II can act as a promising theranostic agent for triple-negative breast cancer .

HY-N0235

Bakuchiol 2 Publications Verification (S)-(+)-Bakuchiol	Carboxylesterase p38 MAPK Autophagy UGT	Infection Metabolic Disease Inflammation/Immunology Cancer
Bakuchiol is a phytoestrogen that can be obtained from psoralen seeds. Bakuchiol has been proven to be a non-competitive inhibitor of multiple enzymes, including UDP-glucuronosyltransferase 2B7 (UGT2B7) and human carboxylesterase 2 (hCE2) , with IC₅₀s values of 40.9 μM and 7.28 μM, respectively. Bakuchiol exhibits significant research and application potential in areas such as anti-inflammatory , antibacterial , antitumor therapies, as well as drug metabolism regulation.

HY-N0235R

Bakuchiol (Standard)	Carboxylesterase p38 MAPK Autophagy UGT	Infection Metabolic Disease Inflammation/Immunology Cancer
Bakuchiol (Standard) is the analytical standard of Bakuchiol. This product is intended for research and analytical applications. Bakuchiol is a phytoestrogen that can be obtained from psoralen seeds. Bakuchiol has been proven to be a non-competitive inhibitor of multiple enzymes, including UDP-glucuronosyltransferase 2B7 (UGT2B7) and human carboxylesterase 2 (hCE2) , with IC₅₀s values of 40.9 μM and 7.28 μM, respectively. Bakuchiol exhibits significant research and application potential in areas such as anti-inflammatory , antibacterial , antitumor therapies, as well as drug metabolism regulation.

HY-B0384

Temocapril hydrochloride	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Temocapril hydrochloride is an orally active angiotensin-converting enzyme (ACE) inhibitor. Temocapril hydrochloride can be used for the research of hypertension, congestive heart failure, acute myocardial infarction, insulin resistance, and renal diseases .

HY-100713

Temocapril	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Temocapril is an orally active angiotensin-converting enzyme (ACE) inhibitor. Temocapril can be used for the research of hypertension, congestive heart failure, acute myocardial infarction, insulin resistance, and renal diseases .

Cat. No.	Product Name	Type

HY-114879

DDAO 1 Publications Verification	Fluorescent Dyes/Probes
DDAO is a promising near-infrared (NIR) red fluorescent probewith tunable excitation wavelength (600-650nm) and longemission wavelength(λem=656nm). DDAO can de desiged for detection of the activities of different enzymes such asβ-galactosidase,sulfatase, proteinphosphatase2A,carboxylesterase 2, humanalbumin andesterases .

HY-W354821

4-Methylumbelliferyl Decanoate 4-MUD	Chromogenic Substrates Fluorescent Dyes/Probes
4-Methyl-2-oxo-2H-1-benzopyran-7-yl decanoate is a fluorogenic substrate used to follow the hydrolytic activity of carboxylesterases .

HY-D1739

DDAO phosphate diammonium	Fluorescent Dyes/Probes
DDAO phosphate diammonium is a fluorescent phosphatase substrate. DDAO phosphate diammonium has tunable excitation wavelength (600-650nm) and long emission wavelength (λem=656nm). DDAO phosphate diammonium can be used to detect the activity of different enzymes such as β-galactosidase, sulfatase, protein phosphatase 2A, carboxylesterase 2, human albumin and esterase.

3-Indoxyl butyrate	Cell Assay Reagents
3-Indoxyl butyrate is a chromogenic substrate for CES (carboxylesterase), producing a blue precipitate upon cleavage.

Cat. No.	Product Name	Target	Research Area

HY-P2424

Cholecystokinin-J CCK-J	Peptides	Others
Cholecystokinin-J (CCK-J), a cholecystokinin, stimulates Ca ²⁺ release .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10686

Tanshinone IIA anhydride	Structural Classification Flavonoids Labiatae Samanea saman (Jacq.) Merr. Source classification Plants Other Flavonoids	Carboxylesterase
Tanshinone IIA anhydride is a potent and irreversible human carboxylesterase (CE) inhibitor with K_i values of 1.9 nM and 1.4 nM for human CE1 and the human intestinal CE (hiCE), respectively .

HY-N3413

Kushenol X	Flavanonols Structural Classification Flavonoids Classification of Application Fields Leguminosae Source classification Phenols Polyphenols Metabolic Disease Sophora flavescens Aiton Plants Disease Research Fields	Carboxylesterase
Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent β-glucuronidase and *human carboxylesterase* 2 (hCE2) inhibitor with IC₅₀**s of 2.07 μM and 3.05 μM, respectively .

HY-N3921

Gancaonin I	Structural Classification Flavonoids Classification of Application Fields Leguminosae Source classification Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Isoflavones Cancer	Carboxylesterase
Gancaonin I, an Isoflavone, exhibits moderate inhibition on *human carboxylesterase* 2 (hCES2A**) with IC₅₀ of 1.72 μM. Gancaonin I inhibits hCES2A-mediated fluorescein diacetate (FD) hydrolysis .

HY-N3474

Isolicoflavonol	Flavonols Structural Classification Flavonoids other families Classification of Application Fields Source classification Other Diseases Phenols Polyphenols Plants Disease Research Fields	Carboxylesterase
Isolicoflavonol potently inhibits *hCES2A (Human carboxylesterase* 2)**-mediated fluorescein diacetate hydrolysis in a reversible and mixed inhibition manner, with Ki values less than 1.0 μM .

HY-N1377

Nevadensin	Structural Classification Flavonoids other families Classification of Application Fields Flavones Source classification Phenols Polyphenols Metabolic Disease Plants Inflammation/Immunology Disease Research Fields	Carboxylesterase Bacterial
Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1 (hCE1) with an IC₅₀ of 2.64 μM. Nevadensin has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and anti-hypertensive .

HY-N0235

Bakuchiol 2 Publications Verification (S)-(+)-Bakuchiol	Structural Classification Monophenols Classification of Application Fields Leguminosae Source classification Phenols Psoralea corylifolia L. Plants Disease Research Fields Cancer	Carboxylesterase p38 MAPK Autophagy UGT
Bakuchiol is a phytoestrogen that can be obtained from psoralen seeds. Bakuchiol has been proven to be a non-competitive inhibitor of multiple enzymes, including UDP-glucuronosyltransferase 2B7 (UGT2B7) and human carboxylesterase 2 (hCE2) , with IC₅₀s values of 40.9 μM and 7.28 μM, respectively. Bakuchiol exhibits significant research and application potential in areas such as anti-inflammatory , antibacterial , antitumor therapies, as well as drug metabolism regulation.

HY-N1377R

Nevadensin (Standard)	Structural Classification Flavonoids other families Flavones Source classification Phenols Polyphenols Plants	Carboxylesterase Bacterial
Nevadensin (Standard) is the analytical standard of Nevadensin. This product is intended for research and analytical applications. Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1 (hCE1) with an IC₅₀ of 2.64 μM. Nevadensin has a variety of pharmacological effects such as anti-mycobacterium tuberculosis activities, antitussive, anti-inflammatory and anti-hypertensive .

HY-N0235R

Bakuchiol (Standard)	Structural Classification Monophenols Leguminosae Source classification Phenols Psoralea corylifolia L. Plants	Carboxylesterase p38 MAPK Autophagy UGT
Bakuchiol (Standard) is the analytical standard of Bakuchiol. This product is intended for research and analytical applications. Bakuchiol is a phytoestrogen that can be obtained from psoralen seeds. Bakuchiol has been proven to be a non-competitive inhibitor of multiple enzymes, including UDP-glucuronosyltransferase 2B7 (UGT2B7) and human carboxylesterase 2 (hCE2) , with IC₅₀s values of 40.9 μM and 7.28 μM, respectively. Bakuchiol exhibits significant research and application potential in areas such as anti-inflammatory , antibacterial , antitumor therapies, as well as drug metabolism regulation.

Cat. No.	Product Name	Chemical Structure

HY-124104S

Aldicarb sulfoxide-d3
Aldicarb sulfoxide-d₃ is the deuterium labled Aldicarb sulfoxide (HY-124104). Aldicarb sulfoxide is a metabolite of Aldicarb. Aldicarb sulfoxide affects the glutathione-linked enzymes in CHO-K1 cells. Aldicarb sulfoxide inhibits cholinesterase (ChE) and carboxylesterase (CaE) with IC₅₀ of 10 μM for both in zebrafish .

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carboxylesterases

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products