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permeation

" in MedChemExpress (MCE) Product Catalog:

33

Inhibitors & Agonists

1

Screening Libraries

4

Fluorescent Dye

2

Biochemical Assay Reagents

7

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1

Inhibitory Antibodies

5

Natural
Products

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N7132
    Menthyl acetate

    L-Menthyl acetate; (-)-Menthyl acetate

    		 Others Others
    ​Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol. ​Menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation .
    Menthyl acetate
  • HY-W141881
    N-Lauroylsarcosine

    		Biochemical Assay Reagents Others
    N-lauroylsarcosine is an anionic surfactant, and can be used as a permeation enhancer. The mixture of N-lauroylsarcosine in 25-50% ethanol acts synergistically to increase skin permeability, which may be useful for transdermal drug delivery research .
    N-Lauroylsarcosine
  • HY-141661
    Aβ/tau aggregation-IN-1

    		Amyloid-β Neurological Disease
    Aβ/tau aggregation-IN-1 is a potent Aβ1-42 β-sheets formation and tau aggregation inhibitor. The KD values of Aβ/tau aggregation-IN-1 with Aβ1-42 and tau are 160 μM and 337 μM, respectively. Aβ/tau aggregation-IN-1 can permeate the blood-brain barrier .
    Aβ/tau aggregation-IN-1
  • HY-114299
    Salcaprozate sodium
    1 Publications Verification

    SNAC

    		 Others Others
    Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation .
    Salcaprozate sodium
  • HY-138560
    Cross-linked dextran G 50
    1 Publications Verification

    		 Biochemical Assay Reagents Others
    Cross-linked dextran G 50 is a gel filtration medium. Cross-linked dextran G 50 can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da) .
    Cross-linked dextran G 50
  • HY-W040996
    2-Octyldodecanol

    		Others Others
    2-Octyldodecanol can enhance the skin permeation of formoterol fumarate (HY-B0010) .
    2-Octyldodecanol
  • HY-N7132R
    Menthyl acetate (Standard)

    		Others Others
    Menthyl acetate (Standard) is the analytical standard of Menthyl acetate. This product is intended for research and analytical applications. ?Menthyl acetate (L-Menthyl acetate) is a derivative of L-menthol. ?Menthyl acetate is effective to enhance 5-aminolevulinic acid (ALA) skin permeation .
    Menthyl acetate (Standard)
  • HY-114299R
    Salcaprozate sodium (Standard)

    		Others Others
    Salcaprozate (sodium) (Standard) is the analytical standard of Salcaprozate (sodium). This product is intended for research and analytical applications. Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation .
    Salcaprozate sodium (Standard)
  • HY-151389
    BChE-IN-14

    		Cholinesterase (ChE) Neurological Disease
    BChE-IN-14 (compound 19c) is a selective butyrylcholinesterase (BChE) inhibitor with IC50s of 0.23 and 0.011 μM for eqBChE and hBChE, respectively. BChE-IN-14 shows good blood brain barrier permeation and primary cell safety. BChE-IN-14 is able to restore cognitive impairment in vivo, it can be used for the research of Alzheimer’s disease .
    BChE-IN-14
  • HY-B2119
    Sodium tauroglycocholate

    Tauroglycocholic acid sodium salt

    		 Biochemical Assay Reagents Endocrinology
    Sodium tauroglycocholate is an inhibitor of the biliary acid transporting system of the hepatocyte and also a surfactant used as a chemical permeation enhancer.
    Sodium tauroglycocholate
  • HY-11054
    TH-237A

    meso-GS 164

    		 Others Neurological Disease
    TH-237A(meso-GS 164) is a novel neuroprotective agent exhibiting favorable permeation across the blood brain barrier.
    TH-237A
  • HY-N2197
    Hirsuteine

    		nAChR Neurological Disease
    Hirsuteine is an indole alkaloid extracted from Uncaria rhynchophylla. Hirsuteine non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes .
    Hirsuteine
  • HY-P10325
    Kalata B7

    		Vasopressin Receptor Oxytocin Receptor Cardiovascular Disease
    Kalata B7 is a cyclotide that can be isolated from Oldenlandia affinis DC (Rubiaceae) and possesses membrane-permeating capabilities. Kalata B7 is also a partial agonist of oxytocin and vasopressin V1a receptors .
    Kalata B7
  • HY-W598230A
    m-PEG-NH2 hydrochloride (MW 2000)

    		Biochemical Assay Reagents Others
    m-PEG-NH2 (hydrochloride) (MW 2000) is a barrier permeation compound involved in the preparation of hybrid gels with adsorption and size exclusion chromatography (AdSEC) properties. m-PEG-NH2 helps AdSEC gels separate from complex biological mixtures such as blood, urine, sweat, and tears.
    m-PEG-NH2 hydrochloride (MW 2000)
  • HY-D1783
    MitoTracker Deep Red FM
    1 Publications Verification

    		 Fluorescent Dye Others
    MitoTracker Deep Red FM fluorescent dye that selectively accumulates in the mitochondrial matrix. MitoTracker Deep Red FM covalently binds mitochondrial proteins by reacting with free mercaptan of cysteine residues, allowing staining of mitochondrial membrane potential independent of membrane potential. Excitation/emission wavelength 644/665 nm . Storage: Keep away from light.
    MitoTracker Deep Red FM
  • HY-N7539
    Cognac oil

    		Others Metabolic Disease
    Cognac oil, mainly found in wine lees, has unique fatty acid profiles, including Palmitic acid (59.26%), Linoleic acid (11.92%), Myristic acid (8.97%), Oleic acid (8.3%) and other fatty acids. Cognac oil leads to a general increase in the permeation of R6G (Rhodamine 6G) across all the membranes .
    Cognac oil
  • HY-144604
    FPR2 agonist 2

    		Formyl Peptide Receptor (FPR) Infection Neurological Disease
    FPR2 agonist 2 is a potent and permeates the blood?brain barrier FPR2 agonist with an EC50 of 0.13 μM, 1.1 μM for FPR2 and FPR1, respectively. FPR2 agonist 2 inhibits the production of pro-inflammatory cytokines, counterbalances the changes in mitochondrial function, and inhibits caspase-3 activity .
    FPR2 agonist 2
  • HY-P4210
    Sulanemadlin

    ALRN-6924; MP-4897

    		 MDM-2/p53 Cancer
    Sulanemadlin (ALRN-6924) is a potent and cell-permeating p53-based peptidomimetic macrocycles. Sulanemadlin is a inhibitor of the p53-MDM2, p53-MDMX, or both p53 and MDM2 and MDMX protein-protein interactions. Sulanemadlin can be used for cancers research .
    Sulanemadlin
  • HY-114299S
    Salcaprozate-d4 sodium

    SNAC-d4 sodium

    		 Isotope-Labeled Compounds Others
    Salcaprozate-d4 (sodium) is a deuterated labeled Salcaprozate (sodium) . Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation .
    Salcaprozate-d4 sodium
  • HY-119151
    GS-9191

    		Apoptosis HPV DNA/RNA Synthesis Infection
    GS-9191 is the prodrug of the nucleotide analog PMEG. GS-9191 is a topical agent to permeate skin and be metabolized to the active nucleoside triphosphate analog in the epithelial layer. GS-9191 inhibits NA synthesis, arrests cell in S phase, and induces cell apoptosis. GS-9191 can be used for research of human papillomaviruses (HPV) infection .
    GS-9191
  • HY-D1684
    DCDAPH

    		Amyloid-β Neurological Disease
    DCDAPH (Compound 2c) is a novel smart NIRF probe for detection of β-amyloid (Aβ) plaques (λex/λem=597/665 nm in PBS). DCDAPH shows high affinity for Aβ aggregates (Ki=37 nM, Kd=27 nM). DCDAPH shows good blood brain barrier permeation and can meet most of the requirements for the detection of Aβ plaques both in vitro and in vivo .
    DCDAPH
  • HY-D0041
    Calcein-AM
    Maximum Cited Publications
    47 Publications Verification

    Calcein acetoxymethyl ester

    		 Fluorescent Dye Cancer
    Calcein AM, has cell membrane permeability and can easily enter the cell. Calcein AM has no fluorescence and is hydrolyzed by endogenous esterase in the cell to produce polar molecule Calcein (Calcein), which has strong negative charge and cannot permeate the cell membrane. Calcein can emit strong green fluorescence, so it is often used with Propidium Iodide for cell viability/virulence detection, excitation/emission wavelength: 494/515 nm .
    Calcein-AM
  • HY-117843
    Ppc-1

    		Mitochondrial Metabolism Interleukin Related Bacterial Infection Metabolic Disease Inflammation/Immunology
    Ppc-1 is a mitochondrial uncoupler. Ppc-1 enhances mitochondrial oxygen consumption without adverse effects on ATP production. Ppc-1 is a cell-permeate interleukin-2 (IL-2) inhibitor. Ppc-1 inhibits the Gram-negative periodontopathogen Porphyromonas gingivalis. Ppc-1 has anti-obesity, antibacterial and anti-inflammatory activities .
    Ppc-1
  • HY-D1585
    BODIPY TR methyl ester

    		Fluorescent Dye Others
    BODIPY TR methyl ester is a lipophilic GFP Counterstain. BODIPY TR methyl ester dye readily permeates cell membranes and localizes in endomembranous organelles but not localize strongly in plasma membranes. BODIPY TR methyl ester is an excellent red fluorescent vital dye (Ex=568 nm, Em=625 nm), can be used to reveal the location and shapes of cell nuclei, the shapes of cells within embryonic tissues, as well as the bound aries of organ-forming tissues within the whole embryo .
    BODIPY TR methyl ester
  • HY-120536
    HPi1

    		Bacterial Infection
    HPi1 is a potent, selective and orally active antimicrobial against Helicobacter pylori with an IC50 of 0.24 μM and an MIC of 0.08-0.16 μg/mL. HPi1 is inactive against other bacteria, including the gut commensals Lactobacillus casei, Lactobacillus reuteri, and Bifidobacterium longum .
    HPi1
  • HY-P10618
    BTM-P1

    		Bacterial Infection
    BTM-P1 is a polycationic peptide that exhibits antibacterial activity against both Gram-positive and Gram-negative bacteria. BTM-P1 can form ion-permeable channels in the inner mitochondrial membrane to interfere with mitochondrial energy processes .
    BTM-P1
  • HY-13750
    Ebselen
    10+ Cited Publications

    SPI-1005; PZ-51; CCG-39161

    		 Calcium Channel Virus Protease HIV Phosphatase Infection Neurological Disease Inflammation/Immunology Cancer
    Ebselen (SPI-1005), a glutathione peroxidase mimetic, is a potent voltage-dependent calcium channel (VDCC) blocker . Ebselen potently inhibits M pro (IC50=0.67 μM) and COVID-19 virus (EC50=4.67 μM) .Ebselen is an inhibitor of HIV-1 capsid CTD dimerization. Ebselen, an organoselenium compound, can permeate the blood-brain barrier and has anti-inflammatory, antioxidant and anticancer activity .
    Ebselen
  • HY-147659
    AChE/BChE/BACE-1-IN-2

    		Cholinesterase (ChE) Beta-secretase ROS Kinase Neurological Disease
    AChE/BChE/BACE-1-IN-2 (Compound 4o) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.069, 0.127 and 0.097 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-2 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-2 has remarkable antioxidant potential .
    AChE/BChE/BACE-1-IN-2
  • HY-147658
    AChE/BChE/BACE-1-IN-1

    		Cholinesterase (ChE) Beta-secretase ROS Kinase Neurological Disease
    AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential .
    AChE/BChE/BACE-1-IN-1
  • HY-P99849
    Depatuxizumab

    ABT-806

    		 EGFR Cancer
    Depatuxizumab is a brain-penetrant and humanized tumor-specific anti EGFR monoclonal antibody. Depatuxizumab inhibits the growth of xenograft models of mutant EGFRvIII and wild-type EGFR. Depatuxizumab can be used for research on cancer .
    Depatuxizumab
  • HY-D0150
    Thiazole Orange
    1 Publications Verification

    		 Fluorescent Dye Others
    Thiazole Orange is an asymmetric anthocyanin dye that can be coupled with oligonucleotides (ONs) to prepare fluorescent hybridization probes. Thiazole Orange has been widely used in biomolecular detection and staining of DNA/ RNA in gels and can be used for reticulocyte analysis. Thiazole orange generates a significant fluorescence enhancement and high quantum yield when it binds with nucleic acids, especially RNA. Thiazole orange can permeate living cell membranes. Thiazole orange can use UV light for detection, but can also be detected with blue light. The excitation and emission of Thiazole orange are λex = 510 nm (488 nm and 470 nm also show strong excitation) and λem = 527 nm, respectively .
    Thiazole Orange
  • HY-146313
    BChE-IN-7

    		Cholinesterase (ChE) Neurological Disease
    BChE-IN-7 (compound 13) is a potent, selective, BBB-penetrated and reversible AChE and BChE inhibitor, with an IC50 of 0.06 μM (BChE). BChE-IN-7 can protect neuronal-like cells from toxic Aβ-species .
    BChE-IN-7
  • HY-118097
    GW0072

    		Others Cancer
    Targeted molecular dynamics simulations of the entry of GW0072, a macromolecular ligand with flexible ionic properties, into the ligand-binding domain of the nuclear receptor PPARc were performed. Starting from the apo-form, where the ligand is located outside the receptor, the simulation ultimately locks the ligand into the binding pocket, yielding a structure very close to the holo-form. The results show that the entry process is mainly guided by hydrophobic interactions, and that the entry and exit pathways are very similar. We suggest that the TMD approach may be useful in distinguishing ligands generated by in silico docking. To address the question of the ligand entry process, we report targeted molecular dynamics (TMD) simulations of the binding of the GW0072 ligand to the ligand-binding domain (LBD) of the peroxisome proliferator-activated receptor gamma (PPARc). PPARc is a member of the nuclear receptor superfamily and an important agent target for many diseases. We chose to study this complex because (i) GW0072 is a large ionic, highly flexible ligand that includes aliphatic chains and polar groups, and (ii) previous simulations have defined a possible escape pathway for this ligand. Starting from the apo-form of the receptor (PDB.ID 1PRG, chain A), with the ligand located outside, TMD simulations converged on a holo-form complex that is close to the target structure (PDB.ID 4PRG, chain A), defining a permeation pathway into the binding pocket that is very similar to the escape pathway. However, during the entry of GW0072 into the receptor (Fig. 5), the helices are very mobile, and once the ligand is placed in the pocket, AF-2 becomes more rigid during the remainder of the simulation (Fig. S1 in the Supplementary Materials). This finding is in good agreement with the observations of Oberfield et al. [12], suggesting that despite the absence of direct interaction with the ligand, the presence of the ligand in the binding site stabilizes an intermediate conformation of AF-2, which may be responsible for the property of GW0072 as a partial agonist.
    GW0072

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