EDN2 - endothelin 2 Gene

Homo sapiens

Also known as ET2; ET-2; PPET2

Gene ID: 1907 | Gene type: protein coding

About EDN2

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:41,478,775-41,484,683 (from NCBI)

This gene has 5 transcripts (splice variants), 267 orthologues and 2 paralogues. Biased expression in small intestine (RPKM 7.3), esophagus (RPKM 3.9) and 5 other tissues.

Summary

This gene encodes a member of the endothelin protein family of secretory vasoconstrictive Peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

EDN2 Products(2)

mRNA	Protein	Name
NM_001302269.2	NP_001289198.1	endothelin-2 isoform 2 preproprotein
NM_001956.5	NP_001947.1	endothelin-2 isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables hormone activity	IDA IDA: Inferred from direct assay	2649896	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in artery smooth muscle contraction	IDA IDA: Inferred from direct assay	8982507	GOA
involved in cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	12207323	GOA
involved in macrophage activation	IDA IDA: Inferred from direct assay	12207323	GOA
involved in macrophage chemotaxis	IDA IDA: Inferred from direct assay	12207323	GOA
involved in neutrophil chemotaxis	IDA IDA: Inferred from direct assay	9696419	GOA
involved in positive regulation of calcium-mediated signaling	IDA IDA: Inferred from direct assay	1917960	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	1917960	GOA
involved in positive regulation of heart rate	IDA IDA: Inferred from direct assay	2649896	GOA
involved in positive regulation of leukocyte chemotaxis	IDA IDA: Inferred from direct assay	9696419	GOA
involved in positive regulation of prostaglandin-endoperoxide synthase activity	IMP IMP: Inferred from mutant phenotype	9492062	GOA
involved in prostaglandin biosynthetic process	IDA IDA: Inferred from direct assay	9492062	GOA
involved in regulation of systemic arterial blood pressure by endothelin	IDA IDA: Inferred from direct assay	2649896	GOA
involved in vasoconstriction	IDA IDA: Inferred from direct assay	2649896	GOA
involved in vein smooth muscle contraction	IDA IDA: Inferred from direct assay	8982507	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	15691296	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EDN2 Protein Structure

Endothelin

0
100
178 a.a.

Protein Preferred Names

Protein Names

endothelin-2

preproendothelin 2

Related Diseases

Diseases

Alias

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Li-Fraumeni Syndrome 1

Lfs1

Cardiovascular System Disease

Abnormality Of The Cardiovascular System	Cardiovascular Disease
Disease Of Subdivision Of Hemolymphoid System	Disorder Of Cardiovascular System
Cardiovascular Diseases

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Primitive Neuroectodermal Tumor	Ewings Sarcoma
Ewing'S Sarcoma	Peripheral Neuroepithelioma
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Ewing Family Of Tumors	Extraosseous Ewing Tumor
Askin Tumor	Ewing'S Family Localized Tumor
Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing Sarcoma
Localized Ewing'S Sarcoma	Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing'S Tumor	Pnet Of Thoracopulmonary Region
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04164	EDN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EDN2	MGD	MGI:95284
Macaca mulatta	EDN2	VGNC	VGNC:72157
Rattus norvegicus	EDN2	RGD	RGD:2533
Canis familiaris	EDN2	VGNC	VGNC:40200
Bos taurus	EDN2	VGNC	VGNC:28328
Felis catus	EDN2	VGNC	VGNC:61727

Name
Email *

	Sorry, but the email address you supplied was invalid.