DUOX1 - dual oxidase 1 Gene

Homo sapiens

Also known as LNOX1; THOX1; NOXEF1

Gene ID: 53905 | Gene type: protein coding

About DUOX1

Cytogenetic location: 15q21.1 Genomic coordinates (GRCh38): 15:45,129,994-45,165,574 (from NCBI)

This gene has 13 transcripts (splice variants), 94 orthologues and 6 paralogues. Biased expression in skin (RPKM 27.3), thyroid (RPKM 26.8) and 8 other tissues.

Summary

The protein encoded by this gene is a glycoprotein and a member of the NADPH Oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes proteins encoded by this gene and the similar DUOX2 gene. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. This protein generates hydrogen peroxide and thereby plays a role in the activity of thyroid peroxidase, lactoperoxidase, and in lactoperoxidase-mediated antimicrobial defense at mucosal surfaces. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2012]

DUOX1 Products(2)

mRNA	Protein	Name
NM_017434.5	NP_059130.2	dual oxidase 1 precursor
NM_175940.3	NP_787954.1	dual oxidase 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19339556	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cuticle development	IMP IMP: Inferred from mutant phenotype	11514595	GOA
involved in cytokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	16111680	GOA
involved in hydrogen peroxide biosynthetic process	IGI IGI: Inferred from genetic interaction	19339556	GOA
involved in positive regulation of cell motility	IGI IGI: Inferred from genetic interaction	19339556	GOA
involved in positive regulation of wound healing	IGI IGI: Inferred from genetic interaction	19339556	GOA
involved in response to cAMP	IDA IDA: Inferred from direct assay	15062544	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell leading edge	IGI IGI: Inferred from genetic interaction	19339556	GOA
located in cell surface	IGI IGI: Inferred from genetic interaction	22814254	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	19339556	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19339556	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DUOX1 Protein Structure

An_peroxidase

EF-hand_7

Ferric_reduct

FAD_binding_8

NAD_binding_6

0
300
600
900
1200
1551 a.a.

Protein Preferred Names

Protein Names

dual oxidase 1

NADPH thyroid oxidase 1

DUOX1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DUOX1	Q9NRD9	DUOXA1	Homo sapiens	Q1HG43	GMS	33420071
Intra	DUOX1	Q9NRD9	DUOXA1	Homo sapiens	Q1HG43	UV-VIS	33420071
Intra	DUOX1	Q9NRD9	DUOXA1	Homo sapiens	Q1HG43	3D-EM	33420071

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Congenital Hypothyroidism

Cretinism	Neonatal Hypothyroidism
Ch	Cht
Congenital Myxedema	Myxedema, Congenital
Endemic Cretinism	Congenital Iodine-Deficiency Syndrome
Fetal Iodine Deficiency Syndrome	Congenital Iodine-Deficiency Hypothyroidism Nos

Granulomatous Disease, Chronic, Autosomal Recessive, 4

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Negative	Cyba Deficiency
CGD4	Cgd Due To Deficiency Of The Alpha Subunit Of Cytochrome B
Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Negative	Cgd, Autosomal Recessive Cytochrome B-Negative
Chronic Granulomatous Disease 4, Autosomal Recessive	Autosomal Recessive Chronic Granulomatous Disease 4
Autosomal Recessive Cytochrome B-Negative Cgd	Chronic Granulomatous Disease Due To Deficiency Of Cyba
Cgd Due To Deficiency Of Alpha Subunit Of Cytochrome B	Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Negative
Granulomatous Disease, Chronic, Cytochrome-B-Negative, Autosomal Recessive

Phagocyte Bactericidal Dysfunction

Phagocytic Dysfunction

Hypothyroidism

Thyroid Diseases	Thyroid Disease
Thyroid Deficiency	Thyroid Insufficiency
Dysfunction Thyroid	Thyroid Dysfunction

Granulomatous Disease, Chronic, X-Linked

CGDX	Chronic Granulomatous Disease, X-Linked
X-Linked Chronic Granulomatous Disease	Cgd
Cytochrome B-Negative Granulomatous Disease, Chronic, X-Linked	Cdgx
X-Linked Chronic Cytochrome B-Negative Granulomatous Disease	Chronic Granulomatous Disease Cytochrome B-Negative X-Linked
Chronic Granulomatous Disease Cytochrome B-Positive X-Linked	Granulomatous Disease, Chronic, X-Linked, Variant

Chronic Granulomatous Disease

Cgd	Granulomatous Disease, Chronic
Autosomal Recessive Chronic Granulomatous Disease	X-Linked Chronic Granulomatous Disease
Bridges-Good Syndrome	Congenital Dysphagocytosis
Quie Syndrome	Chronic Septic Granulomatosis
Chronic Granulomatous Disorder	Granulomatous Disease Chronic
Granulomatous Disease, Chronic, X-Linked

Lung Disease

Lung Diseases	Disorder Of Lung
Abnormality Of The Lung

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04044	DUOX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	DUOX1	VGNC	VGNC:28241
Canis familiaris	DUOX1	VGNC	VGNC:40120
Rattus norvegicus	DUOX1	RGD	RGD:628760
Macaca mulatta	DUOX1	VGNC	VGNC:72009
Mus musculus	DUOX1	MGD	MGI:2139422
Felis catus	DUOX1	VGNC	VGNC:61653

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