2. Epigenetics Neuronal Signaling
  3. Histone Demethylase Monoamine Oxidase
  4. LSD1-IN-17

LSD1-IN-17 (compound 5b) is a potent LSD1 inhibitor. LSD1-IN-17 can inhibit LSD1-CoREST, MAO-A and MAO-B, with IC50 values of 0.005, 0.028, and 0.820 μM, respectively. LSD1-IN-17 displays cell growth arrest in prostate cancer LNCaP cells, with an IC50 of 17.2 μM.

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LSD1-IN-17 Chemical Structure

LSD1-IN-17 Chemical Structure

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LSD1-IN-17 Related Antibodies

Top Publications Citing Use of Products

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KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6 KDM7

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MAO-A MAO-B

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Description

LSD1-IN-17 (compound 5b) is a potent LSD1 inhibitor. LSD1-IN-17 can inhibit LSD1-CoREST, MAO-A and MAO-B, with IC50 values of 0.005, 0.028, and 0.820 μM, respectively. LSD1-IN-17 displays cell growth arrest in prostate cancer LNCaP cells, with an IC50 of 17.2 μM[1].

IC50 & Target

MAO-A

0.028 ± 0. μM (IC50)

MAO-B

0.820 ± 0. μM (IC50)

Molecular Weight

334.43

Formula

C20H18N2OS
SMILES

NC1CC1C2=CC=C(C=C2)NC(C3=CC=CC(C4=CSC=C4)=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LSD1-IN-17 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LSD1-IN-17Histone DemethylaseMonoamine OxidaseMAOLNCaP cellsU937 cellstranylcypromine (TCP)TCP derivativeprostate cancerLysine-specific demethylase 1 (LSD1)monoamine oxidase (MAO)Inhibitorinhibitorinhibit

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