2. Academic Validation
  3. Natural polysaccharides as promising reno-protective agents for the treatment of various kidney injury

Natural polysaccharides as promising reno-protective agents for the treatment of various kidney injury

  • Pharmacol Res. 2024 Jul 14:207:107301. doi: 10.1016/j.phrs.2024.107301.
Yufei Ye 1,  Maoting Li 2,  Wei Chen 3,  Hongrui Wang 4,  Xuhui He 4,  Nanmei Liu 5,  Zhiyong Guo 6,  Chengjian Zheng 7
Affiliations

Affiliations

  • 1 Department of Chinese Medicine Authentication, Faculty of Pharmacy, Second Military Medical University/Naval Medical University, 325 Guohe Road, Shanghai 200433, China; Department of Nephrology, Changhai Hospital, Second Military Medical University/Naval Medical University, 168 Changhai Road, Shanghai 200433, China.
  • 2 Department of Chinese Medicine Authentication, Faculty of Pharmacy, Second Military Medical University/Naval Medical University, 325 Guohe Road, Shanghai 200433, China; Department of Nephrology, Naval Medical Center of PLA, Second Military Medical University/Naval Medical University, 338 West Huaihai Road, Shanghai 200052, China.
  • 3 Department of Nephrology, Changhai Hospital, Second Military Medical University/Naval Medical University, 168 Changhai Road, Shanghai 200433, China.
  • 4 Department of Chinese Medicine Authentication, Faculty of Pharmacy, Second Military Medical University/Naval Medical University, 325 Guohe Road, Shanghai 200433, China.
  • 5 Department of Nephrology, Naval Medical Center of PLA, Second Military Medical University/Naval Medical University, 338 West Huaihai Road, Shanghai 200052, China. Electronic address: 13585996275@163.com.
  • 6 Department of Nephrology, Changhai Hospital, Second Military Medical University/Naval Medical University, 168 Changhai Road, Shanghai 200433, China. Electronic address: drguozhiyong@163.com.
  • 7 Department of Chinese Medicine Authentication, Faculty of Pharmacy, Second Military Medical University/Naval Medical University, 325 Guohe Road, Shanghai 200433, China. Electronic address: cjzheng1984@126.com.
PMID: 39009291 DOI: 10.1016/j.phrs.2024.107301
Abstract

Renal injury, a prevalent clinical outcome with multifactorial etiology, imposes a substantial burden on society. Currently, there remains a lack of effective management and treatments. Extensive research has emphasized the diverse biological effects of natural Polysaccharides, which exhibit promising potential for mitigating renal damage. This review commences with the pathogenesis of four common renal diseases and the shared mechanisms underlying renal injury. The renoprotective roles of Polysaccharides in vivo and in vitro are summarized in the following five aspects: anti-oxidative stress effects, anti-apoptotic effects, anti-inflammatory effects, anti-fibrotic effects, and gut modulatory effects. Furthermore, we explore the structure-activity relationship and bioavailability of Polysaccharides in relation to renal injury, as well as investigate their utility as biomaterials for alleviating renal injury. The clinical experiments of Polysaccharides applied to patients with chronic kidney disease are also reviewed. Broadly, this review provides a comprehensive perspective on the research direction of natural Polysaccharides in the context of renal injury, with the primary aim to serve as a reference for the clinical development of Polysaccharides as pharmaceuticals and prebiotics for the treatment of kidney diseases.

Keywords

Apoptosis; Fibrosis; Gut–kidney axis; Natural polysaccharides; Oxidative stress; Renal injury.

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