1. Apoptosis Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  2. Thymidylate Synthase Antifolate Dihydrofolate reductase (DHFR)
  3. Chlorasquin

Chlorasquin inhibits thymidylate synthetase with an approximate Ki value of 4.9 μM. Chlorasquin is also a folate antagonist, testing the Methotrexate (HY-14519) effect. Chlorasquin binds tighter to dihydrofolate reductase at alkaline pH than does Methotrexate, which is promising for research of antipsoriatic agents.

For research use only. We do not sell to patients.

Chlorasquin Chemical Structure

Chlorasquin Chemical Structure

CAS No. : 18921-73-8

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Description

Chlorasquin inhibits thymidylate synthetase with an approximate Ki value of 4.9 μM. Chlorasquin is also a folate antagonist, testing the Methotrexate (HY-14519) effect. Chlorasquin binds tighter to dihydrofolate reductase at alkaline pH than does Methotrexate, which is promising for research of antipsoriatic agents[1][2].

Molecular Weight

458.86

Formula

C20H19ClN6O5

CAS No.
SMILES

O=C(C[C@H](NC(C1=CC=C(C=C1)NCC2=C(C3=C(N=C(N=C3C=C2)N)N)Cl)=O)C(O)=O)O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Chlorasquin
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HY-121256
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