2. Signaling Pathways
  3. Immunology/Inflammation
  4. C-type Lectin-like Receptors (CTLRs)

C-type Lectin-like Receptors (CTLRs)

C-type Lectin-like Receptors (CTLRs)

C-type Lectin-like Receptors (CTLRs) are a class of protein receptors that contain a C-type lectin-like domain but do not necessarily rely on calcium ions to recognize ligands. They are usually classified as activating or inhibitory receptors, based on their intracellular signaling motifs. CTLRs are capable of recognizing pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), and play important roles in innate and adaptive immunity. After binding to ligands, CLRs act as antigen-uptake receptors, internalize antigens and present them to T cells, and activate multiple signaling pathways such as NF-κB, IFN, and inflammasomes to regulate the functions of immune cells. Abnormal expression or function of CLRs is closely related to cancer, infectious diseases, autoimmune diseases, and others[1][2].

C-type Lectin-like Receptors (CTLRs) Related Products (9):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P9990
    Litifilimab
    		Inhibitor 99.42%
    Litifilimab is a humanized IgG1-κ antibody targeting to C-type lectin domain family 4 member C (CLEC4C). Litifilimab can be used for cutaneous lupus erythematosus (CLE) study.
    Litifilimab
  • HY-P990026
    Ulviprubart
    		Modulator
    Ulviprubart (ABC-008) is a monoclonal antibody targeting the KLRG1 receptor that selectively depletes highly differentiated cytotoxic T cells. Ulviprubart can be used in the study of inclusion body myositis (IBM).
    Ulviprubart
  • HY-153489
    ISIS 329993
    		Inhibitor
    ISIS 329993 (ISIS-CRPRx) is an antisense oligonucleotide targeting to C-reactive protein (CRP). ISIS-CRPRx has been tested in a rodent model of rheumatoid arthritis (RA) and was shown to improve the clinical signs of arthritis
    ISIS 329993
  • HY-155311
    NKG2D-IN-1
    		Inhibitor
    NKG2D-IN-1 (compound 21) is a natural killer group 2D receptor (NKG2D) inhibitor with IC50s of 0.3 µM and 0.7 µM in NKG2D/MICA and ULBP6 TR-FRET assays, respectively.
    NKG2D-IN-1
  • HY-P990372
    Anti-CLEC14A Antibody
    The Anti-CLEC14A Antibody is a humanized antibody expressed in CHO cells, targeting CLEC14A. The Anti-CLEC14A Antibody contains an IgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-CLEC14A Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-CLEC14A Antibody
  • HY-P990373
    Anti-CLEC4C Antibody
    Anti-CLEC4C Antibody is a CHO-expressed humanized antibody that targets CLEC4C. The Anti-CLEC4C Antibody carries a huIgG1 type heavy chain and a huλ type light chain, with a predicted molecular weight (MW) of 150 kDa.
    Anti-CLEC4C Antibody
  • HY-P990265
    Anti-Mouse CD69 Antibody (CD69.2.2)
    Anti-Mouse CD69 Antibody (CD69.2.2) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to mouse CD69.
    Anti-Mouse CD69 Antibody (CD69.2.2)
  • HY-153489A
    ISIS 329993 sodium
    		Inhibitor
    ISIS 329993 sodium is an antisense oligonucleotide targeting to C-reactive protein (CRP). ISIS-CRPRx sodium has been tested in a rodent model of rheumatoid arthritis (RA) and was shown to improve the clinical signs of arthritis
    ISIS 329993 sodium
  • HY-W159303
    7-Hydroxy-2,2-dimethyl-4-chromanone
    		Inhibitor
    7-Hydroxy-2,2-dimethyl-4-chromanone (compound 41) is an inhibitor of DC-SIGN (Dendritic Cell-Specific Intercellular Adhesion Molecule 3 grabbing non-integrin), with an IC50 of 4.66 mM. DC-SIGN is the C-type lectin receptor presenting on the surface of both macrophages and dendritic cells.
    7-Hydroxy-2,2-dimethyl-4-chromanone