Anion Exchangers

Anion Exchangers are a critical class of transmembrane proteins that primarily facilitate the exchange of anions, such as Cl^-, HCO₃^-, and SO₂^2-, between the intracellular and extracellular environment through the antiport mechanism. Anion Exchangers mainly include members of the solute carrier 4 (SLC4) and solute carrier 26 (SLC26) families, such as AE1 (SLC4A1), AE2 (SLC4A2), AE3 (SLC4A3), DRA (SLC26A3), and PAT1 (SLC26A6), which are widely distributed in tissues such as red blood cells, kidneys, and the digestive tract.
Anion Exchangers play a pivotal role in physiological processes such as maintaining acid-base balance, ion homeostasis, and metabolite excretion. Dysfunction of these proteins is closely associated with various diseases, including hereditary distal renal tubular acidosis, metabolic disorders, and abnormal regulation of the tumor microenvironment^[1]^[2].

References:

[1]. Alper SL. Molecular physiology of SLC4 anion exchangers. Exp Physiol. 2006 Jan;91(1):153-61.

[2]. Mount DB, et al. The SLC26 gene family of multifunctional anion exchangers. Pflugers Arch. 2004 Feb;447(5):710-21.

Anion Exchangers Inhibitors (2)

Anion Exchangers Related Products (2):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-138866

Dimethylamiloride	Inhibitor	98.28%
Dimethylamiloride is a specific antiporter inhibitor.

HY-122671

OB-1	Inhibitor	99.12%
OB-1 is a stomatin-like protein-3 (STOML3) oligomerization blocker. OB-1 is an effective inhibitor of the self-association of Stomatin, STOML1 and STOML2, but not podocin.

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