2. Autophagy Metabolic Enzyme/Protease Apoptosis
  3. Autophagy Endogenous Metabolite Apoptosis
  4. Isosorbide mononitrate

Isosorbide mononitrate  (Synonyms: Isosorbide-5-mononitrate)

Cat. No.: HY-B0642 Purity: 99.91%
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Isosorbide mononitrate (Isosorbide-5-mononitrate) is an orally active nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure. Isosorbide mononitrate increases the viability and proliferation of HUVECs by decreasing Apoptosis and elevated the expressions of vedf, kdrl, pdgfr in zebrafish embryos. Isosorbide mononitrate is promising for research of heart failure and coronary heart disease.

For research use only. We do not sell to patients.

Isosorbide mononitrate Chemical Structure

Isosorbide mononitrate Chemical Structure

CAS No. : 16051-77-7

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10 mM * 1 mL in DMSO
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Based on 4 publication(s) in Google Scholar

Other Forms of Isosorbide mononitrate:

Isosorbide mononitrate Related Antibodies

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Description

Isosorbide mononitrate (Isosorbide-5-mononitrate) is an orally active nitric acid compound used for angina pectoris by dilating blood vessels and lowering blood pressure. Isosorbide mononitrate increases the viability and proliferation of HUVECs by decreasing Apoptosis and elevated the expressions of vedf, kdrl, pdgfr in zebrafish embryos. Isosorbide mononitrate is promising for research of heart failure and coronary heart disease[1][2][3][4].

In Vitro

Isosorbide mononitrate (0.5-50 μM, 5 min) inhibited angiogenesis in the chick chorioallantoic membrane dose-dependently[3].
Isosorbide mononitrate (4 ng/mL-5 μg/mL, 24 h) increases HUVECS viability and proliferation and decreases HUVECS apoptosis[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Isosorbide mononitrate Related Antibodies

Cell Viability Assay[4]

Cell Line: HUVECs
Concentration: 4 ng/mL-5 μg/mL
Incubation Time: 24 h
Result: Increased cell viability in a dose-dependent manner in HUVECs.

Apoptosis Analysis[4]

Cell Line: HUVECs
Concentration: 5 μg/mL
Incubation Time: 24 h
Result: Decreased apoptosis in HUVECs.
In Vivo

Isosorbide mononitrate (200, 600 μg, i.p., daily for 14 days) inhibits angiogenesis, tumour growth and metastasis in mouse tumour model[3].
Isosorbide mononitrate (500 μg/mL, 24 h) up-regulates expressions of vegf-a, kdrl, and pdgfr in zebrafish embryos[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice implanted intramuscularly with LLC[3]
Dosage: 200, 600 μg
Administration: i.p., daily for 14 days
Result: Decreased in the size of the primary tumour and a reduction in the number and size of metastatic foci in the mouse lungs.
Clinical Trial
Molecular Weight

191.14

Formula

C6H9NO6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=[N+]([O-])O[C@H]1[C@](OC[C@@H]2O)([H])[C@]2([H])OC1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (523.18 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (261.59 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2318 mL 26.1590 mL 52.3179 mL
5 mM 1.0464 mL 5.2318 mL 10.4636 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (13.08 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (13.08 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 33.33 mg/mL (174.38 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.91%

SDS (570 KB)

COA (247 KB) LCMS (261 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 5.2318 mL 26.1590 mL 52.3179 mL 130.7949 mL
5 mM 1.0464 mL 5.2318 mL 10.4636 mL 26.1590 mL
10 mM 0.5232 mL 2.6159 mL 5.2318 mL 13.0795 mL
15 mM 0.3488 mL 1.7439 mL 3.4879 mL 8.7197 mL
20 mM 0.2616 mL 1.3079 mL 2.6159 mL 6.5397 mL
25 mM 0.2093 mL 1.0464 mL 2.0927 mL 5.2318 mL
30 mM 0.1744 mL 0.8720 mL 1.7439 mL 4.3598 mL
40 mM 0.1308 mL 0.6540 mL 1.3079 mL 3.2699 mL
50 mM 0.1046 mL 0.5232 mL 1.0464 mL 2.6159 mL
60 mM 0.0872 mL 0.4360 mL 0.8720 mL 2.1799 mL
80 mM 0.0654 mL 0.3270 mL 0.6540 mL 1.6349 mL
100 mM 0.0523 mL 0.2616 mL 0.5232 mL 1.3079 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Isosorbide mononitrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isosorbide mononitrate16051-77-7Isosorbide-5-mononitrateAutophagyEndogenous MetaboliteApoptosisorally activeangina pectorisdilating blood vesselsvedfkdrlpdgfrzebrafish embryosInhibitorinhibitorinhibit

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