2. Apoptosis Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Apoptosis MDM-2/p53 MMP Bcl-2 Family Reactive Oxygen Species
  4. Anticancer agent 65

Anticancer agent 65 (compound 4c) shows excellent activity in cancer cell lines, especially A549 cells, with an IC50 of 1.07 μM. Anticancer agent 65 induces S-phase arrest in A549 cells and increases the expression level of p53 and p21. Anticancer agent 65 causes apoptosis, ROS generation and collapse of MMP in A549 cells.

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Anticancer agent 65 Chemical Structure

Anticancer agent 65 Chemical Structure

CAS No. : 2407861-48-5

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Anticancer agent 65 Related Antibodies

Top Publications Citing Use of Products

View All MMP Isoform Specific Products:

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

View All Bcl-2 Family Isoform Specific Products:

View All Isoforms
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • Biological Activity

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Description

Anticancer agent 65 (compound 4c) shows excellent activity in cancer cell lines, especially A549 cells, with an IC50 of 1.07 μM. Anticancer agent 65 induces S-phase arrest in A549 cells and increases the expression level of p53 and p21. Anticancer agent 65 causes apoptosis, ROS generation and collapse of MMP in A549 cells[1].

IC50 & Target

MMP

 

Bcl-2

 

Bax

 

Cellular Effect
Cell Line Type Value Description References
A549 IC50
1.07 μM
Compound: 4c
Antiproliferative activity against human A549 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
[PMID: 31862444]
MCF7 IC50
1.27 μM
Compound: 4c
Antiproliferative activity against human MCF7 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
Antiproliferative activity against human MCF7 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
[PMID: 31862444]
MGC-803 IC50
6.51 μM
Compound: 4c
Antiproliferative activity against human MGC803 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
Antiproliferative activity against human MGC803 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
[PMID: 31862444]
PC-3 IC50
5.44 μM
Compound: 4c
Antiproliferative activity against human PC3 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
Antiproliferative activity against human PC3 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
[PMID: 31862444]
SGC-7901 IC50
7.11 μM
Compound: 4c
Antiproliferative activity against human SGC7901 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
Antiproliferative activity against human SGC7901 cells incubated for 48 hrs and measured after 4 hrs by MTT assay
[PMID: 31862444]
In Vitro

Anticancer agent 65 (compound 4c) increases the expression of Bax and decrease that of Bcl-2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anticancer agent 65 Related Antibodies
Molecular Weight

589.89

Formula

C36H63NO5
CAS No.
SMILES

C[C@]12[C@]3([C@@]([C@@H](C[C@]1([H])[C@@]4([C@@](C(C)([C@H](CC4)OC(C5CCNCC5)=O)C)([H])CC2)C)O)([H])[C@@](CC3)([H])[C@](C)(O)CCCC(C)(O)C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anticancer agent 65 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anticancer agent 652407861-48-5Anticancer agent65Anticancer agent-65ApoptosisMDM-2/p53MMPBcl-2 FamilyReactive Oxygen SpeciesMatrix metalloproteinasesA549 cellsGinsenosideAnti-proliferative activityMitochondrial pathwayInhibitorinhibitorinhibit

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