2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Cholinesterase (ChE) Beta-secretase ROS Kinase
  4. AChE/BChE/BACE-1-IN-1

AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential.

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AChE/BChE/BACE-1-IN-1 Chemical Structure

AChE/BChE/BACE-1-IN-1 Chemical Structure

CAS No. : 1321361-13-0

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AChE/BChE/BACE-1-IN-1 Related Antibodies

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Description

AChE/BChE/BACE-1-IN-1 (Compound 4k) is an orally active inhibitor of AChE, BChE, and BACE-1 with IC50 values of 0.058, 0.082 and 0.115 μM against hAChE, hBChE and hBACE-1, respectively. AChE/BChE/BACE-1-IN-1 shows considerable PAS-AChE binding capability, excellent brain permeation, potential disassembly of Aβ aggregates, and neuroprotective activity against Aβ-induced stress. AChE/BChE/BACE-1-IN-1 has remarkable antioxidant potential[1].

IC50 & Target

IC50: 0.058 μM (hAChE), 0.082 μM (hBChE), 0.115 μM (hBACE-1)[1]
In Vivo

AChE/BChE/BACE-1-IN-1 (Compound 4k) (0-10 mg/kg; p.o.) ameliorates cognitive dysfunction against the scopolamine-induced amnesia model in the Y-maze test[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

350.38

Formula

C19H21F3N2O
CAS No.
SMILES

FC(F)(OC1=CC=C(C=C1)CNC2CCN(C2)CC3=CC=CC=C3)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AChE/BChE/BACE-1-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AChE/BChE/BACE-1-IN-11321361-13-0Cholinesterase (ChE)Beta-secretaseROS KinaseBACEβ-SecretaseAlzheimer’s diseaseacetylcholinesterasebutyrylcholinesteraseAβ aggregationneuroprotective activityInhibitorinhibitorinhibit

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