2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lipase

Lipase

Lipase is a water-soluble enzyme that can catalyze the ester bond hydrolysis of lipids, decompose and metabolize fat molecules. Lipase is produced primarily by the pancreas and helps the body digest fats and oils. Lipase inhibitors are able to reduce the digestion and absorption of fat, thereby reducing collective caloric intake and weight loss. Lipase inhibitors are commonly used to suppress diseases such as obesity, hyperlipidemia, and pancreatitis.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-128144
    Lalistat 2
    		99.87%
    Lalistat 2 is an inhibitor of many lipases especially Lysosomal acid lipase (LAL, IC50 = 152 nM), which is a key enzyme that degrades neutral lipids at an acidic pH in lysosomes. Lalistat 2 is commonly used to investigate the cell-specific functions of LAL and LAL deficiency in vitro, as well as specifically measure LAL activity in human blood samples or cells .
    Lalistat 2
  • HY-101509
    HSL-IN-1
    		Inhibitor 98.84%
    HSL-IN-1 (compound 24b) is a potent and orally active hormone sensitive lipase (HSL) inhibitor (IC50=2 nM) with a significantly reduced reactive metabolite liability.
    HSL-IN-1
  • HY-102056
    BAY 59-9435
    		Inhibitor 99.75%
    BAY 59-9435 is a potent and selective inhibitor of Hormone Sensitive Lipase (HSL), with an IC50 of 0.023 μM.
    BAY 59-9435
  • HY-117549
    Ibrolipim
    		Activator 99.30%
    Ibrolipim (NO-1886) is an orally active lipoprotein lipase (LPL)-promoting agent. Ibrolipim decreases plasma triglycerides, increases high-density lipoprotein cholesterol levels. Ibrolipim has renoprotective and hypolipidemic effects.
    Ibrolipim
  • HY-Y1422
    Triacylglycerol lipase
    Triacylglycerol lipase is an enzyme catalyzing the hydrolysis of triacylglycerol. Triacylglycerol lipase promotes fat decomposition, providing energy and lipid precursors for cells. Triacylglycerol lipase is used in the research of metabolic diseases such as diabetes and obesity.
    Triacylglycerol lipase
  • HY-164714
    HSL-IN-5
    		Inhibitor 99.83%
    HSL-IN-5 (Example 21) is a hormone sensitive lipase (HSL) inhibitor (IC50: 0.25 μM). HSL-IN-5 can be used for diabetes research.
    HSL-IN-5
  • HY-173296
    MAGL-IN-222
    		Inhibitor
    MAGL-IN-222 (Compound ZQ-7) is a covalent inhibitor targeting monoacylglycerol lipase (MAGL) with an IC50 of 42.31 μM. MAGL-IN-222 can reduce the breakdown of 2-arachidonoylglycerol (2-AG) and increase the intracellular 2-AG level, thereby inhibiting the proliferation and migration of MDA-MB-231 breast cancer cells. MAGL-IN-222 can be used in the research of breast cancer and other related diseases.
    MAGL-IN-222
  • HY-Y0606
    (+)-Camphor-10-sulfonic acid
    		Inhibitor ≥98.0%
    (+)-Camphor-10-sulfonic acid ((+)-10-Camphorsulfonic acid) is an effective pancreatic lipase (PL) inhibitor. (+)-Camphor-10-sulfonic acid is promising for research of obesity.
    (+)-Camphor-10-sulfonic acid
  • HY-153523
    Hi 76-0079
    		Inhibitor 99.90%
    Hi 76-0079 (Compound 31) is a hormone-sensitive lipase (HSL) inhibitor with an IC50 of 184 nM.
    Hi 76-0079
  • HY-23524
    HSL-IN-3
    		Inhibitor ≥98.0%
    HSL-IN-3 (example 42), a boronic acid ester derivative, is an inhibitor of hormone-sensitive lipase (HSL).
    HSL-IN-3
  • HY-N0777
    Isorhamnetin-3-O-glucoside
    		Inhibitor 99.95%
    Isorhamnetin-3-O-glucoside is an orally active natural compound. Isorhamnetin 3-O-glucoside increases P-ERK, ERK, P-Akt (Ser473), P-PI3K, and PDX-1. Isorhamnetin 3-O-glucoside downregulates C/EBPα and inhibits lipase. Isorhamnetin 3-O-glucoside reduces lipids and inhibits obesity.
    Isorhamnetin-3-O-glucoside
  • HY-148755
    ERX-41
    		99.81%
    ERX-41 is an orally active and stereospecific small molecule targeting to lysosomal acid lipase A (LIPA). ERX-41 induces endoplasmic reticulum (ER) stress resulting in cell death, indicating a function independent of LIPA but dependent on its ER localization. ERX-41 involves in a targeted strategy for solid tumors.
    ERX-41
  • HY-103372
    GSK264220A
    		Inhibitor 99.24%
    GSK264220A is a potent endothelial lipase inhibitor with IC50 of 16 nM. GSK264220A has the potential to decrease the risk of cardiovascular disease.
    GSK264220A
  • HY-B0998
    Dehydrocholate sodium
    		Inhibitor 98.01%
    Dehydrocholate sodium is an orally active hydrocholeretic agent. Dehydrocholate sodium modulates Autophagy, reduces serum amylase and lipase levels. Dehydrocholate sodium has the effects of promoting choleretic function, protecting the liver, reducing pancreatic damage, and regulating cholesterol metabolism. Dehydrocholate sodium can be used in the study of acute biliary pancreatitis and obstructive jaundice.
    Dehydrocholate sodium
  • HY-14471
    Cetilistat
    		Inhibitor ≥98.0%
    Cetilistat (ATL-962), an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC50s of 54.8 nM, and 5.95 nM, respectively.
    Cetilistat
  • HY-N6667
    Glucovanillin
    		Inhibitor 99.87%
    Glucovanillin, found in vanilla, is a potential lipase inhibitor. Glucovanillin can be converted into vanillin through an enzyme-coupled process involving cell wall degradation and glucovanillin hydrolysis.
    Glucovanillin
  • HY-N0555
    Escin IB
    		Inhibitor 99.93%
    Escin IB is a saponin isolated from skin and the endosperm of seeds of horse chestnut (Aesculus hippocastanum). Escin IB shows inhibitory effect on pancreatic lipase activity.
    Escin IB
  • HY-W099648
    4-Methylumbelliferyl octanoate
    		99.82%
    4-Methylumbelliferyl octanoate is a octoate. 4-Methylumbelliferyl octanoate can be used as a s ubstrate of hog pancreatic lipase.
    4-Methylumbelliferyl octanoate
  • HY-Y1422D
    Lipase 435
    Lipase 435, an immobilized lipase derived from Candida antarctica fraction B, shows extensive industrial application in producing enantiopure pharmaceuticals, functional lipids, biodiesel, etc. .
    Lipase 435
  • HY-N7668
    Neotheaflavin
    		Inhibitor 99.61%
    Neotheaflavin, from black tea, inhibits pancreatic lipase.
    Neotheaflavin
Cat. No. Product Name / Synonyms Application Reactivity