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Results for "

folate antagonist

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-126806
    Pyrrofolic acid

    		Antibiotic Cancer
    Pyrrofolic acid is a folate antagonist with a low activity as a folate antagonist for Streptococcus faecalis .
    Pyrrofolic acid
  • HY-135101
    Methotrexate γ-Methyl Ester

    Methotrexate 5-methyl ester; γ-EMTX

    		 Others Others
    Methotrexate γ-Methyl Ester (Methotrexate 5-methyl ester) is an impurity of the folate antagonist Methotrexate (HY-14519) .
    Methotrexate γ-Methyl Ester
  • HY-123098
    Tetrahydromethotrexate

    		Antifolate Bacterial DNA/RNA Synthesis Cancer
    Tetrahydromethotrexate is a more potent folate antagonist than Methotrexate (HY-14519) in studies against certain bacteria (Streptococcus faecalis, Pediococcus erevisiae) and in animal models. Tetrahydromethotrexate is used in the research of cancer and autoimmune diseases .
    Tetrahydromethotrexate
  • HY-121256
    Chlorasquin

    		Thymidylate Synthase Antifolate Dihydrofolate reductase (DHFR) Others
    Chlorasquin inhibits thymidylate synthetase with an approximate Ki value of 4.9 μM. Chlorasquin is also a folate antagonist, testing the Methotrexate (HY-14519) effect. Chlorasquin binds tighter to dihydrofolate reductase at alkaline pH than does Methotrexate, which is promising for research of antipsoriatic agents .
    Chlorasquin
  • HY-106423A
    Mivobulin isethionate

    CI-980; NSC 613862 isethionate; (S)-(-)-NSC 613862 isethionate

    		 Antifolate Microtubule/Tubulin Cancer
    Mivobulin (isethionate) (CI-980) is an orally active, brain-penetrant and potent folate antagonist and a tubulin-binding mitotic inhibitor. Mivobulin (isethionate) accumulates rapidly in L1210 and CHO/K1 cells to levels many-fold higher than those in the extracellular medium and efflux is also quite rapid. Mivobulin (isethionate) is promising for research of cancers .
    Mivobulin isethionate

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