2. Apoptosis Anti-infection Cell Cycle/DNA Damage
  3. Apoptosis HPV DNA/RNA Synthesis
  4. GS-9191

GS-9191 is the prodrug of the nucleotide analog PMEG. GS-9191 is a topical agent to permeate skin and be metabolized to the active nucleoside triphosphate analog in the epithelial layer. GS-9191 inhibits NA synthesis, arrests cell in S phase, and induces cell apoptosis. GS-9191 can be used for research of human papillomaviruses (HPV) infection.

For research use only. We do not sell to patients.

GS-9191 Chemical Structure

GS-9191 Chemical Structure

CAS No. : 859209-84-0

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Based on 1 publication(s) in Google Scholar

GS-9191 Related Antibodies

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Description

GS-9191 is the prodrug of the nucleotide analog PMEG. GS-9191 is a topical agent to permeate skin and be metabolized to the active nucleoside triphosphate analog in the epithelial layer. GS-9191 inhibits NA synthesis, arrests cell in S phase, and induces cell apoptosis. GS-9191 can be used for research of human papillomaviruses (HPV) infection[1].

Cellular Effect
Cell Line Type Value Description References
Ca-Ski EC50
2.03 nM
Compound: GS-9191
Antiproliferative activity against HPV-transformed human CaSki cells after 7 days by SRB assay
Antiproliferative activity against HPV-transformed human CaSki cells after 7 days by SRB assay
[PMID: 19398642]
HeLa EC50
0.71 nM
Compound: GS-9191
Antiproliferative activity against HPV-transformed human HeLa cells after 7 days by SRB assay
Antiproliferative activity against HPV-transformed human HeLa cells after 7 days by SRB assay
[PMID: 19398642]
HT-3 EC50
5.42 nM
Compound: GS-9191
Antiproliferative activity against HPV-non-transformed human HT3 cells after 7 days by SRB assay
Antiproliferative activity against HPV-non-transformed human HT3 cells after 7 days by SRB assay
[PMID: 19398642]
ME-180 EC50
1.83 nM
Compound: GS-9191
Antiproliferative activity against HPV-transformed human ME180 cells after 7 days by SRB assay
Antiproliferative activity against HPV-transformed human ME180 cells after 7 days by SRB assay
[PMID: 19398642]
SCC-4 EC50
5.03 nM
Compound: GS-9191
Antiproliferative activity against HPV-non-transformed human SCC4 cells after 7 days by SRB assay
Antiproliferative activity against HPV-non-transformed human SCC4 cells after 7 days by SRB assay
[PMID: 19398642]
SCC-9 EC50
15.3 nM
Compound: GS-9191
Antiproliferative activity against HPV-non-transformed human SCC9 cells after 7 days by SRB assay
Antiproliferative activity against HPV-non-transformed human SCC9 cells after 7 days by SRB assay
[PMID: 19398642]
SiHa EC50
> 74 nM
Compound: GS-9191
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 3 hrs by ELISA
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 3 hrs by ELISA
[PMID: 19398642]
SiHa EC50
0.03 nM
Compound: GS-9191
Antiproliferative activity against HPV-transformed human SiHa cells after 7 days by SRB assay
Antiproliferative activity against HPV-transformed human SiHa cells after 7 days by SRB assay
[PMID: 19398642]
SiHa EC50
1 nM
Compound: GS-9191
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 6 to 9 hrs by ELISA
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 6 to 9 hrs by ELISA
[PMID: 19398642]
SiHa EC50
1.8 nM
Compound: GS-9191
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 24 to 27 hrs by ELISA
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 24 to 27 hrs by ELISA
[PMID: 19398642]
SiHa EC50
11.5 nM
Compound: GS-9191
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 72 to 75 hrs by ELISA
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 72 to 75 hrs by ELISA
[PMID: 19398642]
SiHa EC50
7.8 nM
Compound: GS-9191
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 3 to 6 hrs by ELISA
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 3 to 6 hrs by ELISA
[PMID: 19398642]
SiHa EC50
7.9 nM
Compound: GS-9191
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 48 to 51 hrs by ELISA
Inhibition of DNA synthesis in HPV-transformed human SiHa cells assessed as decrease in BrdU incorporation after 48 to 51 hrs by ELISA
[PMID: 19398642]
Molecular Weight

734.82

Formula

C37H51N8O6P
CAS No.
SMILES

CC(C)COC([C@H](CC1=CC=CC=C1)NP(COCCN2C3=NC(N)=NC(NC4CC4)=C3N=C2)(N[C@H](C(OCC(C)C)=O)CC5=CC=CC=C5)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GS-9191 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GS-9191859209-84-0GS9191GS 9191ApoptosisHPVDNA/RNA SynthesisHuman papillomavirusnucleotide analogPMEGDNA synthesisInhibitorinhibitorinhibit

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