LIMS2 - LIM zinc finger domain containing 2 Gene

Homo sapiens

Also known as LGMD2W; PINCH2; MDRCMTT; PINCH-2

Gene ID: 55679 | Gene type: protein coding

About LIMS2

Cytogenetic location: 2q14.3 Genomic coordinates (GRCh38): 2:127,638,426-127,681,786 (from NCBI)

This gene has 18 transcripts (splice variants), 277 orthologues, 3 paralogues and is associated with 2 phenotypes. Broad expression in endometrium (RPKM 24.9), fat (RPKM 20.9) and 23 other tissues.

Summary

This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

LIMS2 Products(5)

mRNA	Protein	Name
NM_001136037.4	NP_001129509.2	LIM and senescent cell antigen-like-containing domain protein 2 isoform 1
NM_001161403.3	NP_001154875.1	LIM and senescent cell antigen-like-containing domain protein 2 isoform 3
NM_001161404.2	NP_001154876.1	LIM and senescent cell antigen-like-containing domain protein 2 isoform 5
NM_001256542.2	NP_001243471.1	LIM and senescent cell antigen-like-containing domain protein 2 isoform 4
NM_017980.5	NP_060450.2	LIM and senescent cell antigen-like-containing domain protein 2 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LIMS2 Protein Structure

LIM

0
100
200
300
341 a.a.

Protein Preferred Names

Protein Names

LIM and senescent cell antigen-like-containing domain protein 2

ILK-binding protein

Related Diseases

Diseases

Alias

Muscular Dystrophy, Autosomal Recessive, With Cardiomyopathy And Triangular Tongue

Muscular Dystrophy, Limb-Girdle, Type 2w	Lgmd2w
MDRCMTT	Lims2-Related Limb-Girdle Muscular Dystrophy
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2w	Lgmd Type 2w
Lims2-Related Lgm	Limb-Girdle Muscular Dystrophy Type 2w
Limb-Girdle Muscular Dystrophy 2w

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2w

Lgmd2w

Muscular Dystrophy, Limb-Girdle, Type 2w

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 2

Lgmd2b	Muscular Dystrophy, Limb-Girdle, Type 2b
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2e	Beta-Sarcoglycanopathy
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2y	Muscular Dystrophy, Limb-Girdle, Type 3
Lgmd3	Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2s
LGMDR2	Muscular Dystrophy, Limb-Girdle, Type 2s
Limb-Girdle Muscular Dystrophy Type 2b	Lgmd2e
Limb-Girdle Muscular Dystrophy Due To Beta-Sarcoglycan Deficiency	Muscular Dystrophy, Limb-Girdle, Type 2e
Lgmd2s	Autosomal Recessive Muscular Dystrophy Due To Lap1b Deficiency
Autosomal Recessive Muscular Dystrophy Due To Torsin-1a-Interacting Protein 1 Deficiency	Lgmd2y
Muscular Dystrophy With Progressive Weakness, Distal Contractures And Rigid Spine	Muscular Dystrophy, Limb-Girdle, Type 2y
Dysferlin-Related Limb-Girdle Muscular Dystrophy R2	Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2b
Dysferlin-Related Lgmd R2	Lgmd Due To Dysferlin Deficiency
Lgmd Type 2b	Limb-Girdle Muscular Dystrophy Due To Dysferlin Deficiency
Limb-Girdle Muscular Dystrophy 2b	Limb-Girdle Muscular Dystrophy, Type 2b
Dystrophy, Muscular, Limb-Girdle, Autosomal Recessive, Type 2	Dystrophy, Muscular, Limb-Girdle, Type 2b
Limb-Girdle Muscular Dystrophy, Type 2e

Muscular Dystrophy-Dystroglycanopathy , Type C, 14

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2t	Lgmd2t
MDDGC14	Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 19
Lgmdr19	Muscular Dystrophy Limb-Girdle Type 2t
Muscular Dystrophy-Dystroglycanopathy Limb-Girdle Gmppb-Related	Muscular Dystrophy, Limb-Girdle, Type 2t
Muscular Dystrophy-Dystroglycanopathy, Limb-Girdle, Gmppb-Related	Muscular Dystrophy-Dystroglycanopathy Type C14
Gmppb-Related Limb-Girdle Muscular Dystrophy R19	Gmppb-Related Lgmd R19
Lgmd Type 2t	Limb-Girdle Muscular Dystrophy Type 2t
Muscular Dystrophy-Dystroglycanopathy Limb-Girdle C14	Dystrophy, Muscular, Limb-Girdle, Type 2t

Muscular Dystrophy-Dystroglycanopathy , Type C, 7

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2u	Lgmd2u
MDDGC7	Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 20
Lgmdr20	Muscular Dystrophy, Limb-Girdle, Type 2u
Autosomal Recessive Limb-Girdle Muscular Dystrophy Due To Ispd Deficiency	Muscular Dystrophy Limb-Girdle Type 2u
Muscular Dystrophy-Dystroglycanopathy Type C7	Ispd-Related Limb-Girdle Muscular Dystrophy R20
Ispd-Related Lgmd R20	Lgmd Type 2u
Limb-Girdle Muscular Dystrophy Type 2u	Muscular Dystrophy-Dystroglycanopathy Limb-Girdle C7
Dystrophy, Muscular, Dystroglycanopathy, Type C7

Muscular Dystrophy-Dystroglycanopathy , Type C, 9

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2p	Lgmd2p
MDDGC9	Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 16
Lgmdr16	Muscular Dystrophy-Dystroglycanopathy Limb-Girdle Dag1-Related
Muscular Dystrophy, Limb-Girdle, Type 2p	Muscular Dystrophy-Dystroglycanopathy, Limb-Girdle, Dag1-Related
Muscular Dystrophy-Dystroglycanopathy Type C9	Alpha-Dystroglycan-Related Limb-Girdle Muscular Dystrophy R16
Alpha-Dystroglycan-Related Lgmd R16	Lgmd Type 2p
Limb-Girdle Muscular Dystrophy Type 2p	Muscular Dystrophy-Dystroglycanopathy Limb-Girdle C9
Muscular Dystrophy Limb-Girdle Type 2p	Dystrophy, Muscular, Limb-Girdle, Type 2p

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2x

Lgmd2x

Muscular Dystrophy, Limb-Girdle, Type 2x

Macroglossia

Congenital Macroglossia	Enlarged Tongue
Giant Tongue	Acquired Macroglossia Nos
Congenital Hypertrophy Of Tongue

Muscular Dystrophy, Limb-Girdle, Autosomal Dominant 3

Lgmd1g	Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1g
LGMDD3	Muscular Dystrophy, Limb-Girdle, Type 1g
Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 3	Limb-Girdle Muscular Dystrophy, Type 1g
Muscular Dystrophy Limb-Girdle Type 1g	Hnrnpdl-Related Limb-Girdle Muscular Dystrophy D3
Hnrnpdl-Related Lgmd D3	Lgmd Type 1g
Limb-Girdle Muscular Dystrophy Type 1g	Limb-Girdle Muscular Dystrophy 1g
Dystrophy, Muscular, Limb-Girdle, Type 1g

Muscular Dystrophy, Limb-Girdle, Type 1h

Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1h	LGMD1H
Muscular Dystrophy Limb-Girdle Type 1h	Dystrophy, Muscular, Limb-Girdle, Type 1h

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Myopathy, Myofibrillar, 8

Myofibrillar Myopathy 8	MFM8
Myopathy, Myofibrillar, Type 8

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2q

Autosomal Recessive Limb-Girdle Muscular Dystrophy Due To Plectin Deficiency	Lgmd2q
Muscular Dystrophy, Limb-Girdle, Type 2q

Myopathy, Myofibrillar, 7

Myofibrillar Myopathy 7	MFM7
Kyphosis-Lateral Tongue Atrophy-Myofibrillar Myopathy Syndrome	Myopathy, Myofibrillar, Type 7

Myopathy, Centronuclear, 5

CNM5	Centronuclear Myopathy 5
Myopathy, Centronuclear, Type 5

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07656	LIM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS07669	LIMS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LIMS2	VGNC	VGNC:42682
Macaca mulatta	LIMS2	VGNC	VGNC:74054
Felis catus	LIMS2	VGNC	VGNC:63230
Mus musculus	LIMS2	MGD	MGI:2385067
Bos taurus	LIMS2	VGNC	VGNC:30891
Rattus norvegicus	LIMS2	RGD	RGD:1305273

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