GCN1 - GCN1 activator of EIF2AK4 Gene

Homo sapiens

Also known as GCN1L; GCN1L1; PRIC295

Gene ID: 10985 | Gene type: protein coding

About GCN1

Cytogenetic location: 12q24.23 Genomic coordinates (GRCh38): 12:120,127,202-120,194,715 (from NCBI)

This gene has 9 transcripts (splice variants), 205 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 14.2), thyroid (RPKM 12.3) and 25 other tissues.

Summary

Enables RNA binding activity and cadherin binding activity. Predicted to be involved in cellular response to leucine starvation and positive regulation of transcription from RNA polymerase II promoter in response to stress. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

GCN1 Products(1)

mRNA	Protein	Name
NM_006836.2	NP_006827.1	eIF-2-alpha kinase activator GCN1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	36638793	GOA
enables stalled ribosome sensor activity	IDA IDA: Inferred from direct assay	36638793	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein-RNA covalent cross-linking repair	IDA IDA: Inferred from direct assay	37951215	GOA
involved in rescue of stalled ribosome	IDA IDA: Inferred from direct assay	36638793	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in cytosolic ribosome	IDA IDA: Inferred from direct assay	36638793	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GCN1 Protein Structure

Gcn1_N

HEAT_2

0
500
1000
1500
2000
2500
2671 a.a.

Protein Preferred Names

Protein Names

eIF-2-alpha kinase activator GCN1

GCN1 (general control of amino-acid synthesis 1, yeast)-like 1

Related Diseases

Diseases

Alias

Ogden Syndrome

OGDNS	N-Terminal Acetyltransferase Deficiency
NATD	N-Alpha-Acetyltransferase
X-Linked Malformation And Infantile Lethality Syndrome	Premature Aging Appearance-Developmental Delay-Cardiac Arrhythmia Syndrome

Myopathy, Centronuclear, 2

Myopathy, Centronuclear, Autosomal Recessive	Autosomal Recessive Centronuclear Myopathy
CNM2	Centronuclear Myopathy 2
Ar-Cnm	Myotubular Myopathy, Autosomal Recessive
Autosomal Recessive Myotubular Myopathy	Centronuclear Myopathy Autosomal Recessive
Myopathy, Centronuclear, Type 2

Hydrarthrosis

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05337	GCN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	GCN1	RGD	RGD:1593434
Canis familiaris	GCN1	VGNC	VGNC:41151
Mus musculus	GCN1	MGD	MGI:2444248
Macaca mulatta	GCN1	VGNC	VGNC:72905
Bos taurus	GCN1	VGNC	VGNC:29292
Felis catus	GCN1	VGNC	VGNC:62496

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