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Adrenaline receptors

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11

Inhibitors & Agonists

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W014728
    N-Methyldopamine hydrochloride

    		Dopamine Receptor Cardiovascular Disease Neurological Disease
    N-Methyldopamine hydrochloride is a precursor of adrenaline in the adrenal medulla. N-Methyldopamine hydrochloride is a modification of the dopamine (DA), and retains agonist activity at the DA1 receptor. N-Methyldopamine hydrochloride remains capable of universal surface coating and secondary reactions using the surface catechols. N-Methyldopamine hydrochloride can be used for heart failure research .
    N-Methyldopamine hydrochloride
  • HY-106617
    Etoperidone

    		5-HT Receptor Adrenergic Receptor Neurological Disease
    Etoperidone, an antidepressant agent, is an orally active serotonin and nor-adrenaline re-uptake antagonist. Etoperidone shows Kd values of 36 nM, 38 nM, 85 nM, and 570 nM for 5-HT2 receptor, α1-adrenergic receptor, 5-HT1A receptor, and α2-adrenergic receptor, respectively .
    Etoperidone
  • HY-123311
    CP59430

    		Adrenergic Receptor Endocrinology
    CP59430 is an azide analog of the α-adrenaline receptor antagonist Prazosin (HY-B0193). P59430 behaves as a competitive antagonist of α1-adrenaline receptor before photolysis. After photolysis, it specifically and irreversibly labels α1-adrenaline receptor and exhibits non-competitive antagonist activity. CP59430 can be used for the study of receptor molecular characterization .
    CP59430
  • HY-105562
    Nadoxolol

    		Adrenergic Receptor Cardiovascular Disease
    Nadoxolol is a non-selective β-adrenaline receptor blocker that can be used in the study of arrhythmias. .
    Nadoxolol
  • HY-118260
    Phendioxan

    		Adrenergic Receptor Endocrinology
    Phendioxan is a compound with binding activity at the α(1)-adrenaline receptor subtype. The facilitated membrane diffusion of phendioxan is thought to be associated with improved α(1d)-AR affinity. Docking simulations of phendioxan at biological targets supported the stoichiometric analysis and revealed the importance of polar, electrostatic, hydrophobic, and shape effects of its phenoxy terminal orthogonal substituents on ligand binding .
    Phendioxan
  • HY-106617A
    Etoperidone hydrochloride

    		5-HT Receptor Adrenergic Receptor Neurological Disease
    Etoperidone hydrochloride, an antidepressant agent, is an orally active serotonin and nor-adrenaline re-uptake antagonist. Etoperidone hydrochloride shows Kd values of 36 nM, 38 nM, 85 nM, and 570 nM for 5-HT2 receptor, α1-adrenergic receptor, 5-HT1A receptor, and α2-adrenergic receptor, respectively .
    Etoperidone hydrochloride
  • HY-101355
    CGP 20712

    		Adrenergic Receptor Cardiovascular Disease
    CGP 20712 is a highly selective β1-adrenoceptor antagonist (Ki=0.3 nmol/L). CGP 20712’s primary mechanism of action is through competitively binding to β1-receptors, thereby blocking the positive chronotropic effects of adrenaline and noradrenaline .
    CGP 20712
  • HY-129668
    Bremazocine

    		Adrenergic Receptor Neurological Disease
    Bremazocine is a potent opioid kappa receptor agonist with analgesic activity. Bremazocine induces peripheral analgesia by releasing endogenous norepinephrine. The analgesic effect of bremazocine is associated with interaction with adenosine receptors. Bremazocine produces a dose-dependent peripheral analgesia after topical application. The effect of bremazocine is affected by nonselective α(2) adrenaline receptor antagonists, suggesting that it acts through a norepinephrine pathway .
    Bremazocine
  • HY-106512
    Cianergoline

    		Prostaglandin Receptor Others
    Cianergoline is a ergoline derivative with the activity of reducing intraocular pressure (IOP). Its primary regulatory mechanism involves the inhibition of sympathetic nervous function, achieved through actions on both prejunctional (DA2) and postjunctional (α1) adrenergic receptors. Cianergoline can be used for research in the field of glaucoma .
    Cianergoline
  • HY-117379
    CHIR-2279

    		Adrenergic Receptor Others
    CHIR-2279 is a high-affinity ligand (Ki=5 nM) for the α1-adrenergic receptor and can be further studied as a drug lead compound .
    CHIR-2279
  • HY-106769B
    (3aR,9aR)-Fluparoxan

    (3aR,9aR)-GR50360

    		 Others Neurological Disease
    (3aR,9aR)-Fluparoxan ((3aR,9aR)-GR50360) is a highly selective and potent α2B adrenaline receptor antagonist with the activity of preventing, improving or inhibiting neurodevelopmental disorders and neurodegenerative diseases. As an α2B receptor antagonist, (3aR,9aR)-Fluparoxan can promote the recovery of neurological function. The mechanism of action of (3aR,9aR)-Fluparoxan makes it have important application potential in neuroscience research .
    (3aR,9aR)-Fluparoxan

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