2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. CGP 20712

CGP 20712 is a highly selective β1-adrenoceptor antagonist (Ki=0.3 nmol/L). CGP 20712’s primary mechanism of action is through competitively binding to β1-receptors, thereby blocking the positive chronotropic effects of adrenaline and noradrenaline.

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CGP 20712 Chemical Structure

CGP 20712 Chemical Structure

CAS No. : 137888-49-4

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Other Forms of CGP 20712:

CGP 20712 Related Antibodies

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Description

CGP 20712 is a highly selective β1-adrenoceptor antagonist (Ki=0.3 nmol/L). CGP 20712’s primary mechanism of action is through competitively binding to β1-receptors, thereby blocking the positive chronotropic effects of adrenaline and noradrenaline[1].

Cellular Effect
Cell Line Type Value Description References
CHO-K1 EC50
10 μM
Compound: CGP 20712A
Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
Agonist activity at human beta2 adrenoceptor expressed in CHOK1 cells assessed as induction of [3H]cAMP accumulation after 5 hrs
[PMID: 23614528]
Molecular Weight

494.46

Formula

C23H25F3N4O5
CAS No.
SMILES

O=C(N)C1=CC(OCCNCC(O)COC2=CC=C(C3=NC(C(F)(F)F)=CN3C)C=C2)=CC=C1O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CGP 20712 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CGP 20712137888-49-4CGP20712CGP-20712Adrenergic ReceptorBeta ReceptorPositive time-varying effect blockingAdrenalineNorepinephrineInhibitorinhibitorinhibit

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