2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. MMP

MMP

Matrix metalloproteinases

MMP

Related Products

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MMPs (Matrix metalloproteinases) are zinc-dependent endopeptidases. The MMPs belong to a larger family of proteases known as the metzincin superfamily. MMPs are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands and chemokine/cytokine inactivation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration, differentiation, angiogenesis, apoptosis, and host defense. MMP-2 and MMP-9 are thought to be important in metastasis. MMP-1 is thought to be important in rheumatoid arthritis and osteoarthritis. Recent data suggests active role of MMPs in the pathogenesis of Aortic Aneurysm. Excess MMPs degrade the structural proteins of the aortic wall. Disregulation of the balance between MMPs and TIMPs is also a characteristic of acute and chronic cardiovascular diseases.

MMP Isoform Specific Products:

MMP Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N2388R
    Auraptene (Standard)
    		Inhibitor
    Auraptene (Standard) is the analytical standard of Auraptene. This product is intended for research and analytical applications. Auraptene is an orally active geranyloxycoumarin that can be isolated from plants in the Brassicaceae family, antibacterial, anti-pathogen, antioxidant, anti-tumor, and neuroprotective effects. Auraptene plays an important role in the treatment of various chronic diseases such as hypertension and cystic fibrosis.
    Auraptene (Standard)
  • HY-169062
    RJF02215
    		Inhibitor
    RJF02215 is an MMP-9 inhibitor. RJF02215 has growth-inhibitory activity on the ovarian cancer SKOV3 cell line. RJF02215 can be used for tumor research.
    RJF02215
  • HY-P3484
    Dnp-PLGLWA-DArg-NH2 TFA
    Dnp-PLGLWA-DArg-NH2 TFA is a fluorogenic substrate for MMP-1 and MMP-9. Dnp-PLGLWA-DArg-NH2 TFA can be used to quantify the activity of MMPs (Ex=280 nm, Em=360 nm).
    Dnp-PLGLWA-DArg-NH2 TFA
  • HY-N0565BR
    Doxycycline hyclate (Standard)
    		Inhibitor
    Doxycycline hyclate (Standard) is the analytical standard of Doxycycline hyclate. This product is intended for research and analytical applications. Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor. Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity.
    Doxycycline hyclate (Standard)
  • HY-P10139
    Dnp-PLGLWAr-NH2
    Dnp-PLGLWAr-NH2 is a synthetic collagenase/gelatinase substrate. Dnp-PLGLWAR-NH2 can be used to quantify total MMP activity in APMA-activated conditioned medium samples.
    Dnp-PLGLWAr-NH2
  • HY-B0689B
    Indinavir sulfate ethanolate
    		Inhibitor
    Indinavir sulfate ethanolate (MK-639 ethanolate) is an orally active and selective HIV-1 protease inhibitor with a Ki of 0.54 nM for PR. Indinavir sulfate ethanolate exhibits anticancer activity by inhibiting the activation of MMPs-2 hydrolysis, anti-angiogenesis and inducing apoptosis. Indinavir sulfate ethanolate is also a SARS-CoV 3CLpro inhibitor.
    Indinavir sulfate ethanolate
  • HY-146105
    Anticancer agent 65
    		Inhibitor
    Anticancer agent 65 (compound 4c) shows excellent activity in cancer cell lines, especially A549 cells, with an IC50 of 1.07 μM. Anticancer agent 65 induces S-phase arrest in A549 cells and increases the expression level of p53 and p21. Anticancer agent 65 causes apoptosis, ROS generation and collapse of MMP in A549 cells.
    Anticancer agent 65
  • HY-110046
    CL-82198 hydrochloride
    		Inhibitor
    CL-82198 hydrochloride is a selective inhibitor of MMP-13. CL-82198 hydrochloride binds to the entire S1’ pocket of MMP-13, which is the basis of its selectivity against MMP-1, MMP-9, and TACE.
    CL-82198 hydrochloride
  • HY-100210
    FN-439
    		Inhibitor
    FN-439 is a selective collagenase-1 inhibitor. FN-439 inhibits collagenase-1 with an IC50 value of 1 μM. FN-439 can be used for the research of cancer and inflammation.
    FN-439
  • HY-134000
    Emodic acid
    Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells.
    Emodic acid
  • HY-112160
    XL-784 free base
    		Inhibitor
    XL-784 free base is a selective matrix metalloproteinases (MMP) inhibitor, with IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1, MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13, respectively.
    XL-784 free base
  • HY-NP123
    Highly purified Type II collagen, from porcine articular cartilage
    Highly purified Type II collagen, from porcine articular cartilage (Porcine Type II collagen, immunization grade) is an immune grade collagen derived from porcine articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type II collagen, from porcine articular cartilage
  • HY-N0431R
    Astragaloside IV (Standard)
    		Inhibitor
    Astragaloside IV (Standard) is the analytical standard of Astragaloside IV. This product is intended for research and analytical applications. Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.
    Astragaloside IV (Standard)
  • HY-N2117R
    Isoginkgetin (Standard)
    		Inhibitor
    Isoginkgetin (Standard) is the analytical standard of Isoginkgetin. This product is intended for research and analytical applications. Isoginkgetin is a pre-mRNA splicing inhibitor inhibitor. Isoginkgetin also inhibits activities of both Akt, NF-κB and MMP-9. Isoginkgetin inhibits the activity of the 20S proteasome, induces apoptosis and activates autophagy.
    Isoginkgetin (Standard)
  • HY-N11643
    Ganoderic acid Mk
    		Inhibitor
    Ganoderic acid Mk (GA-Mk) is a triterpenoid acid, that can be isolated from the mycelia of Ganoderma lucidum. Ganoderic acid Mk is efficiently anti-proliferative and can induce apoptosis of HeLa cells by mitochondria-mediated pathway. Ganoderic acid Mk can be used for cervical cancer research.
    Ganoderic acid Mk
  • HY-N4298
    Epitheaflagallin 3-O-gallate
    		Inhibitor
    Epitheaflagallin 3-O-gallate is a minor polyphenol in black tea. Epitheaflagallin 3-O-gallate exhibits versatile physiological functions in vivo and in vitro, including antioxidative activity, pancreatic lipase inhibition, Streptococcus sorbinusglycosyltransferase inhibition, and an inhibiting effect on the activity of matrix metalloprotease-1 and -3 and their synthesis by human gingival fibroblasts.
    Epitheaflagallin 3-O-gallate
  • HY-NP109
    Highly purified type I collagen, from mouse skin
    Highly purified type I collagen, from mouse skin (Mouse Type I collagen, immunization grade) is an immune grade collagen derived from mouse skin, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified type I collagen, from mouse skin
  • HY-NP121
    Highly purified Type XI collagen, from human sternal cartilage
    Highly purified Type XI collagen, from human sternal cartilage (Human Type XI collagen, immunization grade) is an immune grade collagen derived from human sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type XI collagen, from human sternal cartilage
  • HY-P2166
    MMP3 inhibitor 3
    		Inhibitor
    MMP3 inhibitor 3 is an inhibitor of MMP3. MMP3 inhibitor 3 can used to study breast cancer.
    MMP3 inhibitor 3
  • HY-NP117
    Highly purified Type II collagen, from human sternal cartilage
    Highly purified Type II collagen, from human sternal cartilage (Human Type II collagen, immunization grade) is an immune grade collagen derived from human sternal cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.
    Highly purified Type II collagen, from human sternal cartilage
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
MMP Isoform Comparison

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