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Results for "

low acute toxicity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Akt (1) Antibiotic (2) Apoptosis (5) Bacterial (1) Biochemical Assay Reagents (1) Carbonic Anhydrase (1) CDK (1) COX (1) Cytochrome P450 (1) Estrogen Receptor/ERR (6) Fungal (1) HDAC (1) HIF/HIF Prolyl-Hydroxylase (1) HIV (1) IFNAR (2) Insecticide (1) Interleukin Related (2) Isotope-Labeled Compounds (4) Monoamine Oxidase (1) NF-κB (2) Parasite (2) PI3K (1) Reverse Transcriptase (1) STAT (1) TET Protein (1) TNF Receptor (2) URAT1 (1)
By Research Areas:	Cancer (8) Endocrinology (3) Infection (4) Inflammation/Immunology (6) Neurological Disease (1)
Oligonucleotides:	Release-retarding Agents (1)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: LDLR LOX-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-41570

3-Formylsalicylic acid	Estrogen Receptor/ERR	Cancer
3-Formylsalicylic acid is a noncompetitive estrone sulfatase inhibitor with an IC₅₀ value of 0.15 mM, a K_i value of 0.12 mM. 3-Formylsalicylic acid shows a low acute toxicity .

HY-120395

UC-514321	STAT Apoptosis TET Protein	Inflammation/Immunology Cancer
UC-514321, a structural analog of NSC370284 with higher activity, directly targets STAT3/5 and represses TET1 expression, but not TET2 or TET3. UC-514321 has the potential to treat acute myeloid leukemia (AML) both in vitro and in vivo, with low toxicity .

HY-B1812

Veratrole	Antibiotic Apoptosis NF-κB	Others
Veratrole is a key compound found widely in plants that attracts pollinators. Veratrole can be used as a safe fragrance ingredient with low acute and administration toxicity .

HY-103447

Zearalenone Maximum Cited Publications 7 Publications Verification Mycotoxin F2; Toxin F2	Estrogen Receptor/ERR	Others
Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .

HY-N6678

Zearalanone 1 Publications Verification	Estrogen Receptor/ERR	Endocrinology
Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system .

HY-152927

Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da)	Biochemical Assay Reagents	Others
Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) is a cosolvent for preparing SDDs of low-solubility agents. Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) exhibits no acute/subchronic/chronic toxicity in rats, with oral activity and LD₅₀ >2.5 g/kg .

HY-147841

HIV-1 inhibitor-41	HIV Reverse Transcriptase	Infection
HIV-1 inhibitor-41 (Compound B23) is an orally active non-nucleoside HIV-1 reverse transcriptase inhibitor with EC₅₀ values of 20.8 nM and 50 nM against HIV-1 WT and mutant E138K strain, respectively. HIV-1 inhibitor-41 shows low hERG, no apparent CYP enzymatic inhibition and no acute toxicity .

HY-138100

Hyalodendrin (+)-Hyalodendrin	Fungal	Infection
Hyalodendrin ((+)-Hyalodendrin) is a fungal growth inhibitor with inhibitory activity against wood decay fungi. Hyalodendrin has low phytotoxicity, with an acute toxicity (LD50) of 75 mg/kg in mice .

HY-120407

Looplure ENT-33266	Insecticide	Others
Looplure (ENT-33266) is an insect attractant with acute toxicity studies in different animal models showing activity at oral and dermal median lethal doses (LD50) and median lethal concentrations (LC50) for fish with some values, and low toxicity in most cases except for some cases.

HY-B1812S4

Veratrole-d2-1	Antibiotic NF-κB Apoptosis Isotope-Labeled Compounds	Others
Veratrole-d2-1 is the deuterium labeled Veratrole (HY-B1812). Veratrole is a key compound found widely in plants that attracts pollinators. Veratrole can be used as a safe fragrance ingredient with low acute and administration toxicity .

HY-103447S

(Rac)-Zearalenone-d6	Isotope-Labeled Compounds	Others
(Rac)-Zearalenone-d₆ is the deuterium labled Zearalenone (HY-103447). Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .

HY-103447R

Zearalenone (Standard) Mycotoxin F2(Standard); Toxin F2 (Standard)	Estrogen Receptor/ERR	Others
Zearalenone (Standard) is the analytical standard of Zearalenone. This product is intended for research and analytical applications. Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .

HY-146495

Antitubercular agent-19	Bacterial	Infection
Antitubercular agent-19 (Compound 1c) is an antitubercular agent. Antitubercular agent-19 shows excellent activity against MTB H37Rv and MDR-MTB strains (MIC: ＜0.016 µg/ml). Antitubercular agent-19 shows low cytotoxicity and relatively high acute lethal toxicity in BALB/c mice .

HY-N6678S

(Rac)-Zearalanone-d6	Isotope-Labeled Compounds Estrogen Receptor/ERR	Endocrinology
(Rac)-Zearalanone-d₆ is the racemate of Zearalanone. Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system[1][2].

HY-147925

hCAI/II-IN-4	Carbonic Anhydrase	Others
hCAI/II-IN-4 (compound 6d) is a potent dual hCA I/II inhibitor with K_i values of 16.95, 15.22 and 27.04 nM for hCA I, hCA II and hCA Ⅸ, respectively. hCAI/II-IN-4 has anti-hypoxia activities and low toxicity. hCAI/II-IN-4 can be used for acute mountain sickness (AMS) research .

HY-N6678R

Zearalanone (Standard)	Estrogen Receptor/ERR	Endocrinology
Zearalanone (Standard) is the analytical standard of Zearalanone. This product is intended for research and analytical applications. Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system .

HY-12445

Asnuciclib 2 Publications Verification CDKI-73; LS-007	CDK Apoptosis	Inflammation/Immunology Cancer
Asnuciclib (CDKI-73; LS-007) is an orally active and highly efficacious CDK9 inhibitor, with K_i values of 4 nM, 4 nM and 3 nM for CDK9, CDK1 and CDK2, respectively. Asnuciclib down-regulates the RNAPII phosphorylation. Asnuciclib is also a novel pharmacological inhibitor of Rab11 cargo delivery and innate immune secretion .

HY-124591

TC-2153	5-HT Receptor Monoamine Oxidase	Neurological Disease
TC-2153 is a selective inhibitor of striatal-enriched protein tyrosine phosphatase (STEP), with psychotropic activity and low acute toxicity. TC-2153 increases the expression of brain-derived neurotropic factor (BDNF) in the brain. And it decreases MAOA and 5-HT1A receptors mRNA level in midbrain. TC-2153 also inhibits 5-HT2A receptor-mediated signaling .

HY-103447S1

Zearalenone-13C18 Mycotoxin F2-¹³C₁₈; Toxin F2-¹³C₁₈	Isotope-Labeled Compounds	Others
Zearalenone- ¹³C₁₈ (Mycotoxin F2- ¹³C₁₈; Toxin F2- ¹³C₁₈) is the ¹³C labeled Zearalenone (HY-103447) . Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .

HY-107390A

AX-024 hydrochloride 1 Publications Verification	TNF Receptor Interleukin Related IFNAR	Inflammation/Immunology Cancer
AX-024 hydrochloride is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC₅₀ ~1 nM. AX-024 hydrochloride modulates cell signaling by targeting SH3 domains. AX-024 hydrochloride has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.

HY-107390

AX-024 1 Publications Verification	TNF Receptor Interleukin Related IFNAR	Inflammation/Immunology Cancer
AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC₅₀ ~1 nM. AX-024 modulates cell signaling by targeting SH3 domains. AX-024 has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.

HY-144332

PHD2/HDACs-IN-1	HDAC HIF/HIF Prolyl-Hydroxylase	Cancer
PHD2/HDACs-IN-1 is a potent PHD2/HDACs hybrid inhibitor (IC₅₀s of 1.15 μM, 19.75 μM, 26.60 μM and 15.98 μM for PHD2, HDAC1, HDAC2 and HDAC6, respectively). PHD2/HDACs-IN-1 is a low-toxicity renoprotective agent for research of cisplatin-induced acute kidney injury (AKI) .

HY-W762012

Octachlorodibenzo-p-dioxin OCDD	Cytochrome P450	Others
Octachlorodibenzo-p-dioxin (OCDD) is an environmental contaminant but is not acutely toxic. In rats, Octachlorodibenzo-p-dioxin (50 μg/kg i.v. or 50-5000 μg/kg p.o.) has a systemic elimination half-life of 3-5 months and accumulates and concentrates in the liver and adipose tissue after low-dose, repeated exposure. Repeated administration of octachlorodibenzo-p-dioxin causes increases in 7-ethoxyresorufin-O-deethylase (7-EROD) activity and total cytochrome P-450 levels .

HY-155997

Anti-inflammatory agent 56	COX	Inflammation/Immunology
Anti-inflammatory agent 56 (Compound 9) is a selective COX-2 inhibitor (IC₅₀: 0.54 μM). Anti-inflammatory agent 56 has anti-oxidant and anti-inflammatory effects. Anti-inflammatory agent 56 inhibits oxidative stress induced cell death. Anti-inflammatory agent 56 inhibits oxidative stress and neuroinflammation by inhibiting Keap1, COX-2 and iNOS. Anti-inflammatory agent 56 has low acute toxicity in mice (LD₅₀: 1000 mg/kg) .

HY-155732

NPD-2975	Parasite	Infection
NPD-2975 (compound 30) is an orally active antitrypanosomal agent, against Human African Trypanosomiasis (HAT). NPD-2975 has low toxicity potential against human MRC-5 lung fibroblasts, and acute mouse model of T. b. brucei infection. NPD-2975 shows acceptable metabolic stability, inhibits T. b. brucei with IC₅₀0 of 70 nM in vitro. NPD-2975 also inhibits CYP enzymes resulted in IC₅₀ values of 0.16 and 0.42 μM against CYP1A2 and CYP2C19, respectively .

HY-121067

Carbarsone	Parasite	Cancer
Carbarsone, also known as p-ureidobenzenearsonic acid, is historically used as an amebicide in human and veterinary medicine and extensively employed in poultry and swine feed, often in combination with antibiotics to prevent conditions like blackhead in turkeys. It exhibits relatively low acute toxicity, prompting investigations into its safety for food additives under the Federal Food, Drug, and Cosmetic Act. Studies aimed at assessing its potential carcinogenicity in laboratory animals have shown negative evidence similar to other arsanilic acid derivatives, suggesting minimal risk under chronic ingestion conditions. Metabolically, carbarsone is converted to arsanilic acid, which has been observed in preliminary studies involving dogs at high doses .

HY-121672

PI3K-IN-7	PI3K Akt Apoptosis	Cancer
PI3K-IN-7 (Compound C96) is a PI3K inhibitor. PI3K-IN-7 inhibits phosphorylation of AKT and the activation of an AKT downstream protein. PI3K-IN-7 induces apoptosis of the tumor cells. PI3K-IN-7 has low toxicity for normal cells. PI3K-IN-7 can be used for research of acute and chronic leukemia, multiple myeloma, lymphoma .

HY-143906

URAT1 inhibitor 2	URAT1	Inflammation/Immunology
URAT1 inhibitor 2 is an orally active and potent URAT1 and CYP isozyme inhibitor, with IC₅₀ values of 1.36 μM, 16.97 μM, 5.22 μM for URAT1-mediated ¹⁴C-UA uptake, CYP1A2 and CYP2C9, respectively. URAT1 inhibitor 2 is a promising agent candidate in the study of hyperuricemia and gout .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1812

Veratrole	Structural Classification Natural Products Glycine soya Classification of Application Fields Source classification Other Diseases Cyamopsis tetragonoloba (L.) Taub. Plants Compositae Disease Research Fields	Antibiotic Apoptosis NF-κB
Veratrole is a key compound found widely in plants that attracts pollinators. Veratrole can be used as a safe fragrance ingredient with low acute and administration toxicity .

HY-103447

Zearalenone 5+ Cited Publications Mycotoxin F2; Toxin F2	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Phenols Polyphenols Disease Research Fields	Estrogen Receptor/ERR
Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .

HY-N6678

Zearalanone 1 Publications Verification	Structural Classification Classification of Application Fields Source classification Antibacterial Disease Research Microorganisms Macrolide Antibiotics Antibiotics Phenols Polyphenols Anticancer Disease Research Fields Endocrinology	Estrogen Receptor/ERR
Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system .

HY-103447R

Zearalenone (Standard) Mycotoxin F2(Standard); Toxin F2 (Standard)	Microorganisms Classification of Application Fields Source classification Other Diseases Disease Research Fields	Estrogen Receptor/ERR
Zearalenone (Standard) is the analytical standard of Zearalenone. This product is intended for research and analytical applications. Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .

HY-138100

Hyalodendrin (+)-Hyalodendrin	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Fungal
Hyalodendrin ((+)-Hyalodendrin) is a fungal growth inhibitor with inhibitory activity against wood decay fungi. Hyalodendrin has low phytotoxicity, with an acute toxicity (LD50) of 75 mg/kg in mice .

HY-N6678R

Zearalanone (Standard)	Structural Classification Microorganisms Macrolide Antibiotics Antibiotics Source classification Phenols Polyphenols Antibacterial Disease Research Anticancer	Estrogen Receptor/ERR
Zearalanone (Standard) is the analytical standard of Zearalanone. This product is intended for research and analytical applications. Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system .

Cat. No.	Product Name	Chemical Structure

HY-103447S1

Zearalenone-13C18
Zearalenone- ¹³C₁₈ (Mycotoxin F2- ¹³C₁₈; Toxin F2- ¹³C₁₈) is the ¹³C labeled Zearalenone (HY-103447) . Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .

Zearalenone-13C18

Zearalenone- ¹³C₁₈ (Mycotoxin F2- ¹³C₁₈; Toxin F2- ¹³C₁₈) is the ¹³C labeled Zearalenone (HY-103447) . Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .

HY-B1812S4

Veratrole-d2-1
Veratrole-d2-1 is the deuterium labeled Veratrole (HY-B1812). Veratrole is a key compound found widely in plants that attracts pollinators. Veratrole can be used as a safe fragrance ingredient with low acute and administration toxicity .

HY-103447S

(Rac)-Zearalenone-d6
(Rac)-Zearalenone-d₆ is the deuterium labled Zearalenone (HY-103447). Zearalenone is a mycotoxin produced mainly by fungi belonging to the genus Fusarium in foods and feeds. Possess oestrogenic activity in pigs, cattle and sheep, with low acute toxicity. Causes precocious development of mammae and other estrogenic effects in young gilts .

HY-N6678S

(Rac)-Zearalanone-d6
(Rac)-Zearalanone-d₆ is the racemate of Zearalanone. Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system[1][2].

(Rac)-Zearalanone-d6

(Rac)-Zearalanone-d₆ is the racemate of Zearalanone. Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system[1][2].

Cat. No.	Product Name		Classification

HY-152927

Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da)		Release-retarding Agents
Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) is a cosolvent for preparing SDDs of low-solubility agents. Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) exhibits no acute/subchronic/chronic toxicity in rats, with oral activity and LD₅₀ >2.5 g/kg .

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