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Isoforms Recommended: CDC
Results for "

CDC42

" in MedChemExpress (MCE) Product Catalog:

29

Inhibitors & Agonists

3

Natural
Products

8

Recombinant Proteins

3

Antibodies

6

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-136379
    CID44216842
    1 Publications Verification

    CDC42-IN-1

    Ras Cancer
    CID44216842 (Cdc42-IN-1) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 0.3 and 0.5 μM in GDP binding assay, respectively. Use as a molecular probe .
    CID44216842
  • HY-13963
    ZCL278
    2 Publications Verification

    Flavivirus Dengue virus VSV Ras Cancer
    ZCL278 is a selective Cdc42 modulator that directly binds to Cdc42 and inhibits its functions with Kd of 11.4 μM for Cdc42-ZCL278 affinity in surface plasmon resonance (SPR) experiment.
    ZCL278
  • HY-136383
    AZA1
    1 Publications Verification

    Rac1/CDC42-IN-1

    Ras Apoptosis Cancer
    AZA1 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induces prostate cancer cells apoptosis and inhibits prostate cancer cells proliferation, migration and invasion .
    AZA1
  • HY-113849
    MLS-573151
    1 Publications Verification

    MLS000573151

    Ras Inflammation/Immunology
    MLS-573151 (MLS000573151) is a selective GTPase Cdc42 inhibitor with an EC50 of 2 μM. MLS-573151 is inactive against other GTPases family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2 and RhoA wild-type. MLS-573151 acts by blocking the binding of GTP to Cdc42 .
    MLS-573151
  • HY-RS02300

    Small Interfering RNA (siRNA) Others

    CDC42 Human Pre-designed siRNA Set A contains three designed siRNAs for CDC42 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CDC42 Human Pre-designed siRNA Set A
    CDC42 Human Pre-designed siRNA Set A
  • HY-RS02301

    Small Interfering RNA (siRNA) Others

    CDC42BPA Human Pre-designed siRNA Set A contains three designed siRNAs for CDC42BPA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CDC42BPA Human Pre-designed siRNA Set A
    CDC42BPA Human Pre-designed siRNA Set A
  • HY-RS02302

    Small Interfering RNA (siRNA) Others

    CDC42BPB Human Pre-designed siRNA Set A contains three designed siRNAs for CDC42BPB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CDC42BPB Human Pre-designed siRNA Set A
    CDC42BPB Human Pre-designed siRNA Set A
  • HY-RS02303

    Small Interfering RNA (siRNA) Others

    CDC42EP1 Human Pre-designed siRNA Set A contains three designed siRNAs for CDC42EP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CDC42EP1 Human Pre-designed siRNA Set A
    CDC42EP1 Human Pre-designed siRNA Set A
  • HY-RS02304

    Small Interfering RNA (siRNA) Others

    CDC42EP3 Human Pre-designed siRNA Set A contains three designed siRNAs for CDC42EP3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CDC42EP3 Human Pre-designed siRNA Set A
    CDC42EP3 Human Pre-designed siRNA Set A
  • HY-RS02305

    Small Interfering RNA (siRNA) Others

    CDC42EP4 Human Pre-designed siRNA Set A contains three designed siRNAs for CDC42EP4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CDC42EP4 Human Pre-designed siRNA Set A
    CDC42EP4 Human Pre-designed siRNA Set A
  • HY-112842
    MBQ-167
    5 Publications Verification

    Ras CDK Cancer
    MBQ-167 is a dual Rac/Cdc42 inhibitor, with IC50s of 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively.
    MBQ-167
  • HY-116269

    Ras Apoptosis PAK ERK Cancer
    AZA197 is a selective small molecule inhibitor of Cdc42.AZA197 suppresses colon cancer cell proliferation, cell migration, invasion and increases apoptosis by down-regulating the PAK1 and ERK signaling pathways in vitro. AZA197 reduces tumor growth and significantly increases mouse survival in SW620 tumor xenografts .
    AZA197
  • HY-12755
    ML141
    15+ Cited Publications

    CID-2950007

    Ras Apoptosis Cancer
    ML141 (CID-2950007) is a potent, allosteric, selective and reversible non-competitive inhibitor of Cdc42 GTPase. ML141 inhibits Cdc42 wild type and Cdc42 Q61L mutant with EC50s of 2.1 and 2.6 μM, respectively. ML141 shows low micromolar potency and selectivity against other members of the Rho family of GTPases (Rac1, Rab2, Rab7). ML141 do not show cytotoxicity in multiple cell lines .
    ML141
  • HY-161736

    CDK Cancer
    ARN25499 (compound 15) is a CDC42 inhibitor. ARN25499 can be used in cancer-related research .
    ARN25499
  • HY-12874
    CASIN
    5+ Cited Publications

    Ras Apoptosis Cancer
    CASIN is a selective GTPase Cdc42 inhibitor with an IC50 of 2 uM. CASIN can be used for the research of cancer .
    CASIN
  • HY-111423

    Others Cancer
    BDP8900 is a potent and selective inhibitor of myotonic dystrophy-related Cdc42-binding kinases (MRCKα and MRCKβ). BDP8900 reduces substrate phosphorylation, leading to morphological changes, motility inhibition and invasiveness of cancer cells .
    BDP8900
  • HY-111424A

    Others Cancer
    (R)-BDP9066 is a potent inhibitor of myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK). (R)-BDP9066 blocks cancer cell invasion. (R)-BDP9066 has the potential for the research of proliferative diseases, such as cancer.
    (R)-BDP9066
  • HY-149464

    Ras Cancer
    ARN22089 is a oral active novel class of trisubstituted pyrimidine, blocks the interaction of CDC42 GTPases with specific downstream effectors. ARN22089 blocks tumor growth in BRAF mutant mouse melanoma model .
    ARN22089
  • HY-111424

    Ras Cancer
    BDP9066 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with an IC50 of 64 nM for MRCKβ in SCC12 cells, Ki values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on skin cancer by reducing substrate phosphorylation.
    BDP9066
  • HY-N0710
    alpha-Cyperone
    2 Publications Verification

    α-Cyperone; (+)-α-Cyperone

    Endogenous Metabolite Inflammation/Immunology
    alpha-Cyperone (α-Cyperone) is associated with the down-regulation of COX-2, IL-6, Nck-2, Cdc42 and Rac1, resulting in reduction of inflammation, which would be highly beneficial for treatment of inflammatory diseases such as AD.
    alpha-Cyperone
  • HY-152095

    Ras Cancer
    PPI-GIT1/β-Pix interaction-IN-1 is a potent and orally active GIT1/β-Pix protein-protein interaction (PPI) inhibitor with a KD value of 7.7 µM. PPI-GIT1/β-Pix interaction-IN-1 disrupts the GIT/PIX interaction can impact the activation of the downstream Rho GTPase Rac1 and Cdc42. PPI-GIT1/β-Pix interaction-IN-1 inhibits metastasis of gastric cancer .
    PPI-GIT1/β-Pix interaction-IN-1
  • HY-149921

    Others Cancer
    Antiangiogenic agent 3 (compound 3) is a potent antiangiogenic agent. Antiangiogenic agent 3 is an inhibitor of human umbilical vein endothelial cells (HUVEC). Antiangiogenic agent 3 inhibits HUVEC migration and chemotactic motilities. Antiangiogenic agent 3 also decreases the gene expression of Src, cdc42, and MAPK .
    Antiangiogenic agent 3
  • HY-N0710R

    Endogenous Metabolite Inflammation/Immunology
    alpha-Cyperone (Standard) is the analytical standard of alpha-Cyperone. This product is intended for research and analytical applications. alpha-Cyperone (α-Cyperone) is associated with the down-regulation of COX-2, IL-6, Nck-2, Cdc42 and Rac1, resulting in reduction of inflammation, which would be highly beneficial for treatment of inflammatory diseases such as AD.
    alpha-Cyperone (Standard)
  • HY-12646
    Rhosin hydrochloride
    Maximum Cited Publications
    24 Publications Verification

    Ras Apoptosis Cancer
    Rhosin hydrochloride is a potent, specific RhoA subfamily Rho GTPases inhibitor. Rhosin hydrochloride specifically binds to RhoA to inhibit RhoA-GEF interaction with a Kd of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin hydrochloride induces cell apoptosis . Rhosin hydrochloride promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability .
    Rhosin hydrochloride
  • HY-12646A

    Ras Apoptosis Cancer
    Rhosin is a potent, specific RhoA subfamily Rho GTPases inhibitor, which specifically binds to RhoA to inhibit RhoA-GEF interaction with a Kd of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin induces cell apoptosis . Rhosin promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability .
    Rhosin
  • HY-I0400
    N-Acetylneuraminic acid
    3 Publications Verification

    NANA; Lactaminic acid

    Tyrosinase Ras Influenza Virus Endogenous Metabolite Cardiovascular Disease Inflammation/Immunology Cancer
    N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia .
    N-Acetylneuraminic acid
  • HY-10943
    GNF-7
    2 Publications Verification

    Bcr-Abl Ack1 Cancer
    GNF-7 is a multikinase inhibitor. GNF-7 is a Bcr-Abl inhibitor, with IC50s of 133 nM and 61 nM for Bcr-Abl WT and Bcr-Abl T315I, respectively. GNF-7 also possesses inhibitory activity against both ACK1 (activated CDC42 kinase 1) and GCK (germinal center kinase) with IC50s of 25 nM and 8 nM, respectively. GNF-7 can be used for the research of hematologic malignancies .
    GNF-7
  • HY-115376

    ZINC08010136

    Ras Inflammation/Immunology
    Z62954982 (ZINC08010136) is a potent, selective and?cell-permeable Rac1 (IC50=12 μM) inhibitor that is 4 times more effective than NSC23766 (HY-15723A) (IC50=50 μM). Z62954982?disrupts the Rac1/Tiam1 complex and decreases cytoplasmic levels of active Rac1 (GTP-bound Rac1), without affecting the activity of other Rho GTPases (such as Cdc42 or RhoA) .
    Z62954982
  • HY-12810
    EHop-016
    4 Publications Verification

    Ras Cancer
    EHop-016 is a potent and selective Rac GTPase Rac1 and Rac3 inhibitor. EHop-016 inhibits Rac1 activity with an IC50 of 1.1 μM in MDA-MB-435 cells. EHop-016 inhibits Vav2 interaction with Rac, Rac-activated PAK1, lamellipodia formation, and cell migration .
    EHop-016

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