SHCBP1 - SHC binding and spindle associated 1 Gene

Homo sapiens

Also known as PAL

Gene ID: 79801 | Gene type: protein coding

About SHCBP1

Cytogenetic location: 16q11.2 Genomic coordinates (GRCh38): 16:46,578,591-46,621,379 (from NCBI)

This gene has 7 transcripts (splice variants), 143 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 5.2), lymph node (RPKM 5.2) and 25 other tissues.

Summary

Predicted to enable SH2 domain binding activity. Predicted to be involved in Fibroblast Growth Factor receptor signaling pathway and regulation of neural precursor cell proliferation. Predicted to be located in cytoplasm; midbody; and spindle. [provided by Alliance of Genome Resources, Apr 2022]

SHCBP1 Products(3)

mRNA	Protein	Name
NM_001324318.2	NP_001311247.1	SHC SH2 domain-binding protein 1 isoform 2
NM_001324319.2	NP_001311248.1	SHC SH2 domain-binding protein 1 isoform 3
NM_024745.5	NP_079021.4	SHC SH2 domain-binding protein 1 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25852190	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SHCBP1 Protein Structure

Beta_helix

0
200
400
600
672 a.a.

Protein Preferred Names

Protein Names

SHC SH2 domain-binding protein 1

Protein expressed in Activated Lymphocytes

Related Diseases

Diseases

Alias

Desmoid Disease, Hereditary

Fif	DESMD
Hereditary Desmoid Disease	Familial Infiltrative Fibromatosis
Fibromatosis, Familial Infiltrative	Fibromatosis, Aggressive

Hermansky-Pudlak Syndrome 3

HPS3	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial
Delta Storage Pool Disease	Hermansky-Pudlak Syndrome, Type 3
Platelet Storage Pool Deficiency	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12860	SHCBP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SHCBP1	VGNC	VGNC:34592
Felis catus	SHCBP1	VGNC	VGNC:65119
Rattus norvegicus	SHCBP1	RGD	RGD:1590844
Macaca mulatta	SHCBP1	VGNC	VGNC:77339
Mus musculus	SHCBP1	MGD	MGI:1338802
Canis familiaris	SHCBP1	VGNC	VGNC:46143

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