Emodic acid  (Synonyms: NSC624610)

Emodic acid (NSC624610) is an anthraquinone compound isolated from A. microcarpus, which can inhibit the proliferation of cancer cells by inhibiting the activity of NF-κB. Emodic acid can also inhibit the phosphorylation of p38, ERK and JNK, the secretion of tumor-promoting cytokines IL-1β and IL-6, and the expression of VEGF and MMP, thereby inhibiting the invasion and migration potential of cancer cells^[1].

Emodic acid(0-100 μM, 72 h) exhibits strong antiproliferative activity with the IC₅₀ values of 9.33, 8.56, 7.95 μM in murine mammary carcinoma 4T1, MDA-231 and MCF-7 cell lines, respectively^[1].
Emodic acid (50 μM, 24 h) can significantly inhibit NF-κB transcriptional activity by 80.75%, inhibit p65 phosphorylation and the mRNA expression of MMP-9 in 4T1 cell line^[1].
Emodic acid(50 μM, 24 h) can inhibit the secretion of tumor-promoting cytokines IL-1β and IL-6, as well as the expression of VEGF, thereby inhibiting the invasion and migration of 4T1 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

300.22

C₁₅H₈O₇

478-45-5

OC1=CC(O)=CC(C(C2=C3C(O)=CC(C(O)=O)=C2)=O)=C1C3=O

Room temperature in continental US; may vary elsewhere.

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• [1]. Amira A Abdellatef, et al. Inhibition of cell-intrinsic NF-κB activity and metastatic abilities of breast cancer by aloe-emodin and emodic-acid isolated from Asphodelus microcarpus. J Nat Med. 2021 Sep;75(4):840-853.   [Content Brief]