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disease angina

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adrenergic Receptor (9) Antibiotic (1) Apoptosis (11) Autophagy (1) Bcl-2 Family (1) Calcium Channel (4) Caspase (1) Dopamine Receptor (1) Endogenous Metabolite (2) Fungal (1) Guanylate Cyclase (1) Isotope-Labeled Compounds (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (2) Phospholipase (1) PI3K (1) Potassium Channel (3) Wee1 (1)
By Research Areas:	Cancer (11) Cardiovascular Disease (24) Endocrinology (7) Infection (6) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0341

Nicorandil SG-75	Potassium Channel	Cardiovascular Disease
Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K ⁺ channels and cardiac ATP-sensitive K ⁺ channels (K_ATP). Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases .

HY-B0341S

Nicorandil-d4	Isotope-Labeled Compounds Potassium Channel	Cardiovascular Disease
Nicorandil-d₄ (SG-75-d4) is the deuterium labeled Nicorandil. Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K+ channels and cardiac ATP-sensitive K+ channels (KATP). Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases[1][2][3].

HY-B1334A

Perhexiline maleate 2 Publications Verification	Mitochondrial Metabolism Apoptosis	Cardiovascular Disease Cancer
Perhexiline maleate is an orally active CPT1 and CPT2 inhibitor that reduces fatty acid metabolism. Perhexiline maleate induces mitochondrial dysfunction and apoptosis in hepatic cells. Perhexiline maleate can cross the blood brain barrier (BBB) and shows anti-tumor activity. Perhexiline maleate can be used in the research of cancers, and cardiovascular disease like angina .

HY-17583

Griseofulvin	Fungal Apoptosis Antibiotic Endogenous Metabolite Microtubule/Tubulin Wee1 Caspase Bcl-2 Family	Infection Cardiovascular Disease Cancer
Griseofulvin is an orally active antifungal antibiotic with antitumor activity. Griseofulvin induces apoptosis and G2/M cell cycle arrest in cancer cells. Griseofulvin also has cardiovascular modulatory activity, reducing angina pectoris, relieving hand artery spasm associated with onychomycosis, and peripheral vascular diseases such as shoulder-hand syndrome .

HY-B0642

Isosorbide mononitrate 4 Publications Verification Isosorbide-5-mononitrate	Autophagy Endogenous Metabolite Apoptosis	Cardiovascular Disease Cancer
Isosorbide mononitrate (Isosorbide-5-mononitrate) is an orally active nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure. Isosorbide mononitrate increases the viability and proliferation of HUVECs by decreasing Apoptosis and elevated the expressions of vedf, kdrl, pdgfr in zebrafish embryos. Isosorbide mononitrate is promising for research of heart failure and coronary heart disease .

HY-106239

Fostedil KB 944	Calcium Channel	Cardiovascular Disease
Fostedil (KB 944) is a calcium antagonist that can be used in the research of heart diseases such as angina pectoris .

HY-B0341R

Nicorandil (Standard)	Potassium Channel	Cardiovascular Disease
Nicorandil (Standard) is the analytical standard of Nicorandil. This product is intended for research and analytical applications. Nicorandil (SG-75) is a potent potassium channel activator and targets vascular nucleoside diphosphate-dependent K ⁺ channels and cardiac ATP-sensitive K ⁺ channels (K_ATP). Nicorandil is a nicotinamide ester with vasodilatory and cardioprotective effects and has the potential for angina and forischemic heart diseases .

HY-142698

SGC agonist 2	Guanylate Cyclase	Cardiovascular Disease
SGC agonist 2 is a potent agonist of soluble guanylate cyclase (SGC). Soluble guanylate cyclase is a key signal transduction enzyme in the NO-sGC-cGMP signaling pathway. SGC agonist 2 has the potential for the research of cardiovascular disease (heart failure, pulmonary hypertension, angina, myocardial infarction) and fibrotic diseases (renal fibrosis, systemic sclerosis) (extracted from patent WO2021219088A1, compound 031) .

HY-106904

Nexopamil	Calcium Channel 5-HT Receptor Dopamine Receptor	Cardiovascular Disease
Nexopamil is a calcium antagonist of Ca ²⁺ channel, 5HT₂, 5HT_1A, 5HT_1C and dopamine D₂ receptors. Nexopamil exhibits vasodilatory, cardioprotective, and platelet aggregation inhibiting effects. Nexopamil can be used for researches of stable or unstable angina and possibly of peripheral arterial occlusive disease .

HY-B1334

Perhexiline	Mitochondrial Metabolism Apoptosis	Cardiovascular Disease Cancer
Perhexiline is an orally active CPT1 and CPT2 inhibitor that reduces fatty acid metabolism. Perhexiline induces mitochondrial dysfunction and apoptosis in hepatic cells. Perhexiline can cross the blood brain barrier (BBB) and shows anti-tumor activity. Perhexiline can be used in the research of cancers, and cardiovascular disease like angina .

HY-107802

Breviscapine Breviscapinun	Others	Cardiovascular Disease
Breviscapine is a crude flavonoid extract of Breviscapine, which is more than 85% of the active ingredient, Breviscapine. Breviscapine has a wide range of cardiovascular pharmacological activities, such as increasing blood flow, improving microcirculation, dilating blood vessels, reducing blood viscosity, promoting fibrinolysis, inhibiting platelet aggregation and thrombosis. Breviscapine has been used in the study of cerebral infarction and its sequelae, cerebral thrombosis, coronary heart disease and angina pectoris .

HY-101390

(+)-Niguldipine hydrochloride (S)-Niguldipine hydrochloride	Calcium Channel	Cardiovascular Disease
(+)-Niguldipine hydrochloride is an antagonist for calcium channel. (+)-Niguldipine hydrochloride produces vasodilation by blocking calcium channels and reducing the transmembrane influx of calcium ions. (+)-Niguldipine hydrochloride inhibits U-46619 (HY-108566)-induced coronary vasoconstriction in guinea pig Langendorff heart with pID₅₀ of 11.37, binds to calcium channel on guinea pig skeletal muscle membrane with K_i of 9.75, and lowers the blood pressure in spontaneously hypertensive rat with pED₃₀ of 7.1. (+)-Niguldipine hydrochloride ameliorates cardiovascular diseases such as hypertension, angina pectoris and arrhythmias .

HY-101390A

(-)-Niguldipine hydrochloride (R)-Niguldipine hydrochloride	Calcium Channel	Cardiovascular Disease
(-)-Niguldipine ((R)-Niguldipine) hydrochloride is a calcium channel antagonist. (-)-Niguldipine hydrochloride exerts a vasodilatory effect by blocking calcium channels and reducing the transmembrane influx of calcium ions. (-)-Niguldipine can inhibit U-46619 (HY-108566)-induced coronary artery contraction in guinea pig Langendorff hearts (pID₅₀ of 9.93), has high affinity for calcium channel binding sites on guinea pig skeletal muscle membranes (K_i of 8.10), and lowers blood pressure in spontaneously hypertensive rats (pED₃₀ of 5.55). (-)-Niguldipine hydrochloride can improve cardiovascular diseases such as hypertension, angina pectoris, and arrhythmias .

HY-B1486

Oxprenolol hydrochloride 1 Publications Verification Ba 39089	Adrenergic Receptor	Cardiovascular Disease
Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a K_i of 7.10 nM in a radioligand binding assay using rat heart muscle .

HY-B1486R

Oxprenolol (hydrochloride) (Standard)	Adrenergic Receptor	Cardiovascular Disease
Oxprenolol (hydrochloride) (Standard) is the analytical standard of Oxprenolol (hydrochloride). This product is intended for research and analytical applications. Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle .

HY-124535

TGX-115	PI3K	Cardiovascular Disease
TGX-115 is a cytopermeable and potent PI3-K isomer p110β/p110δ inhibitor (p110β IC₅₀ value of 0.13 μM, p110δ IC₅₀ value of 0.63 μM).TGX-115 is an enzyme that regulates platelet adhesion process and inhibits phosphoinosine 3-kinase. TGX-115 can be used in the study of cardiovascular diseases such as coronary artery occlusion, stroke, acute coronary syndrome, acute myocardial infarction, restenosis, arteriosclerosis and unstable angina .

HY-17503B

Metoprolol tartrate Maximum Cited Publications 13 Publications Verification	Adrenergic Receptor Apoptosis	Infection Cardiovascular Disease Endocrinology Cancer
Metoprolol tartrate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol tartrate shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-17503A

Metoprolol succinate Maximum Cited Publications 13 Publications Verification	Adrenergic Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Metoprolol succinate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol succinate shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-17503

Metoprolol Maximum Cited Publications 13 Publications Verification	Adrenergic Receptor Apoptosis	Infection Cardiovascular Disease Endocrinology Cancer
Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-17503C

Metoprolol fumarate CGP 2175C; Lopressor OROS	Adrenergic Receptor Apoptosis	Infection Cardiovascular Disease Endocrinology Cancer
Metoprolol fumarate (CGP 2175C) is an orally active, selective β1-adrenoceptor antagonist. Metoprolol fumarate shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-17503AR

Metoprolol succinate (Standard)	Adrenergic Receptor Apoptosis	Cardiovascular Disease Endocrinology Cancer
Metoprolol (succinate) (Standard) is the analytical standard of Metoprolol (succinate). This product is intended for research and analytical applications. Metoprolol succinate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol succinate shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-17503BR

Metoprolol tartrate (Standard)	Adrenergic Receptor Apoptosis	Infection Cardiovascular Disease Endocrinology Cancer
Metoprolol (tartrate) (Standard) is the analytical standard of Metoprolol (tartrate). This product is intended for research and analytical applications. Metoprolol tartrate is an orally active, selective β1-adrenoceptor antagonist. Metoprolol tartrate shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-17503R

Metoprolol (Standard)	Adrenergic Receptor Apoptosis	Infection Cardiovascular Disease Endocrinology Cancer
Metoprolol (Standard) is the analytical standard of Metoprolol. This product is intended for research and analytical applications. Metoprolol is an orally active, selective β1-adrenoceptor antagonist. Metoprolol shows anti-inflammation, antitumor and anti-angiogenic properties .

HY-160637

Lp-PLA2-IN-17	Phospholipase	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Lp-PLA2-IN-17 (Compound 39) is an inhibitor of Lp-PLA₂. Lp-PLA2-IN-17 can be used to study disorders involving the hydrolysis of oxidized lipids into two inflammatory substances with the participation of Lp-PLA₂ .

Cat. No.	Product Name

HY-L117

Calcium Channel Blocker Library	157 compounds
Calcium channel blockers (CCBs), also called calcium antagonists are compounds that slow the movement of calcium (Ca2+) through calcium channels into the cells of the heart and blood vessel walls. Calcium causes the heart and arteries to squeeze more strongly. By blocking calcium, calcium channel blockers allow blood vessels to relax and open. So calcium channel blockers are usually used to lower blood pressure, relieve chest pain (angina) and control an irregular heartbeat. MCE supplies a unique collection of 157 calcium channel blockers and antagonists, all of which have the identified inhibitory effect on calcium channel. MCE Calcium Channel Blocker Library is a useful tool for discovery of antihypertensive drugs and cardiovascular disease research.

Calcium Channel Blocker Library

157 compounds

Calcium channel blockers (CCBs), also called calcium antagonists are compounds that slow the movement of calcium (Ca2+) through calcium channels into the cells of the heart and blood vessel walls. Calcium causes the heart and arteries to squeeze more strongly. By blocking calcium, calcium channel blockers allow blood vessels to relax and open. So calcium channel blockers are usually used to lower blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

MCE supplies a unique collection of 157 calcium channel blockers and antagonists, all of which have the identified inhibitory effect on calcium channel. MCE Calcium Channel Blocker Library is a useful tool for discovery of antihypertensive drugs and cardiovascular disease research.

Cat. No.	Product Name	Category	Target	Chemical Structure