2. Autophagy Apoptosis Immunology/Inflammation Metabolic Enzyme/Protease NF-κB
  3. Autophagy Apoptosis COX Reactive Oxygen Species
  4. Autophagy inducer 6

Autophagy inducer 6 (Compound 3) inhibits the production of ROS and RNS through inhibition of COX-1 (IC50=15.3 µM) and COX-2 (IC50=4.58 µM). Autophagy inducer 6 generates the formation of autophagosomes, and induces autopagy as a cell protection mechanism. Autophagy inducer 6 induces mild apoptosis. Autophagy inducer 6 inhibits cancer cell MC38, HCT116 and HCT29 with IC50s of 9.5, 11.5 and 17.6 µM, respectively.

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Autophagy inducer 6 Chemical Structure

Autophagy inducer 6 Chemical Structure

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Autophagy inducer 6 Related Antibodies

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Description

Autophagy inducer 6 (Compound 3) inhibits the production of ROS and RNS through inhibition of COX-1 (IC50=15.3 µM) and COX-2 (IC50=4.58 µM). Autophagy inducer 6 generates the formation of autophagosomes, and induces autopagy as a cell protection mechanism. Autophagy inducer 6 induces mild apoptosis. Autophagy inducer 6 inhibits cancer cell MC38, HCT116 and HCT29 with IC50s of 9.5, 11.5 and 17.6 µM, respectively[1].

IC50 & Target

COX-2

15.3 μM (IC50)

COX-1

4.58 μM (IC50)

Molecular Weight

264.51

Formula

C10H19B9N2
SMILES

[H]C123C45([H])B67B89([H]%10)[B-]1%11%10B%12%138B%11(B35%14%15)2B%12%16%15B64%14B%1397%16[N+]%17=C(N)CC%18=C%17C=CC=C%18
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Autophagy inducer 6 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Autophagy inducer 6Autophagy inducer6Autophagy inducer-6AutophagyApoptosisCOXReactive Oxygen SpeciesCyclooxygenaseMC38HCT116HT29Inhibitorinhibitorinhibit

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