2. Immunology/Inflammation
  3. Interleukin Related
  4. 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole

2-(Chloromethyl)-4-(4-nitrophenyl)thiazole 

Cat. No.: HY-W040311 Purity: ≥98.0%
SDS COA Handling Instructions

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2-(Chloromethyl)-4-(4-nitrophenyl)thiazole has anti-cancer activity in hepatocellular carcinoma (HCC) by repression of M2 polarization of Tumor-associated macrophages (TAMs). 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole can be isolated from Astragalus propinquus Schischk.

For research use only. We do not sell to patients.

2-(Chloromethyl)-4-(4-nitrophenyl)thiazole Chemical Structure

2-(Chloromethyl)-4-(4-nitrophenyl)thiazole Chemical Structure

CAS No. : 89250-26-0

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2-(Chloromethyl)-4-(4-nitrophenyl)thiazole Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

2-(Chloromethyl)-4-(4-nitrophenyl)thiazole has anti-cancer activity in hepatocellular carcinoma (HCC) by repression of M2 polarization of Tumor-associated macrophages (TAMs). 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole can be isolated from Astragalus propinquus Schischk[1].

In Vitro

2-(Chloromethyl)-4-(4-nitrophenyl)thiazole (Compound APS) (16 mg/mL) enhances the expression of M1 macrophage markers (iNOS, IL-1β and TNF-α) and M1 macrophage proportions, while reducing the expression of M2 macrophage markers (IL-10, Arg-1) and M2 macrophage proportions in tumour-associated macrophages (TAMs)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-(Chloromethyl)-4-(4-nitrophenyl)thiazole Related Antibodies
Molecular Weight

254.69

Formula

C10H7ClN2O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=[N+](C1=CC=C(C2=CSC(CCl)=N2)C=C1)[O-]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (247 KB)

Handling Instructions (2659 KB)
References
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2-(Chloromethyl)-4-(4-nitrophenyl)thiazole Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-(Chloromethyl)-4-(4-nitrophenyl)thiazole89250-26-0Interleukin RelatedILAnti-cancerTumorHCCTAMhepatocellular carcinomaM2 polarizationInhibitorinhibitorinhibit

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